AAH06545.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,907 Da
NCBI Official Full Name
FOXA2 protein, partial
NCBI Official Synonym Full Names
forkhead box A2
NCBI Official Synonym Symbols
NCBI Protein Information
hepatocyte nuclear factor 3-beta
UniProt Protein Name
Hepatocyte nuclear factor 3-beta
UniProt Synonym Protein Names
Forkhead box protein A2; Transcription factor 3B; TCF-3B
UniProt Synonym Gene Names
UniProt Entry Name
FOXA2_HUMAN
NCBI Summary for FOXA2
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for FOXA2
FOXA2: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. Binds DNA as a monomer. Binds TLE1. Interacts with FOXA1 and FOXA3. Interacts with PRKDC. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 20p11
Cellular Component: cell junction; cytoplasm; nucleoplasm; nucleus
Molecular Function: DNA binding; protein domain specific binding; transcription factor activity; transcription factor binding
Biological Process: adult locomotory behavior; cell fate specification; chromatin modification; endocrine pancreas development; negative regulation of glucokinase activity; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter by glucose; positive regulation of embryonic development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by glucose; positive regulation of transcription, DNA-dependent; regulation of blood coagulation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
Research Articles on FOXA2
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Products associated with anti-FOXA2 antibody
Pathways associated with anti-FOXA2 antibody
Diseases associated with anti-FOXA2 antibody
Organs/Tissues associated with anti-FOXA2 antibody
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