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anti-FOXA3 antibody :: Rabbit FOXA3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS462181
Testing Data
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOXA3, Polyclonal Antibody

 Also Known As   

Rabbit anti FOXA3/HNF3G Polyclonal antibody

 Product Synonym Names    Rabbit anti-FOXA3; Forkhead Box A2 (FOXA3); Hepatocyte nuclear factor 3 gamma (HNF3G)
 Product Gene Name   

anti-FOXA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (46367518..46377055). Location: 19q13.2-q13.4
 OMIM    602295
 3D Structure    ModBase 3D Structure for P55318
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody recognizes ~37 kDa of FOXA3 protein. It also reacts with human, mouse and rat. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Epitope Affinity qPurification.
 Form/Format    This affinity purified antibody is supplied in sterile phosphatebuffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide corresponding to the C-terminus of human FOXA3 protein. This sequence is identical to rat, mouse and human origins.
 Positive Control    Huh 7 cells
 Cellular Location    Nuclear
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-FOXA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FOXA3 antibody

   The forkhead box gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA1 plays an important role in breast cancer. The FOXA subfamily is composed of the transcription factors FOXA1, A2, A3. They were discovered as the regulators of hepatic genes. Foxa1 has been shown to be required for glucagon secretion in the pancreas, whereas Foxa2 is critical for the regulation of insulin secretion in pancreatic beta-cells. Foxa3 is important in the maintenance of glucose homeostasis, it is the dominating transcriptional regulator of GLUT2 expression in hepatocytes in vivo. In the normal activation of HNF-4alpha, HNF-1alpha, and PGC-1 induced by fasting is attenuated in mice lacking Foxa3.
 Applications Tested/Suitable for anti-FOXA3 antibody   

ELISA, Western Blot

 Application Notes for anti-FOXA3 antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
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 Testing Data of anti-FOXA3 antibody    anti-FOXA3 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for FOXA3. It may not necessarily be applicable to this product.
 NCBI GI #    160431602
 NCBI GeneID    3171
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 UniProt Primary Accession #    P55318 [Other Products]
 UniProt Secondary Accession #    Q53F16; Q9UMW9; A9LYI5 [Other Products]
 UniProt Related Accession #    P55318 [Other Products]
 Molecular Weight    ~37 kDa
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 NCBI Official Full Name    forkhead box A3
 NCBI Official Synonym Full Names    forkhead box A3
 NCBI Official Symbol    FOXA3 [Similar Products]
 NCBI Official Synonym Symbols   
FKHH3; HNF3G; TCF3G; MGC10179
[Similar Products]
 NCBI Protein Information    hepatocyte nuclear factor 3-gamma; HNF-3G; TCF-3G; HNF-3-gamma; forkhead box protein A3; transcription factor 3G; fork head-related protein FKH H3; hepatocyte nuclear factor 3, gamma
 UniProt Protein Name    Hepatocyte nuclear factor 3-gamma
 UniProt Synonym Protein Names   
Fork head-related protein FKH H3; Forkhead box protein A3; Transcription factor 3G
 Protein Family    Hepatocyte nuclear factor
 UniProt Gene Name    FOXA3 [Similar Products]
 UniProt Synonym Gene Names    HNF3G; TCF3G [Similar Products]
 UniProt Entry Name    FOXA3_HUMAN
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 NCBI Summary for FOXA3    This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq]
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 UniProt Comments for FOXA3    Function: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites

By similarity. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Ref.9

Subunit structure: Interacts with FOXA2. Ref.10

Subcellular location: Nucleus Ref.11.

Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined. Ref.1

Developmental stage: Detected in prenatal liver nuclear extracts (12.4-27 weeks estimated gestational age). Not detected in postnatal liver samples. Ref.11

Sequence similarities: Contains 1 fork-head DNA-binding domain.
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Product References and Citations for anti-FOXA3 antibody

   Shen W et al. Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. 2001 Nov 16;276 (46):42812-7.
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 Research Articles on FOXA3    1. analysis of the binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FOXA3 antibodyDiseases associated with anti-FOXA3 antibody
 Products by Pathway  Pathway Diagram
 FOXA Transcription Factor Networks Pathway antibodies  FOXA Transcription Factor Networks Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Regulation Of Beta-cell Development Pathway antibodies  Regulation Of Beta-cell Development Pathway Diagram
 Regulation Of Gene Expression In Beta Cells Pathway antibodies  Regulation Of Gene Expression In Beta Cells Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with FOXA3 and Neoplasms
 Liver Diseases Antibodies  >15 publications with FOXA3 and Liver Diseases
 Liver Neoplasms Antibodies  >12 publications with FOXA3 and Liver Neoplasms
 Carcinoma Antibodies  >7 publications with FOXA3 and Carcinoma
 Carcinoma, Hepatocellular Antibodies  >6 publications with FOXA3 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >6 publications with FOXA3 and Adenocarcinoma
 Inflammation Antibodies  >5 publications with FOXA3 and Inflammation
 Liver Neoplasms, Experimental Antibodies  >5 publications with FOXA3 and Liver Neoplasms, Experimental
 Precancerous Conditions Antibodies  >3 publications with FOXA3 and Precancerous Conditions
 Lung Diseases Antibodies  >3 publications with FOXA3 and Lung Diseases
Organs/Tissues associated with anti-FOXA3 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >60 publications with FOXA3 and Liver
 Embryonic Tissue Antibodies  >14 publications with FOXA3 and Embryonic Tissue
 Intestine Antibodies  >10 publications with FOXA3 and Intestine
 Pancreas Antibodies  >9 publications with FOXA3 and Pancreas
 Stomach Antibodies  >6 publications with FOXA3 and Stomach
 Bone Antibodies  >5 publications with FOXA3 and Bone
 Prostate Antibodies  >2 publications with FOXA3 and Prostate
 Connective Tissue Antibodies  >1 publications with FOXA3 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with FOXA3 and Uncharacterized Tissue
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