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anti-FOXC1 antibody :: Rabbit FOXC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617460 anti-FOXC1 antibody
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.1 mg  /  $480 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOXC1, Polyclonal Antibody

 Also Known As   

FOXC1 (Forkhead Box C1, Forkhead-Related Protein FKHL7, Forkhead-Related Transcription Factor 3, FREAC3)

 Product Synonym Names    Anti -FOXC1 (Forkhead Box C1, Forkhead-Related Protein FKHL7, Forkhead-Related Transcription Factor 3, FREAC3)
 Product Gene Name   

anti-FOXC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (1610681..1614132). Location: 6p25
 OMIM    601090
 3D Structure    ModBase 3D Structure for Q12948
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rodent
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 Specificity    Recognizes human FOXC1. Species Crossreactivity: rodent.
 Purity/Purification    Affinity Purified
Purified by affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, sodium azide, 40% glycerol.
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 Immunogen    Synthetic peptide, aa460-474 GHHPAAHQGRLTSWY of human FOXC1 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-FOXC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-FOXC1 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-FOXC1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-FOXC1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA (serum titer): 1:125,000.
Western Blot:
Human brain 105, 118kD
Human liver 51kD
HepG2 90, 118kD
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NCBI/Uniprot data below describe general gene information for FOXC1. It may not necessarily be applicable to this product.
 NCBI GI #    119395716
 NCBI GeneID    2296
 NCBI Accession #    NP_001444.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001453.2 [Other Products]
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 UniProt Primary Accession #    Q12948 [Other Products]
 UniProt Secondary Accession #    Q86UP7; Q9BYM1; Q9NUE5; Q9UDD0; Q9UP06 [Other Products]
 UniProt Related Accession #    Q12948 [Other Products]
 Molecular Weight    56.79kD. [Similar Products]
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 NCBI Official Full Name    forkhead box protein C1
 NCBI Official Synonym Full Names    forkhead box C1
 NCBI Official Symbol    FOXC1 [Similar Products]
 NCBI Official Synonym Symbols   
ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3
[Similar Products]
 NCBI Protein Information    forkhead box protein C1; OTTHUMP00000017802; myeloid factor-delta; forkhead-related activator 3; forkhead-related protein FKHL7; forkhead, drosophila, homolog-like 7; forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7
 UniProt Protein Name    Forkhead box protein C1
 UniProt Synonym Protein Names   
Forkhead-related protein FKHL7; Forkhead-related transcription factor 3
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXC1 [Similar Products]
 UniProt Synonym Gene Names    FKHL7; FREAC3 [Similar Products]
 UniProt Entry Name    FOXC1_HUMAN
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 NCBI Summary for FOXC1    This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq]
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 UniProt Comments for FOXC1    FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined.

Protein type: Cell cycle regulation; Transcription factor; DNA-binding; Cell development/differentiation

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: nucleoplasm; cytoplasm; nuclear heterochromatin; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding; DNA bending activity

Biological Process: transcription from RNA polymerase II promoter; collagen fibril organization; glycosaminoglycan metabolic process; neural crest cell development; paraxial mesoderm formation; positive regulation of transcription, DNA-dependent; heart development; cardiac muscle cell proliferation; regulation of transcription, DNA-dependent; ovarian follicle development; ureteric bud development; germ cell migration; ventricular cardiac muscle morphogenesis; negative regulation of mitotic cell cycle; lacrimal gland development; regulation of blood vessel size; skeletal development; mesenchymal cell development; somitogenesis; cell migration; ossification; Notch signaling pathway; camera-type eye development; in utero embryonic development; regulation of organ growth; odontogenesis of dentine-containing teeth; cell proliferation; eye development; artery morphogenesis; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; brain development; vascular endothelial growth factor receptor signaling pathway; lymph vessel development

Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1
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 Research Articles on FOXC1    1. FOXC1 and PITX2 genetic defects explain 40% of our large anterior segment malformations.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FOXC1 antibodyDiseases associated with anti-FOXC1 antibody
 Products by Pathway  Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >81 publications with FOXC1 and Congenital Abnormalities
 Eye Abnormalities Antibodies  >76 publications with FOXC1 and Eye Abnormalities
 Neoplasms Antibodies  >13 publications with FOXC1 and Neoplasms
 Craniofacial Abnormalities Antibodies  >10 publications with FOXC1 and Craniofacial Abnormalities
 Hearing Loss Antibodies  >9 publications with FOXC1 and Hearing Loss
 Skin Diseases Antibodies  >8 publications with FOXC1 and Skin Diseases
 Breast Neoplasms Antibodies  >6 publications with FOXC1 and Breast Neoplasms
 Carcinoma Antibodies  >5 publications with FOXC1 and Carcinoma
 Heart Defects, Congenital Antibodies  >5 publications with FOXC1 and Heart Defects, Congenital
 Nervous System Malformations Antibodies  >4 publications with FOXC1 and Nervous System Malformations
Organs/Tissues associated with anti-FOXC1 antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >106 publications with FOXC1 and Eye
 Embryonic Tissue Antibodies  >20 publications with FOXC1 and Embryonic Tissue
 Bone Antibodies  >14 publications with FOXC1 and Bone
 Heart Antibodies  >11 publications with FOXC1 and Heart
 Kidney Antibodies  >10 publications with FOXC1 and Kidney
 Vascular Antibodies  >10 publications with FOXC1 and Vascular
 Brain Antibodies  >8 publications with FOXC1 and Brain
 Nerve Antibodies  >8 publications with FOXC1 and Nerve
 Prostate Antibodies  >4 publications with FOXC1 and Prostate
 Skin Antibodies  >3 publications with FOXC1 and Skin
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