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anti-FOXG1 antibody :: Rabbit FOXG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205338
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOXG1, Polyclonal Antibody

★Popular Item★
 Also Known As   

FOXG1 Antibody (Center)

 Product Synonym Names    Forkhead box protein G1; Brain factor 1; BF-1; BF1; Brain factor 2; BF-2; BF2; hBF-2; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; Forkhead-related protein FKHL1; HFK1; Forkhead-related protein FKHL2; HFK2; Forkhead-related protein FKHL3; HFK3; FOXG1
 Product Gene Name   

anti-FOXG1 antibody

[Similar Products]
 Antibody/Peptide Pairs    FOXG1 peptide (MBS9228407) is used for blocking the activity of FOXG1 antibody (MBS9205338)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    225-252
 OMIM    164874
 3D Structure    ModBase 3D Structure for P55316
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse (Predicted Reactivity: Chicken, Rat, Xenopus, Drosophila)
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 Specificity    This FOXG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-252 amino acids from the Central region of human FOXG1.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-FOXG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FOXG1 antibody

   This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of the brain and telencephalon.
 Product Categories/Family for anti-FOXG1 antibody    Neuroscience
 Applications Tested/Suitable for anti-FOXG1 antibody   

Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-FOXG1 antibody    WB~~1:1000
FC~~1:10~50
IF~~1:10~50
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 Test Data of anti-FOXG1 antibody    Anti-FOXG1 Antibody (Center) at 1:1000 dilution + human brain lysate Lysates/proteins at 20 ?g per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 52 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
anti-FOXG1 antibody Test Data image
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 Western Blot (WB) of anti-FOXG1 antibody    Western blot analysis of FOXG1 Antibody (Center) in mouse brain tissue lysates (35ug/lane). FOXG1 (arrow) was detected using the purified Pab.
anti-FOXG1 antibody Western Blot (WB) (WB) image
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 Flow Cytometry (FC/FACS) of anti-FOXG1 antibody    FOXG1 Antibody (Center) flow cytometric analysis of U251 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-FOXG1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunofluorescence (IF) of anti-FOXG1 antibody    Fluorescent confocal image of A549 cell stained with FOXG1 Antibody (Center). A549 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with FOXG1 primary antibody (1:25, 1 h at 37 degree). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). FOXG1 immunoreactivity is localized to Nucleus significantly.
anti-FOXG1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for FOXG1. It may not necessarily be applicable to this product.
 NCBI GI #    32307177
 NCBI GeneID    2290
 NCBI Accession #    NP_005240.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005249.4 [Other Products]
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 UniProt Primary Accession #    P55316 [Other Products]
 UniProt Secondary Accession #    P55315; Q14488; Q86XT7; A6NFY2 [Other Products]
 UniProt Related Accession #    P55316 [Other Products]
 Molecular Weight    52352
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 NCBI Official Full Name    forkhead box protein G1
 NCBI Official Synonym Full Names    forkhead box G1
 NCBI Official Symbol    FOXG1 [Similar Products]
 NCBI Official Synonym Symbols   
BF1; BF2; QIN; FKH2; HBF2; HFK1; HFK2; HFK3; KHL2; FHKL3; FKHL1; FKHL2; FKHL3; FKHL4; HBF-1; HBF-2; HBF-3; FOXG1A; FOXG1B; FOXG1C; HBF-G2
[Similar Products]
 NCBI Protein Information    forkhead box protein G1
 UniProt Protein Name    Forkhead box protein G1
 UniProt Synonym Protein Names   
Brain factor 1; BF-1; BF1; Brain factor 2; BF-2; BF2; hBF-2; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; Forkhead-related protein FKHL1; HFK1; Forkhead-related protein FKHL2; HFK2; Forkhead-related protein FKHL3; HFK3
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXG1 [Similar Products]
 UniProt Synonym Gene Names    FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; BF-1; BF1; BF-2; BF2; hBF-2; HFK1; HFK2; HFK3 [Similar Products]
 UniProt Entry Name    FOXG1_HUMAN
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 NCBI Summary for FOXG1    This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]
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 UniProt Comments for FOXG1    FOXG1: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Interacts with KDM5B. Expression is restricted to the neurons of the developing telencephalon.

Protein type: Nuclear receptor co-regulator; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription, DNA-dependent; brain development; negative regulation of transcription, DNA-dependent; aging

Disease: Rett Syndrome, Congenital Variant
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Product References and Citations for anti-FOXG1 antibody

   Mencarelli, M.A., et al. J. Med. Genet. 47(1):49-53(2010)
Philippe, C., et al. J. Med. Genet. 47(1):59-65(2010)
Ariani, F., et al. Am. J. Hum. Genet. 83(1):89-93(2008)
Adesina, A.M., et al. J. Neurooncol. 85(2):111-122(2007)
Bredenkamp, N., et al. Dev. Genes Evol. 217(3):227-233(2007)
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 Research Articles on FOXG1    1. critical role in the regulation of hepatocellular carcinoma development
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FOXG1 antibodyPathways associated with anti-FOXG1 antibody
 Reference Product  PubMed Publications
 FOXO1 antibody  >7 publications with FOXG1 and FOXO1
 TLE1 antibody  >3 publications with FOXG1 and TLE1
 FOXO3 antibody  >2 publications with FOXG1 and FOXO3
 AKT1 antibody  >1 publications with FOXG1 and AKT1
 SMAD3 antibody  >1 publications with FOXG1 and SMAD3
 FOXO4 antibody  >1 publications with FOXG1 and FOXO4
 SMAD2 antibody  >1 publications with FOXG1 and SMAD2
 SMAD4 antibody  >1 publications with FOXG1 and SMAD4
 KDM5B antibody  >1 publications with FOXG1 and KDM5B
 Products by Pathway  Pathway Diagram
 Two-component System Pathway antibodies  Two-component System Pathway Diagram
 Two-component System Pathway antibodies  Two-component System Pathway Diagram
 Two-component System Pathway antibodies  Two-component System Pathway Diagram
Diseases associated with anti-FOXG1 antibodyOrgans/Tissues associated with anti-FOXG1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >80 publications with FOXG1 and Nervous System Diseases
 Intellectual Disability Antibodies  >53 publications with FOXG1 and Intellectual Disability
 Neurobehavioral Manifestations Antibodies  >50 publications with FOXG1 and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >31 publications with FOXG1 and Congenital Abnormalities
 Microcephaly Antibodies  >27 publications with FOXG1 and Microcephaly
 RETT SYNDROME, CONGENITAL VARIANT Antibodies  >23 publications with FOXG1 and RETT SYNDROME, CONGENITAL VARIANT
 Craniofacial Abnormalities Antibodies  >19 publications with FOXG1 and Craniofacial Abnormalities
 Nervous System Malformations Antibodies  >18 publications with FOXG1 and Nervous System Malformations
 Seizures Antibodies  >14 publications with FOXG1 and Seizures
 Disease Models, Animal Antibodies  >12 publications with FOXG1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >149 publications with FOXG1 and Brain
 Testis Antibodies  >4 publications with FOXG1 and Testis
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