NP_036320.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,814 Da
NCBI Official Full Name
forkhead box protein I1 isoform a
NCBI Official Synonym Full Names
forkhead box I1
NCBI Official Synonym Symbols
HFH3; FKH10; HFH-3; FKHL10; FREAC6; FREAC-6 [Similar Products]
NCBI Protein Information
forkhead box protein I1
UniProt Protein Name
Forkhead box protein I1
UniProt Synonym Protein Names
Forkhead-related protein FKHL10; Forkhead-related transcription factor 6; FREAC-6; Hepatocyte nuclear factor 3 forkhead homolog 3; HFH-3; HNF-3/fork-head homolog 3
UniProt Synonym Gene Names
NCBI Summary for FOXI1
This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017]
UniProt Comments for FOXI1
FOXI1: Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5q35.1
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: positive regulation of transcription from RNA polymerase II promoter
Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome
Research Articles on FOXI1
Precautions
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Products associated with anti-FOXI1 antibody
Diseases associated with anti-FOXI1 antibody
Disease Name |
Pubmed Publications |
Nervous System Diseases Antibodies |
>15 publications with FOXI1 and Nervous System Diseases |
DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT Antibodies |
>10 publications with FOXI1 and DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT |
Liver Neoplasms Antibodies |
>2 publications with FOXI1 and Liver Neoplasms |
Craniofacial Abnormalities Antibodies |
>2 publications with FOXI1 and Craniofacial Abnormalities |
Heart Diseases Antibodies |
>1 publications with FOXI1 and Heart Diseases |
Liver Neoplasms, Experimental Antibodies |
>1 publications with FOXI1 and Liver Neoplasms, Experimental |
Adenocarcinoma Antibodies |
>1 publications with FOXI1 and Adenocarcinoma |
Fetal Death Antibodies |
>1 publications with FOXI1 and Fetal Death |
Infertility, Female Antibodies |
>1 publications with FOXI1 and Infertility, Female |
Infertility, Male Antibodies |
>1 publications with FOXI1 and Infertility, Male |
Organs/Tissues associated with anti-FOXI1 antibody
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