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anti-FOXP2 antibody :: Goat FOXP2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421233
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FOXP2, Polyclonal Antibody

 Also Known As   

Goat anti-FOXP2 (C terminus) Antibody

 Product Synonym Names    Goat Anti-FOXP2 (internal) Antibody; FOXP2; forkhead box P2; SPCH1; CAGH44; TNRC10; CAG repeat protein 44; speech and language disorder 1; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; DKFZp686H1726; OTTHUMP00000196932; FOXP2 antibody; forkhead box P2 antibody; SPCH1 antibody; CAGH44 antibody; TNRC10 antibody; CAG repeat protein 44 antibody; speech and language disorder 1 antibody; trinucleotide repeat containing 10 antibody; forkhead/winged-helix transcription factor antibody; DKFZp686H1726 antibody; OTTHUMP00000196932 antibody; FOXP2 (C terminus)
 Product Gene Name   

anti-FOXP2 antibody

[Similar Products]
 Antibody/Peptide Pairs    FOXP2 peptide (MBS428462) is used for blocking the activity of FOXP2 antibody (MBS421233)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    REIEEEPLSE DLE
 OMIM    602081
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow etc
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-REIEEEPLSEDLE, from the C Terminus of the protein sequence according to NP_055306.1; NP_683696.2; NP_683697.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise all three reported isoforms (NP_055306.1; NP_683696.2; NP_683697.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-FOXP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FOXP2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-FOXP2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: An anonymous customer found positive results in IHC on Mouse embryonic spinal cord.
Western Blot: Approx 80kDa band observed in human brain (cerebellum) lysates (calculated MW of 79.9kDa according to NP_055306.1). Recommended concentration: 0.5-1.5ug/ml.
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 Western Blot (WB) of anti-FOXP2 antibody    (0.5ug/ml) staining of human cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-FOXP2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FOXP2. It may not necessarily be applicable to this product.
 NCBI GI #    17017963
 NCBI GeneID    93986
 NCBI Accession #    NP_055306.1 [Other Products]
 NCBI Related Accession #    NP_683696.2; NP_683697.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_014491.3 [Other Products]
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 UniProt Secondary Accession #    Q6ZND1; Q75MJ3; Q8IZE0; Q8N0W2; Q8N6B7; Q8N6B8; Q8NFQ1; A0AUV6; A4D0U8; A6NNW4; B4DLD9 [Other Products]
 UniProt Related Accession #    O15409 [Other Products]
 Molecular Weight    81,840 Da
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 NCBI Official Full Name    forkhead box protein P2 isoform I
 NCBI Official Synonym Full Names    forkhead box P2
 NCBI Official Symbol    FOXP2 [Similar Products]
 NCBI Official Synonym Symbols   
SPCH1; CAGH44; TNRC10
[Similar Products]
 NCBI Protein Information    forkhead box protein P2
 UniProt Protein Name    Forkhead box protein P2
 UniProt Synonym Protein Names   
CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
 Protein Family    Forkhead box protein
 UniProt Gene Name    FOXP2 [Similar Products]
 UniProt Synonym Gene Names    CAGH44; TNRC10 [Similar Products]
 UniProt Entry Name    FOXP2_HUMAN
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 NCBI Summary for FOXP2    This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
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 UniProt Comments for FOXP2    FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: alveolus development; camera-type eye development; caudate nucleus development; cerebellum development; cerebral cortex development; growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of mesenchymal cell proliferation; post-embryonic development; putamen development; righting reflex; skeletal muscle development; smooth muscle development; transcription, DNA-dependent; vocal learning

Disease: Speech-language Disorder 1
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 Research Articles on FOXP2    1. Our results suggested that FOXP2 expression was downregulated in Hepatocellular carcinoma tumor tissues, and reduced FOXP2 expression was associated with poor overall survival
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FOXP2 antibodyDiseases associated with anti-FOXP2 antibody
 Reference Product  PubMed Publications
 FOXP1 antibody  >65 publications with FOXP2 and FOXP1
 FOXP4 antibody  >16 publications with FOXP2 and FOXP4
 NKX2-1 antibody  >9 publications with FOXP2 and NKX2-1
 DISC1 antibody  >5 publications with FOXP2 and DISC1
 CDH2 antibody  >1 publications with FOXP2 and CDH2
 LEF1 antibody  >1 publications with FOXP2 and LEF1
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >122 publications with FOXP2 and Nervous System Diseases
 Neurobehavioral Manifestations Antibodies  >111 publications with FOXP2 and Neurobehavioral Manifestations
 Learning Disorders Antibodies  >38 publications with FOXP2 and Learning Disorders
 Cognition Disorders Antibodies  >30 publications with FOXP2 and Cognition Disorders
 Brain Diseases Antibodies  >24 publications with FOXP2 and Brain Diseases
 Autistic Disorder Antibodies  >23 publications with FOXP2 and Autistic Disorder
 Disease Models, Animal Antibodies  >15 publications with FOXP2 and Disease Models, Animal
 SPEECH-LANGUAGE DISORDER 1 Antibodies  >15 publications with FOXP2 and SPEECH-LANGUAGE DISORDER 1
 Apraxias Antibodies  >15 publications with FOXP2 and Apraxias
 Nervous System Malformations Antibodies  >5 publications with FOXP2 and Nervous System Malformations
Organs/Tissues associated with anti-FOXP2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >217 publications with FOXP2 and Brain
 Nerve Antibodies  >51 publications with FOXP2 and Nerve
 Lung Antibodies  >19 publications with FOXP2 and Lung
 Embryonic Tissue Antibodies  >18 publications with FOXP2 and Embryonic Tissue
 Bone Antibodies  >9 publications with FOXP2 and Bone
 Eye Antibodies  >8 publications with FOXP2 and Eye
 Muscle Antibodies  >7 publications with FOXP2 and Muscle
 Thyroid Antibodies  >6 publications with FOXP2 and Thyroid
 Skin Antibodies  >5 publications with FOXP2 and Skin
 Kidney Antibodies  >5 publications with FOXP2 and Kidney
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