NP_001180235.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
fMet-Leu-Phe receptor
NCBI Official Synonym Full Names
formyl peptide receptor 1
NCBI Official Synonym Symbols
NCBI Protein Information
fMet-Leu-Phe receptor
UniProt Protein Name
fMet-Leu-Phe receptor
UniProt Synonym Protein Names
N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor
UniProt Synonym Gene Names
UniProt Entry Name
FPR1_HUMAN
NCBI Summary for FPR1
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
UniProt Comments for FPR1
FPR1: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: endosome; integral to membrane; plasma membrane
Molecular Function: N-formyl peptide receptor activity; protein binding; RAGE receptor binding; receptor activity
Biological Process: activation of MAPK activity; cell motility; chemotaxis; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); nitric oxide mediated signal transduction; signal transduction
Research Articles on FPR1
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Products associated with anti-FPR1 antibody
Pathways associated with anti-FPR1 antibody
Diseases associated with anti-FPR1 antibody
Organs/Tissues associated with anti-FPR1 antibody
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