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anti-MTOR antibody :: Rabbit anti-Human FRAP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS630738 anti-MTOR antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FRAP1 (MTOR), Polyclonal Antibody

 Also Known As   

FRAP1 (S2481) (Serine/Threonine-protein Kinase mTOR, Mechanistic Target Of Rapamycin, FK506-binding Protein 12-rapamycin Complex-associated Protein 1, FKBP12-rapamycin Complex-associated Protein, Rapamycin Target Protein 1, RAPT1, Mammalian Target Of Rapa

 Product Synonym Names    Anti -FRAP1 (S2481) (Serine/Threonine-protein Kinase mTOR, Mechanistic Target Of Rapamycin, FK506-binding Protein 12-rapamycin Complex-associated Protein 1, FKBP12-rapamycin Complex-associated Protein, Rapamycin Target Protein 1, RAPT1, Mammalian Target Of Rapa
 Product Gene Name   

anti-MTOR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (11166588..11322614, complement). Location: 1p36.2
 OMIM    601231
 3D Structure    ModBase 3D Structure for P42345
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human FRAP1.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic non-phosphopeptide corresponding to amino acid residues surrounding S2481 of human FRAP1 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-MTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MTOR antibody

   FRAP1 belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. FRAP1 is a part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.
 Product Categories/Family for anti-MTOR antibody    Antibodies; Abs to Binding Proteins
 Applications Tested/Suitable for anti-MTOR antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-MTOR antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
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NCBI/Uniprot data below describe general gene information for MTOR. It may not necessarily be applicable to this product.
 NCBI GI #    119592089
 NCBI GeneID    2475
 NCBI Accession #    EAW71683.1 [Other Products]
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 UniProt Primary Accession #    P42345 [Other Products]
 UniProt Secondary Accession #    Q4LE76; Q5TER1; Q6LE87; Q96QG3; Q9Y4I3 [Other Products]
 UniProt Related Accession #    P42345 [Other Products]
 Molecular Weight    288,892 Da [Similar Products]
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 NCBI Official Full Name    FK506 binding protein 12-rapamycin associated protein 1, isoform CRA_c
 NCBI Official Synonym Full Names    mechanistic target of rapamycin (serine/threonine kinase)
 NCBI Official Symbol    MTOR [Similar Products]
 NCBI Official Synonym Symbols   
FRAP; FRAP1; FRAP2; RAFT1; RAPT1
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase mTOR; rapamycin target protein 1; mammalian target of rapamycin; rapamycin and FKBP12 target 1; FKBP-rapamycin associated protein; rapamycin associated protein FRAP2; FKBP12-rapamycin complex-associated protein 1; FK506 binding protein 12-rapamycin associated protein 2; FK506-binding protein 12-rapamycin complex-associated protein 1
 UniProt Protein Name    Serine/threonine-protein kinase mTOR
 UniProt Synonym Protein Names   
FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    MTOR [Similar Products]
 UniProt Synonym Gene Names    FRAP; FRAP1; FRAP2; RAFT1; RAPT1; mTOR [Similar Products]
 UniProt Entry Name    MTOR_HUMAN
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 NCBI Summary for MTOR    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for MTOR    mTOR: an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779).

Protein type: EC 2.7.11.1; Protein kinase, atypical; Protein kinase, Ser/Thr (non-receptor); Autophagy; Motility/polarity/chemotaxis; Kinase, protein; ATYPICAL group; PIKK family; FRAP subfamily

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: endoplasmic reticulum membrane; PML body; lysosome; lysosomal membrane; dendrite; endomembrane system; cytosol; Golgi membrane; nucleoplasm; mitochondrial outer membrane; membrane; cell soma; cytoplasm; TORC2 complex; phosphoinositide 3-kinase complex; nucleus

Molecular Function: protein dimerization activity; protein domain specific binding; protein serine/threonine kinase activity; protein binding; phosphoprotein binding; ribosome binding; drug binding; kinase activity; ATP binding

Biological Process: negative regulation of autophagy; TOR signaling pathway; regulation of myelination; positive regulation of translation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; regulation of glycogen biosynthetic process; negative regulation of cell size; signal transduction; protein amino acid phosphorylation; germ cell development; negative regulation of macroautophagy; cellular response to nutrient levels; positive regulation of stress fiber formation; regulation of carbohydrate utilization; response to stress; protein catabolic process; cell growth; response to nutrient; regulation of response to food; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; peptidyl-threonine phosphorylation; positive regulation of lipid biosynthetic process; negative regulation of NFAT protein import into nucleus; response to amino acid stimulus; double-strand break repair via homologous recombination; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; ruffle organization and biogenesis; insulin receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase III promoter; regulation of fatty acid beta-oxidation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; regulation of protein kinase activity; phosphorylation; growth
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 Research Articles on MTOR    1. ULK1-dependent autophagy degrades BNIP3 via MTORC1 and AMPK
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MTOR antibodyPathways associated with anti-MTOR antibody
 Reference Product  PubMed Publications
 EIF4EBP1 antibody  >455 publications with MTOR and EIF4EBP1
 AKT1 antibody  >366 publications with MTOR and AKT1
 RICTOR antibody  >269 publications with MTOR and RICTOR
 RHEB antibody  >241 publications with MTOR and RHEB
 STAT3 antibody  >174 publications with MTOR and STAT3
 RPTOR antibody  >146 publications with MTOR and RPTOR
 MLST8 antibody  >43 publications with MTOR and MLST8
 RPS6KB1 antibody  >23 publications with MTOR and RPS6KB1
 MAPKAP1 antibody  >16 publications with MTOR and MAPKAP1
 FKBP1A antibody  >5 publications with MTOR and FKBP1A
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
Diseases associated with anti-MTOR antibodyOrgans/Tissues associated with anti-MTOR antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4624 publications with MTOR and Neoplasms
 Nervous System Diseases Antibodies  >831 publications with MTOR and Nervous System Diseases
 Adenocarcinoma Antibodies  >830 publications with MTOR and Adenocarcinoma
 Kidney Diseases Antibodies  >678 publications with MTOR and Kidney Diseases
 Breast Neoplasms Antibodies  >560 publications with MTOR and Breast Neoplasms
 Carcinoma, Renal Cell Antibodies  >516 publications with MTOR and Carcinoma, Renal Cell
 Cardiovascular Diseases Antibodies  >456 publications with MTOR and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >400 publications with MTOR and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >387 publications with MTOR and Lung Neoplasms
 Hypertrophy Antibodies  >356 publications with MTOR and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1372 publications with MTOR and Blood
 Muscle Antibodies  >1129 publications with MTOR and Muscle
 Kidney Antibodies  >1109 publications with MTOR and Kidney
 Vascular Antibodies  >1013 publications with MTOR and Vascular
 Brain Antibodies  >975 publications with MTOR and Brain
 Liver Antibodies  >764 publications with MTOR and Liver
 Lung Antibodies  >654 publications with MTOR and Lung
 Heart Antibodies  >463 publications with MTOR and Heart
 Bone Antibodies  >353 publications with MTOR and Bone
 Prostate Antibodies  >336 publications with MTOR and Prostate
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