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Add To Compare List anti-FRS2 antibody :: Rabbit anti-Human, Mouse FRS2 Polyclonal Antibody Catalog # MBS9601235 Unit / Price 0.1 mL / $270 +1 FREE 8GB USB 0.2 mL / $315 +1 FREE 8GB USB 5x0.2 mL / $1,245 +1 FREE 8GB USB Previous Next Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name FRS2, Polyclonal Antibody Popular Item Full Product Name Phospho-FRS2 (Tyr436) Antibody Product Synonym Names FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS 2; FRS2; FRS2_HUMAN; FRS2A; FRS2alpha; SNT 1; SNT; SNT-1; SNT1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1 Product Gene Name anti-FRS2 antibody[Similar Products] Antibody/Peptide Pairs FRS2 (Tyr436) peptide (MBS9615818) is used for blocking the activity of FRS2 (Tyr436) antibody (MBS9601235) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP 3D Structure ModBase 3D Structure for Q8WU20 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Human, Mouse Specificity Phospho-FRS2 (Tyr436) antibody detects endogenous levels of FRS2 only when phosphorylated at Tyrosine 436 Purity/Purification From purified rabbit serum by affinity purification via sequential chromatography on phospho-and non-phospho-peptide affinity columns. Form/Format LiquidPhosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Concentration 1mg/ml (lot specific) Immunogen A synthesized peptide derived from human FRS2 around the phosphorylation site of Tyrosine 436 Subcellular Location Endomembrane System. Cytoplasmic, Membrane-Bound. Tissue Specificity Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Predicted Cross Reactivity Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (92%) Conjugation Unconjugated Epitope Phospho Tyr436 Preparation and Storage Store at -20 degree C. Stable for 12 months from date of receipt. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Supply Chain Verification Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire. Other Notes Small volumes of anti-FRS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-FRS2 antibody Description: FRS2 is an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.Function: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.Subunit Structure: Part of a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Part of a complex containing GRB2 and CBL. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds RET (By similarity). Binds ALK, FGFR1, CKS2, MAPK1/ERK2, MAPK3/ERK1 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11. Interacts with NTRK1, NTRK2 and NTRK3 (phosphorylated upon ligand-binding).Post-translational Modifications: Phosphorylated by ULK2 in vitro (By similarity). Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity). Applications Tested/Suitable for anti-FRS2 antibody Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) Application Notes for anti-FRS2 antibody WB: 1:500-1:2000IHC: 1:50-1:200 Western Blot (WB) of anti-FRS2 antibody Western blot analysis of FRS2 phosphorylation expression in Hela whole cell lysates, The lane on the right is treated with the antigen-specific peptide. Immunohistochemistry (IHC) of anti-FRS2 antibody Phospho-FRS2 (Tyr436) Antibody for IHC in human brain tissue Western Blot (WB) of anti-FRS2 antibody Western blot analysis of FRS2 phosphorylation expression in COS7 whole cell lysates, The lane on the left is treated with the antigen-specific peptide. TOP NCBI/Uniprot data below describe general gene information for FRS2. It may not necessarily be applicable to this product. NCBI GI # 110347414 NCBI GeneID 10818 NCBI Accession # NP_001036020.1 [Other Products] NCBI GenBank Nucleotide # NM_001042555.2 [Other Products] UniProt Primary Accession # Q8WU20 [Other Products] UniProt Secondary Accession # O43558; Q7LDQ6; B0LPF2; B2R684[Other Products] UniProt Related Accession # Q8WU20[Other Products] Molecular Weight Observed: 65 kDaPredicted: 58 kDa TOP NCBI Official Full Name fibroblast growth factor receptor substrate 2 NCBI Official Synonym Full Names fibroblast growth factor receptor substrate 2 NCBI Official Symbol FRS2 [Similar Products] NCBI Official Synonym Symbols SNT; SNT1; FRS1A; FRS2A; SNT-1; FRS2alpha [Similar Products] NCBI Protein Information fibroblast growth factor receptor substrate 2 UniProt Protein Name Fibroblast growth factor receptor substrate 2 UniProt Synonym Protein Names FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1 Protein Family Fibroblast growth factor receptor substrate UniProt Gene Name FRS2 [Similar Products] UniProt Synonym Gene Names FGFR substrate 2; SNT-1 [Similar Products] TOP TOP UniProt Comments for FRS2 Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Research Articles on FRS2 1. These findings suggest that FRS2 is amplified consistently in liposarcoma. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-FRS2 antibody Reference Product PubMed Publications FGFR1 antibody >41 publications with FRS2 and FGFR1 GRB2 antibody >37 publications with FRS2 and GRB2 SRC antibody >31 publications with FRS2 and SRC MAPK1 antibody >13 publications with FRS2 and MAPK1 PTPN11 antibody >13 publications with FRS2 and PTPN11 NTRK1 antibody >11 publications with FRS2 and NTRK1 RET antibody >10 publications with FRS2 and RET GAB1 antibody >9 publications with FRS2 and GAB1 CBL antibody >6 publications with FRS2 and CBL CRK antibody >4 publications with FRS2 and CRK Pathways associated with anti-FRS2 antibody Products by Pathway Pathway Diagram Adaptive Immune System Pathway antibodies Adaptive Immune System Pathway Diagram BDNF Signaling Pathway antibodies BDNF Signaling Pathway Diagram Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram DAP12 Interactions Pathway antibodies DAP12 Interactions Pathway Diagram DAP12 Signaling Pathway antibodies DAP12 Signaling Pathway Diagram Disease Pathway antibodies Disease Pathway Diagram Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram Downstream Signal Transduction Pathway antibodies Downstream Signal Transduction Pathway Diagram Downstream Signaling Of Activated FGFR Pathway antibodies Downstream Signaling Of Activated FGFR Pathway Diagram FGF Signaling Pathway antibodies FGF Signaling Pathway Diagram Diseases associated with anti-FRS2 antibody Disease Name Pubmed Publications Neoplasms Antibodies >45 publications with FRS2 and Neoplasms Death Antibodies >9 publications with FRS2 and Death Bone Diseases Antibodies >7 publications with FRS2 and Bone Diseases Breast Neoplasms Antibodies >5 publications with FRS2 and Breast Neoplasms Genital Diseases, Male Antibodies >5 publications with FRS2 and Genital Diseases, Male Immune System Diseases Antibodies >3 publications with FRS2 and Immune System Diseases Cardiovascular Diseases Antibodies >3 publications with FRS2 and Cardiovascular Diseases Liver Diseases Antibodies >2 publications with FRS2 and Liver Diseases Carcinoma, Hepatocellular Antibodies >2 publications with FRS2 and Carcinoma, Hepatocellular Atherosclerosis Antibodies >2 publications with FRS2 and Atherosclerosis Organs/Tissues associated with anti-FRS2 antibody Organ/Tissue Name Pubmed Publications Brain Antibodies >19 publications with FRS2 and Brain Vascular Antibodies >10 publications with FRS2 and Vascular Lung Antibodies >7 publications with FRS2 and Lung Muscle Antibodies >7 publications with FRS2 and Muscle Embryonic Tissue Antibodies >6 publications with FRS2 and Embryonic Tissue Liver Antibodies >5 publications with FRS2 and Liver Prostate Antibodies >5 publications with FRS2 and Prostate Kidney Antibodies >4 publications with FRS2 and Kidney Blood Antibodies >4 publications with FRS2 and Blood Stomach Antibodies >3 publications with FRS2 and Stomach TOP © 2006-24 MyBioSource.com. 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