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anti-FYN antibody :: Rabbit anti-Human FYN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7005454
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FYN, Polyclonal Antibody

★Popular Item★
 Also Known As   

FYN Antibody

 Product Synonym Names    Tyrosine-protein kinase Fyn (EC:2.7.10.2); FYN; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
 Product Gene Name   

anti-FYN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137025
 3D Structure    ModBase 3D Structure for P06241
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Affinity Purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Tyrosine-protein kinase Fyn protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30678 / sc-30680 / sc-51598 / sc-71133 / sc-73388 / sc-28791 / sc-16
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FYN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FYN antibody

   Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
 Applications Tested/Suitable for anti-FYN antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-FYN antibody    Recommended dilution: IHC: 1:20-1:200
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 Immunohistochemistry (IHC) of anti-FYN antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS7005454 at dilution of 1:100
anti-FYN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FYN. It may not necessarily be applicable to this product.
 NCBI GI #    4503823
 NCBI GeneID    2534
 NCBI Accession #    NP_002028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002037.5 [Other Products]
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 UniProt Primary Accession #    P06241 [Other Products]
 UniProt Secondary Accession #    Q16248; Q5R3A6; Q5R3A7; Q8N5D7; B5BU57; E1P557; H0UI48 [Other Products]
 UniProt Related Accession #    P06241 [Other Products]
 Molecular Weight    54,513 Da
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 NCBI Official Full Name    tyrosine-protein kinase Fyn isoform a
 NCBI Official Synonym Full Names    FYN proto-oncogene, Src family tyrosine kinase
 NCBI Official Symbol    FYN [Similar Products]
 NCBI Official Synonym Symbols   
SLK; SYN; p59-FYN
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Fyn
 UniProt Protein Name    Tyrosine-protein kinase Fyn
 UniProt Synonym Protein Names   
Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
 Protein Family    FYN-binding protein
 UniProt Gene Name    FYN [Similar Products]
 UniProt Synonym Gene Names    SLK [Similar Products]
 UniProt Entry Name    FYN_HUMAN
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 NCBI Summary for FYN    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FYN    Fyn: a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Oncoprotein; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: actin filament; cytosol; endosome; extrinsic to internal side of plasma membrane; lipid raft; mitochondrion; nucleus; plasma membrane; postsynaptic density

Molecular Function: ATP binding; CD4 receptor binding; CD8 receptor binding; ephrin receptor binding; G-protein-coupled receptor binding; glycoprotein binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; peptide hormone receptor binding; phosphoinositide 3-kinase binding; protein binding; protein-tyrosine kinase activity; T cell receptor binding; tubulin binding

Biological Process: activated T cell proliferation; activation of MAPKK activity; adaptive immune response; axon guidance; blood coagulation; calcium ion transport; cell differentiation; cell migration; dendrite morphogenesis; detection of mechanical stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; feeding behavior; fibroblast growth factor receptor signaling pathway; forebrain development; innate immune response; insulin receptor signaling pathway; learning; leukocyte migration; MAPKKK cascade; negative regulation of neuron apoptosis; negative regulation of protein catabolic process; negative regulation of protein ubiquitination; nerve growth factor receptor signaling pathway; neuron migration; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of Stat5 protein; protein amino acid phosphorylation; Ras protein signal transduction; regulation of apoptosis; regulation of cell proliferation; regulation of cell shape; regulation of defense response to virus by virus; response to drug; response to ethanol; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; viral reproduction
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 Research Articles on FYN    1. Fyn inhibition may be an effective therapeutic approach in treating cSCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FYN antibodyPathways associated with anti-FYN antibody
 Reference Product  PubMed Publications
 CBL antibody  >67 publications with FYN and CBL
 FYB antibody  >49 publications with FYN and FYB
 CTNNB1 antibody  >28 publications with FYN and CTNNB1
 CD36 antibody  >24 publications with FYN and CD36
 SHC1 antibody  >15 publications with FYN and SHC1
 BCAR1 antibody  >14 publications with FYN and BCAR1
 KHDRBS1 antibody  >12 publications with FYN and KHDRBS1
 SNCA antibody  >2 publications with FYN and SNCA
 GRIN2B antibody  >1 publications with FYN and GRIN2B
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with anti-FYN antibodyOrgans/Tissues associated with anti-FYN antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >215 publications with FYN and Immune System Diseases
 Nervous System Diseases Antibodies  >204 publications with FYN and Nervous System Diseases
 Inflammation Antibodies  >92 publications with FYN and Inflammation
 Breast Neoplasms Antibodies  >50 publications with FYN and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >50 publications with FYN and Cell Transformation, Neoplastic
 Necrosis Antibodies  >49 publications with FYN and Necrosis
 Neoplasms, Experimental Antibodies  >40 publications with FYN and Neoplasms, Experimental
 Kidney Diseases Antibodies  >34 publications with FYN and Kidney Diseases
 Lung Diseases Antibodies  >33 publications with FYN and Lung Diseases
 Neoplasm Metastasis Antibodies  >24 publications with FYN and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >481 publications with FYN and Brain
 Nerve Antibodies  >215 publications with FYN and Nerve
 Vascular Antibodies  >113 publications with FYN and Vascular
 Bone Antibodies  >95 publications with FYN and Bone
 Muscle Antibodies  >95 publications with FYN and Muscle
 Kidney Antibodies  >88 publications with FYN and Kidney
 Thymus Antibodies  >76 publications with FYN and Thymus
 Lung Antibodies  >69 publications with FYN and Lung
 Liver Antibodies  >62 publications with FYN and Liver
 Spleen Antibodies  >53 publications with FYN and Spleen
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