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anti-FZD1 antibody :: Rabbit anti-Human FZD1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7053361
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FZD1, Polyclonal Antibody

★Popular Item★
 Also Known As   

FZD1 Antibody

 Product Synonym Names    Frizzled-1; Fz-1; hFz1; FzE1; FZD1
 Product Gene Name   

anti-FZD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF072872 mRNA
 3D Structure    ModBase 3D Structure for Q9UP38
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Frizzled-1 protein (73-322AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FZD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FZD1 antibody

   Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
 Applications Tested/Suitable for anti-FZD1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-FZD1 antibody    IHC: 1:20-1:200
IF: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-FZD1 antibody    Immunohistochemistry of paraffin-embedded human prostate cancer using MBS7053361 at dilution of 1:100
anti-FZD1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FZD1 antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7053361 at dilution of 1:100
anti-FZD1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FZD1 antibody    Immunofluorescent analysis of MCF-7 cells using MBS7053361 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-FZD1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FZD1. It may not necessarily be applicable to this product.
 NCBI GI #    4503825
 NCBI GeneID    8321
 NCBI Accession #    NP_003496.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003505.1 [Other Products]
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 UniProt Primary Accession #    Q9UP38 [Other Products]
 UniProt Secondary Accession #    O94815; Q549T8; A4D1E8 [Other Products]
 UniProt Related Accession #    Q9UP38 [Other Products]
 Molecular Weight    71,158 Da
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 NCBI Official Full Name    frizzled-1
 NCBI Official Synonym Full Names    frizzled class receptor 1
 NCBI Official Symbol    FZD1 [Similar Products]
 NCBI Protein Information    frizzled-1
 UniProt Protein Name    Frizzled-1
 UniProt Synonym Protein Names   
FzE1
 Protein Family    Frizzled
 UniProt Gene Name    FZD1 [Similar Products]
 UniProt Synonym Gene Names    Fz-1; hFz1 [Similar Products]
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 NCBI Summary for FZD1    Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FZD1    FZD1: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q21.13

Cellular Component: cell surface; focal adhesion; integral to membrane; plasma membrane

Molecular Function: frizzled binding; G-protein coupled receptor activity; PDZ domain binding; protein binding; receptor binding; Wnt receptor activity; Wnt-protein binding

Biological Process: cell-cell signaling; neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; response to drug; Wnt receptor signaling pathway through beta-catenin; Wnt receptor signaling pathway, planar cell polarity pathway
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 Research Articles on FZD1    1. The amplification of miR-135b suppressed non-small cell lung cancer chemoresistance by directly mediating FZD1 down-regulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FZD1 antibodyPathways associated with anti-FZD1 antibody
 Reference Product  PubMed Publications
 WNT5A antibody  >20 publications with FZD1 and WNT5A
 WNT3A antibody  >19 publications with FZD1 and WNT3A
 WNT3 antibody  >19 publications with FZD1 and WNT3
 WNT2 antibody  >9 publications with FZD1 and WNT2
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
Diseases associated with anti-FZD1 antibodyOrgans/Tissues associated with anti-FZD1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >29 publications with FZD1 and Neoplasms
 Breast Neoplasms Antibodies  >7 publications with FZD1 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >5 publications with FZD1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >4 publications with FZD1 and Inflammation
 Death Antibodies  >4 publications with FZD1 and Death
 Hyperplasia Antibodies  >3 publications with FZD1 and Hyperplasia
 Carcinoma, Hepatocellular Antibodies  >2 publications with FZD1 and Carcinoma, Hepatocellular
 Leukemia Antibodies  >2 publications with FZD1 and Leukemia
 Colonic Neoplasms Antibodies  >2 publications with FZD1 and Colonic Neoplasms
 Disease Models, Animal Antibodies  >2 publications with FZD1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with FZD1 and Bone
 Embryonic Tissue Antibodies  >14 publications with FZD1 and Embryonic Tissue
 Brain Antibodies  >12 publications with FZD1 and Brain
 Connective Tissue Antibodies  >8 publications with FZD1 and Connective Tissue
 Muscle Antibodies  >8 publications with FZD1 and Muscle
 Lung Antibodies  >8 publications with FZD1 and Lung
 Kidney Antibodies  >7 publications with FZD1 and Kidney
 Blood Antibodies  >6 publications with FZD1 and Blood
 Uterus Antibodies  >6 publications with FZD1 and Uterus
 Heart Antibodies  >6 publications with FZD1 and Heart
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