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anti-FZD3 antibody :: Rabbit anti-Human, Mouse FZD3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2527526
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FZD3, Polyclonal Antibody

★Popular Item★
 Also Known As   

FZD3 Polyclonal Antibody

 Product Synonym Names    Fz-3
 Product Gene Name   

anti-FZD3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606143
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Affinity purification
 Concentration    0.1mg/mL (lot specific)
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FZD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FZD3 antibody

   Background/Introduction: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia.
 Product Categories/Family for anti-FZD3 antibody    Stem cells
 Applications Tested/Suitable for anti-FZD3 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-FZD3 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-FZD3 antibody    Immunohistochemistry of paraffin-embedded Human lung cancer tissue using FZD3 Polyclonal Antibody at dilution 1:20
anti-FZD3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FZD3 antibody    Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using FZD3 Polyclonal Antibody at dilution 1:20
anti-FZD3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FZD3. It may not necessarily be applicable to this product.
 NCBI GI #    313851102
 NCBI GeneID    7976
 NCBI Accession #    NP_665873.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_145866.1 [Other Products]
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 UniProt Secondary Accession #    A8K615 [Other Products]
 UniProt Related Accession #    Q9NPG1 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    frizzled-3
 NCBI Official Synonym Full Names    frizzled class receptor 3
 NCBI Official Symbol    FZD3 [Similar Products]
 NCBI Official Synonym Symbols   
Fz-3
[Similar Products]
 NCBI Protein Information    frizzled-3; frizzled 3, seven transmembrane spanning receptor; frizzled family receptor 3; frizzled homolog 3
 UniProt Protein Name    Frizzled-3
 UniProt Gene Name    FZD3 [Similar Products]
 UniProt Synonym Gene Names    Fz-3; hFz3 [Similar Products]
 UniProt Entry Name    FZD3_HUMAN
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 NCBI Summary for FZD3    This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
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 UniProt Comments for FZD3    FZD3: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, Fz/Smo family

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: cell surface; cell soma; axon; cytoplasm; apical plasma membrane; dendrite; integral to membrane; plasma membrane; presynaptic active zone; lateral plasma membrane

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding; PDZ domain binding

Biological Process: neuron differentiation; G-protein coupled receptor protein signaling pathway; positive regulation of neuroblast proliferation; inner ear morphogenesis; hair follicle development; neural tube closure; neuron migration; establishment of planar polarity; Wnt receptor signaling pathway through beta-catenin; cell proliferation in midbrain; negative regulation of mitotic cell cycle, embryonic
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 Research Articles on FZD3    1. Aberrant methylation modification of the FZD3 gene increases the risk of congenital hydrocephalus by altering chromatin structure and disturbing gene expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FZD3 antibodyPathways associated with anti-FZD3 antibody
 Reference Product  PubMed Publications
 WNT5A antibody  >16 publications with FZD3 and WNT5A
 WNT3A antibody  >9 publications with FZD3 and WNT3A
 LRP5 antibody  >8 publications with FZD3 and LRP5
 WNT7A antibody  >7 publications with FZD3 and WNT7A
 WNT11 antibody  >7 publications with FZD3 and WNT11
 DVL2 antibody  >7 publications with FZD3 and DVL2
 LRP6 antibody  >6 publications with FZD3 and LRP6
 WNT2B antibody  >5 publications with FZD3 and WNT2B
 DVL3 antibody  >4 publications with FZD3 and DVL3
 DVL1 antibody  >3 publications with FZD3 and DVL1
 Products by Pathway  Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-FZD3 antibodyOrgans/Tissues associated with anti-FZD3 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >11 publications with FZD3 and Congenital Abnormalities
 Central Nervous System Diseases Antibodies  >6 publications with FZD3 and Central Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with FZD3 and Brain Diseases
 Nervous System Malformations Antibodies  >5 publications with FZD3 and Nervous System Malformations
 Neural Tube Defects Antibodies  >5 publications with FZD3 and Neural Tube Defects
 Neurobehavioral Manifestations Antibodies  >4 publications with FZD3 and Neurobehavioral Manifestations
 Carcinoma, Hepatocellular Antibodies  >3 publications with FZD3 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >3 publications with FZD3 and Disease Models, Animal
 Abnormalities, Multiple Antibodies  >3 publications with FZD3 and Abnormalities, Multiple
 Liver Neoplasms Antibodies  >2 publications with FZD3 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >35 publications with FZD3 and Brain
 Nerve Antibodies  >18 publications with FZD3 and Nerve
 Embryonic Tissue Antibodies  >14 publications with FZD3 and Embryonic Tissue
 Lung Antibodies  >10 publications with FZD3 and Lung
 Skin Antibodies  >8 publications with FZD3 and Skin
 Kidney Antibodies  >6 publications with FZD3 and Kidney
 Testis Antibodies  >5 publications with FZD3 and Testis
 Eye Antibodies  >5 publications with FZD3 and Eye
 Stomach Antibodies  >5 publications with FZD3 and Stomach
 Ear Antibodies  >4 publications with FZD3 and Ear
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