Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow FZD5 rightarrow Polyclonal FZD5  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Interferon Gamma (IFNg) Recombinant Protein
 • RIP Antibody
 • Chondroitin epitopes 5d4 (CE 5d4) ELISA Kit
 • Epinephrine (EPI) Antibody
 • SYTL4 Antibody
 • Cerebellin 1 (CBLN1) ELISA Kit
 • Interferon beta, IFN-beta-IFNB ELISA Kit
 • AGTR1 Antibody
 • Histone H3K27me3 (HIST3H3) Antibody
 • Advanced Glycation End Product (AGE) ELISA Kit
 • Insulin ELISA Kit
 • Cdc2L5 (CDK13) Antibody
 • Desmin Antibody
 • Carbonic Anhydrase 9 (CA-9) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-FZD5 antibody :: Rabbit FZD5 / Frizzled 5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240934
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FZD5 / Frizzled 5, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human FZD5 / Frizzled 5

 Product Synonym Names    Anti-FZD5 / Frizzled 5 Antibody (N-Terminus) IHC-plus; FZD5; C2orf31; DKFZP434E2135; Frizzled family receptor 5; Fz5; Fzd-5; FzE5; Frizzled 5; Frizzled-5; Wnt receptor; Fz-5; HFZ5; Human FZD5; Frizzled 5
 Product Gene Name   

anti-FZD5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    601723
 3D Structure    ModBase 3D Structure for Q13467
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Bovine, Dog, Gorilla, Human, Monkey, Pig, Rabbit
Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
Section Bar
 Specificity    Human FZD5 / Frizzled 5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Synthetic 14 amino acid peptide from N-terminal extracellular domain of human FZD5 / Frizzled 5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Bovine, Elephant, Rabbit, Pig (100%); Mouse, Rat.
 Immunogen Type    Synthetic peptide
 Immunogen    FZD5 / Frizzled 5 antibody was raised against synthetic 14 amino acid peptide from N-terminal extracellular domain of human FZD5 / Frizzled 5. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Bovine, Elephant, Rabbit, Pig (100%); Mouse, Rat, Hamster (93%); Opossum (86%).
 Antigen Modification    N-Terminus
Section Bar
 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-FZD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-FZD5 antibody

   FZD5 is a Frizzled Receptor that mediates Wnt signaling. FZD5 is associated with limb bud and bone marrow stem cell development. FZD5 contributes to the activated state of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Recently, FZD5 has been implicated in melanoma metastasis through the Wnt5a and PKC pathway.
 Product Categories/Family for anti-FZD5 antibody    Family: GPCR
Subfamily: Frizzled
 Applications Tested/Suitable for anti-FZD5 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-FZD5 antibody    ELISA, IHC-P (7 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Section Bar
 Immunohistochemistry (IHC) of anti-FZD5 antibody    Anti-FZD5 / Frizzled 5 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FZD5 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for FZD5. It may not necessarily be applicable to this product.
 NCBI GI #    27894385
 NCBI GeneID    7855
 NCBI Accession #    NP_003459.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003468.3 [Other Products]
Section Bar
 UniProt Primary Accession #    Q13467 [Other Products]
 UniProt Secondary Accession #    Q53R22; A8K2X1; B2RCZ1 [Other Products]
 UniProt Related Accession #    Q13467 [Other Products]
 Molecular Weight    64,507 Da
Table BarTOPTable Bar
 NCBI Official Full Name    frizzled-5
 NCBI Official Synonym Full Names    frizzled class receptor 5
 NCBI Official Symbol    FZD5 [Similar Products]
 NCBI Official Synonym Symbols   
HFZ5; C2orf31
[Similar Products]
 NCBI Protein Information    frizzled-5; fz-5; fzE5; Wnt receptor; frizzled family receptor 5; seven-transmembrane receptor frizzled-5; frizzled 5, seven transmembrane spanning receptor
 UniProt Protein Name    Frizzled-5
 UniProt Synonym Protein Names   
FzE5
 Protein Family    Frizzled
 UniProt Gene Name    FZD5 [Similar Products]
 UniProt Synonym Gene Names    C2orf31; Fz-5; hFz5 [Similar Products]
 UniProt Entry Name    FZD5_HUMAN
Section Bar
 NCBI Summary for FZD5    Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for FZD5    FZD5: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. Interacts with GOPC. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Membrane protein, multi-pass; GPCR, Fz/Smo family; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: Golgi membrane; cell surface; tight junction; early endosome membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; protein binding; ubiquitin protein ligase binding; protein kinase binding

Biological Process: positive regulation of JNK activity; post-embryonic camera-type eye development; embryonic axis specification; cell maturation; T cell differentiation in the thymus; Wnt receptor signaling pathway through beta-catenin; embryonic camera-type eye development; neuron differentiation; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; determination of anterior/posterior axis, embryo; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; Spemann organizer formation
Table BarTOPTable Bar
 Research Articles on FZD5    1. data (i) support previous the assumption that CK1 acts via phosphorylation of distinct residues as the activator as well as the shut-off signal of Wnt/beta-catenin signaling and (ii) suggest that CK1 acts on Dvl via different mechanism than Fzd5
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-FZD5 antibodyPathways associated with anti-FZD5 antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >41 publications with FZD5 and CTNNB1
 WNT5A antibody  >31 publications with FZD5 and WNT5A
 WNT3A antibody  >11 publications with FZD5 and WNT3A
 WNT7A antibody  >10 publications with FZD5 and WNT7A
 LRP6 antibody  >10 publications with FZD5 and LRP6
 DVL2 antibody  >3 publications with FZD5 and DVL2
 DVL3 antibody  >1 publications with FZD5 and DVL3
 Products by Pathway  Pathway Diagram
 Asymmetric Localization Of PCP Proteins Pathway antibodies  Asymmetric Localization Of PCP Proteins Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-FZD5 antibodyOrgans/Tissues associated with anti-FZD5 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with FZD5 and Inflammation
 Adenocarcinoma Antibodies  >4 publications with FZD5 and Adenocarcinoma
 Nervous System Diseases Antibodies  >3 publications with FZD5 and Nervous System Diseases
 Ovarian Neoplasms Antibodies  >3 publications with FZD5 and Ovarian Neoplasms
 Pain Antibodies  >2 publications with FZD5 and Pain
 Breast Neoplasms Antibodies  >2 publications with FZD5 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with FZD5 and Cell Transformation, Neoplastic
 Lung Diseases Antibodies  >2 publications with FZD5 and Lung Diseases
 Liver Diseases Antibodies  >2 publications with FZD5 and Liver Diseases
 Hyperplasia Antibodies  >2 publications with FZD5 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >15 publications with FZD5 and Eye
 Bone Antibodies  >12 publications with FZD5 and Bone
 Embryonic Tissue Antibodies  >12 publications with FZD5 and Embryonic Tissue
 Brain Antibodies  >9 publications with FZD5 and Brain
 Lung Antibodies  >7 publications with FZD5 and Lung
 Kidney Antibodies  >5 publications with FZD5 and Kidney
 Pancreas Antibodies  >5 publications with FZD5 and Pancreas
 Intestine Antibodies  >5 publications with FZD5 and Intestine
 Uterus Antibodies  >5 publications with FZD5 and Uterus
 Skin Antibodies  >5 publications with FZD5 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions