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anti-F9 antibody :: Goat Factor IX Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512032 anti-F9 antibody
Unit / Price
0.1 mg  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor IX (F9), Polyclonal Antibody

 Also Known As   

Goat anti-human F.IX, APIgG-peroxidase

 Product Synonym Names    Factor IX, human
 Product Gene Name   

anti-F9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (138612895..138645617). Location: Xq27.1-q27.2
 OMIM    300746
 3D Structure    ModBase 3D Structure for P00740
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 Clonality    Polyclonal
 Host    Goat
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 Purity/Purification    Affinity purified, peroxidase conj. IgG
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 Other Notes    Small volumes of anti-F9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for F9. It may not necessarily be applicable to this product.
 NCBI GI #    182609
 NCBI GeneID    2158
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 UniProt Primary Accession #    P00740 [Other Products]
 UniProt Secondary Accession #    Q5JYJ8; A8K9N4 [Other Products]
 UniProt Related Accession #    P00740; Q14316; Q19UG1; Q19UG2; Q19UG3; Q19UG4; Q19UG5; Q19UG6; Q19UG8; Q19UG9 [Other Products]
 Molecular Weight    51,778 Da [Similar Products]
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 NCBI Official Full Name    factor IX
 NCBI Official Synonym Full Names    coagulation factor IX
 NCBI Official Symbol    F9 [Similar Products]
 NCBI Official Synonym Symbols   
FIX; P19; PTC; HEMB; MGC129641; MGC129642
[Similar Products]
 NCBI Protein Information    coagulation factor IX; FIX F9; factor 9; Christmas factor; OTTHUMP00000024154; plasma thromboplastic component; plasma thromboplastin component
 UniProt Protein Name    Coagulation factor IX
 UniProt Synonym Protein Names   
Christmas factor; Plasma thromboplastin component
 Protein Family    Coagulation factor
 UniProt Gene Name    F9 [Similar Products]
 UniProt Entry Name    FA9_HUMAN
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 NCBI Summary for F9    This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. [provided by RefSeq]
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 UniProt Comments for F9    Function: Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa.

Catalytic activity: Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.

Subunit structure: Heterodimer of a light chain and a heavy chain; disulfide-linked.

Subcellular location: Secreted.

Tissue specificity: Synthesized primarily in the liver and secreted in plasma.

Domain: Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.

Post-translational modification: Activated by factor XIa, which excises the activation peptide.The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

Involvement in disease: Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [

MIM:306900]; also known as Christmas disease. Ref.11 Ref.13 Ref.34 Ref.37 Ref.38 Ref.39 Ref.40 Ref.41 Ref.42 Ref.43 Ref.44 Ref.45 Ref.46 Ref.47 Ref.48 Ref.49 Ref.50 Ref.51 Ref.52 Ref.53 Ref.54 Ref.55 Ref.56 Ref.57 Ref.58 Ref.59 Ref.60 Ref.62 Ref.63 Ref.64 Ref.65 Ref.66 Ref.67 Ref.70 Ref.71 Ref.72Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [

MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis. Ref.73

Pharmaceutical use: Available under the name BeneFix (Baxter and American Home Products). Used to treat hemophilia B.

Miscellaneous: In 1952, one of the earliest researchers of the disease, Dr. R.G. Macfarlane used the patient's surname, Christmas, to refer to the disease and also to refer to the clotting factor which he called the 'Christmas Factor' At the time Stephen Christmas was a 5-year-old boy. He died in 1993 at the age of 46 from acquired immunodeficiency syndrome contracted through treatment with blood products.

Sequence similarities: Belongs to the peptidase S1 family.Contains 2 EGF-like domains.Contains 1 Gla (gamma-carboxy-glutamate) domain.Contains 1 peptidase S1 domain.
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 Research Articles on F9    1. three novel mutations in factor IX in patients with haemophilia B
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-F9 antibodyPathways associated with anti-F9 antibody
 Reference Product  PubMed Publications
 GGCX antibody  >1 publications with F9 and GGCX
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Extrinsic Pathway antibodies  Extrinsic Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
Diseases associated with anti-F9 antibodyOrgans/Tissues associated with anti-F9 antibody
 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >75 publications with F9 and Cell Transformation, Neoplastic
 Hemophilia B Antibodies  >54 publications with F9 and Hemophilia B
 Female Urogenital Diseases Antibodies  >32 publications with F9 and Female Urogenital Diseases
 Liver Diseases Antibodies  >26 publications with F9 and Liver Diseases
 Melanoma Antibodies  >24 publications with F9 and Melanoma
 Liver Neoplasms Antibodies  >23 publications with F9 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >23 publications with F9 and Neoplasm Metastasis
 Drug Toxicity Antibodies  >21 publications with F9 and Drug Toxicity
 Lung Neoplasms Antibodies  >17 publications with F9 and Lung Neoplasms
 Necrosis Antibodies  >16 publications with F9 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >94 publications with F9 and Liver
 Uncharacterized Tissue Antibodies  >1 publications with F9 and Uncharacterized Tissue
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