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anti-F5 antibody :: Sheep Factor V Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS512042 anti-F5 antibody
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor V (F5), Polyclonal Antibody

★Popular Item★
 Also Known As   

Sheep anti-human Factor V (FV), Biotinylated Affinity-Purified IgG

 Product Synonym Names    Factor V, human
 Product Gene Name   

anti-F5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (169481192..169555769, complement). Location: 1q23
 OMIM    188055
 3D Structure    ModBase 3D Structure for P12259
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 Clonality    Polyclonal
 Host    Sheep
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 Specificity    Prior to conjugation, this antibody was specific for factor V as demonstrated by immunoelectrophoresis and ELISA.
 Purity/Purification    Affinity purified, Biotinylated IgG.
Vial containing mL of affinity-purified IgG conjugated to biotin. Total protein is 0.1 mg.
 Form/Format    APIgG-biotin conjugate as a clear, colourless liquid.
 Concentration    APIgG-biotin concentration is mg/mL, determined by absorbance using an extinction coefficient (E1%280) of 14. (lot specific)
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 Immunogen    Human factor V purified from plasma.
 Buffer    Phosphate-buffered saline containing 1 mg/mL bovine albumin and 0.1% sodium azide, pH 7.4.
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 Preparation and Storage    Store at 2 degree C to 8 degree C.
 Other Notes    Small volumes of anti-F5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-F5 antibody

   Factor V (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320 kDa) that is produced in the liver. The gene that encodes factor V (FV) is located on chromosome 1. A congenital deficiency of FV is a hemorrhagic disorder inherited as an autosomal recessive disease. The concentration of FV in plasma is typically 10 ug/mL. FV is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the presence of phospholipid surface. Other physiologic activators of FV include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (FVa) is an essential component of the prothrombin activator complex, which consists of FVa, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more FV to FVa. Thrombin also acts to down-regulate FVa indirectly by activating Protein C, which inactivates FVa cofactor activity1-3.
 Application Notes for anti-F5 antibody    Suitable as a source of biotinylated antibodies to human factor V.
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NCBI/Uniprot data below describe general gene information for F5. It may not necessarily be applicable to this product.
 NCBI GI #    182798
 NCBI GeneID    2153
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 UniProt Primary Accession #    P12259 [Other Products]
 UniProt Secondary Accession #    Q14285; Q2EHR5; Q5R346; Q5R347; Q6UPU6; Q8WWQ6; A8K6E8 [Other Products]
 UniProt Related Accession #    P12259; Q15430; Q1L610; Q2HZY9; Q2HZZ0; Q2HZZ1; Q2I258; Q8IUL1; Q8TD21; Q8WWQ7 [Other Products]
 Molecular Weight    251,703 Da [Similar Products]
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 NCBI Official Full Name    factor V precusor
 NCBI Official Synonym Full Names    coagulation factor V (proaccelerin, labile factor)
 NCBI Official Symbol    F5 [Similar Products]
 NCBI Official Synonym Symbols   
FVL; PCCF
[Similar Products]
 NCBI Protein Information    coagulation factor V; factor V Leiden; OTTHUMP00000032547; OTTHUMP00000032548; proaccelerin, labile factor; activated protein c cofactor; coagulation factor V jinjiang A2 domain
 UniProt Protein Name    Coagulation factor V
 UniProt Synonym Protein Names   
Activated protein C cofactor; Proaccelerin, labile factor
 Protein Family    Factor V activator
 UniProt Gene Name    F5 [Similar Products]
 UniProt Entry Name    FA5_HUMAN
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 NCBI Summary for F5    This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq]
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 UniProt Comments for F5    Function: Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin.

Subunit structure: Factor Va, the activated form of factor V, is composed of a heavy chain and a light chain, non-covalently bound. The interaction between the two chains is calcium-dependent.

Subcellular location: Secreted

Tissue specificity: Plasma. Ref.18

Domain: Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats.

Post-translational modification: Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.Activated protein C inactivates factor V and factor Va by proteolytic degradation.Phosphorylation sites are present in the extracelllular medium.

Involvement in disease: Defects in F5 are the cause of factor V deficiency (FA5D) [

MIM:227400]; also known as Owren parahemophilia. It is an hemorrhagic diastesis. Ref.30 Ref.33Defects in F5 are the cause of thrombophilia due to activated protein C resistance (THR-APCR) [

MIM:188055]. THR-APCR is a hemostatic disorder due to defective degradation of factor Va by activated protein C. It is characterized by a poor anticoagulant response to activated protein C resulting in tendency to thrombosis. Ref.26 Ref.31 Ref.32 Ref.34 Ref.36Defects in F5 are a cause of susceptibility to Budd-Chiari syndrome (BCS) [

MIM:600880]. It is a syndrome caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava. Obstructions are generally caused by thrombosis and lead to hepatic congestion and ischemic necrosis. Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain and abdominal ascites. Budd-Chiari syndrome is associated with a combination of disease states including primary myeloproliferative syndromes and thrombophilia due to factor V Leiden, protein C deficiency and antithrombin III deficiency. Budd-Chiari syndrome is a rare but typical complication in patients with polycythemia vera.Defects in F5 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [

MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Ref.35

Sequence similarities: Belongs to the multicopper oxidase family.Contains 3 F5/8 type A domains.Contains 2 F5/8 type C domains.Contains 6 plastocyanin-like domains.

Sequence caution: The sequence ABD23003.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI23065.1 differs from that shown. Reason: Erroneous gene model prediction.
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Product References and Citations for anti-F5 antibody

   1. Kane WH, Davie EW; Blood Coagulation Factors V and VIII: Structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders. Blood 71:539, 1988.
2. Hoyer, LW, Wyshock EG, Colman RW, in Hemostasis and Thrombosis, 3rd Edition, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 109-133, J.B. Lippincott Co., Philadelphia, 1994.
3. Nesheim ME, Katzmann JA, Tracy PB, Mann KG; in Methods in Enzymology 80:249, 1980.
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 Research Articles on F5    1. When adjusted for nonsynonymous substitutions in F5 and FGA loci known to be associated with D-dimer levels, there was no evidence of an additional association at either locus
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-F5 antibodyPathways associated with anti-F5 antibody
 Reference Product  PubMed Publications
 F10 antibody  >27 publications with F5 and F10
 PROC antibody  >2 publications with F5 and PROC
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Formation Of Platelet Plug Pathway antibodies  Formation Of Platelet Plug Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation Pathway antibodies  Platelet Activation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
Diseases associated with anti-F5 antibodyOrgans/Tissues associated with anti-F5 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >59 publications with F5 and Nervous System Diseases
 Vascular Diseases Antibodies  >56 publications with F5 and Vascular Diseases
 Hematologic Diseases Antibodies  >47 publications with F5 and Hematologic Diseases
 Thrombosis Antibodies  >38 publications with F5 and Thrombosis
 Inflammation Antibodies  >23 publications with F5 and Inflammation
 Leukemia Antibodies  >21 publications with F5 and Leukemia
 Carcinoma Antibodies  >21 publications with F5 and Carcinoma
 Autoimmune Diseases Antibodies  >19 publications with F5 and Autoimmune Diseases
 Liver Diseases Antibodies  >19 publications with F5 and Liver Diseases
 Blood Coagulation Disorders Antibodies  >19 publications with F5 and Blood Coagulation Disorders
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >292 publications with F5 and Blood
 Brain Antibodies  >149 publications with F5 and Brain
 Liver Antibodies  >48 publications with F5 and Liver
 Thymus Antibodies  >40 publications with F5 and Thymus
 Intestine Antibodies  >29 publications with F5 and Intestine
 Kidney Antibodies  >27 publications with F5 and Kidney
 Heart Antibodies  >24 publications with F5 and Heart
 Lung Antibodies  >24 publications with F5 and Lung
 Embryonic Tissue Antibodies  >19 publications with F5 and Embryonic Tissue
 Eye Antibodies  >15 publications with F5 and Eye
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