AAD16051.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
factor X, partial
NCBI Official Synonym Full Names
coagulation factor X
NCBI Official Synonym Symbols
NCBI Protein Information
coagulation factor X
UniProt Protein Name
Coagulation factor X
UniProt Synonym Protein Names
Stuart factor
UniProt Entry Name
FA10_MOUSE
NCBI Summary for F10
This gene encodes factor X, a component of both the intrinsic and extrinsic blood coagulation pathways. The encoded protein is a zymogen that undergoes further processing in a vitamin K-dependent manner to generate mature factor X, a heterodimer comprised of disulfide-linked heavy and light chains. The mature factor X is proteolytically activated either by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway) to form factor Xa serine endopeptidase. Activated factor Xa catalyzes the conversion of prothrombin to thrombin. A complete lack of the encoded protein is fatal to mice. A severe deficiency of the encoded protein in mice causes age-dependent iron deposition and cardiac fibrosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
UniProt Comments for F10
F10: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Defects in F10 are the cause of factor X deficiency (FA10D). A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. Belongs to the peptidase S1 family.
Protein type: Secreted; Lipid-binding; EC 3.4.21.6; Motility/polarity/chemotaxis; Secreted, signal peptide; Protease
Cellular Component: intracellular membrane-bound organelle; membrane; extracellular region
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; phospholipid binding; calcium ion binding; catalytic activity
Biological Process: positive regulation of protein kinase B signaling cascade; hemostasis; blood coagulation; proteolysis
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Products associated with anti-F10 antibody
Pathways associated with anti-F10 antibody
Diseases associated with anti-F10 antibody
Organs/Tissues associated with anti-F10 antibody
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