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anti-F12 antibody :: Rabbit anti-Human, Mouse Factor XII HC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8242193
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Factor XII HC (F12), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Factor XII HC Antibody

 Product Synonym Names    Coagulation factor XII; Hageman factor; HAF
 Product Gene Name   

anti-F12 antibody

[Similar Products]
 Antibody/Peptide Pairs    Factor XII HC peptide (MBS8244378) is used for blocking the activity of Factor XII HC antibody (MBS8242193)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    234000
 3D Structure    ModBase 3D Structure for P00748
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes endogenous levels of Factor XII HC protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
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 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Factor XII HC. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-F12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-F12 antibody

   Rabbit polyclonal antibody to Factor XII HC
 Applications Tested/Suitable for anti-F12 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-F12 antibody    Western Blot: (1/500 - 1/1000); Immunohistochemistry: (1/100 - 1/200)
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 Western Blot (WB) of anti-F12 antibody    Western blot analysis of Factor XII HC expression in MDAMB435 (A), NIH3T3 (B) whole cell lysates.
anti-F12 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-F12 antibody    Immunohistochemical analysis of Factor XII HC staining in human kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugacompact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-F12 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for F12. It may not necessarily be applicable to this product.
 NCBI GI #    317373446
 NCBI GeneID    2161
 NCBI Accession #    P00748.3 [Other Products]
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 UniProt Primary Accession #    P00748 [Other Products]
 UniProt Secondary Accession #    P78339 [Other Products]
 UniProt Related Accession #    P00748 [Other Products]
 Molecular Weight    67,792 Da
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 NCBI Official Full Name    Coagulation factor XII
 NCBI Official Synonym Full Names    coagulation factor XII
 NCBI Official Symbol    F12 [Similar Products]
 NCBI Official Synonym Symbols   
HAF; HAE3; HAEX
[Similar Products]
 NCBI Protein Information    coagulation factor XII
 UniProt Protein Name    Coagulation factor XII
 UniProt Synonym Protein Names   
Hageman factor; HAF
 Protein Family    Coagulation factor
 UniProt Gene Name    F12 [Similar Products]
 UniProt Synonym Gene Names    HAF [Similar Products]
 UniProt Entry Name    FA12_HUMAN
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 NCBI Summary for F12    This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008]
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 UniProt Comments for F12    F12: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta- factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Defects in F12 are the cause of factor XII deficiency (FA12D); also known as Hageman factor deficiency. This trait is an asymptomatic anomaly of in vitro blood coagulation. Its diagnosis is based on finding a low plasma activity of the factor in coagulating assays. It is usually only accidentally discovered through pre-operative blood tests. F12 deficiency is divided into two categories, a cross-reacting material (CRM)-negative group (negative F12 antigen detection) and a CRM-positive group (positive F12 antigen detection). Defects in F12 are the cause of hereditary angioedema type 3 (HAE3); also known as estrogen-related HAE or hereditary angioneurotic edema with normal C1 inhibitor concentration and function. HAE is characterized by episodic local subcutaneous edema, and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE3 occurs exclusively in women and is precipitated or worsened by high estrogen levels (e.g. during pregnancy or treatment with oral contraceptives). It differs from HAE types 1 and 2 in that both concentration and function of C1 inhibitor are normal. Belongs to the peptidase S1 family.

Protein type: Protease; Secreted; Chaperone; EC 3.4.21.38; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function: misfolded protein binding; protein binding; serine-type endopeptidase activity

Biological Process: blood coagulation; blood coagulation, intrinsic pathway; Factor XII activation; fibrinolysis; innate immune response; plasma kallikrein-kinin cascade; positive regulation of blood coagulation; positive regulation of fibrinolysis; protein autoprocessing; protein processing; response to misfolded protein; zymogen activation

Disease: Angioedema, Hereditary, Type Iii; Factor Xii Deficiency
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 Research Articles on F12    1. Women with low FXII level might have an increased risk of premature delivery at < 34 GW.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-F12 antibodyPathways associated with anti-F12 antibody
 Reference Product  PubMed Publications
 F11 antibody  >38 publications with F12 and F11
 SERPING1 antibody  >12 publications with F12 and SERPING1
 KLKB1 antibody  >7 publications with F12 and KLKB1
 KNG1 antibody  >5 publications with F12 and KNG1
 GP1BA antibody  >5 publications with F12 and GP1BA
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway Of Fibrin Clot Formation antibodies  Intrinsic Pathway Of Fibrin Clot Formation Diagram
Diseases associated with anti-F12 antibodyOrgans/Tissues associated with anti-F12 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >76 publications with F12 and Cardiovascular Diseases
 Carcinoma Antibodies  >59 publications with F12 and Carcinoma
 Nervous System Diseases Antibodies  >56 publications with F12 and Nervous System Diseases
 Necrosis Antibodies  >30 publications with F12 and Necrosis
 Neoplasms, Experimental Antibodies  >28 publications with F12 and Neoplasms, Experimental
 Factor XII Deficiency Antibodies  >22 publications with F12 and Factor XII Deficiency
 Fibrosis Antibodies  >20 publications with F12 and Fibrosis
 Cell Transformation, Neoplastic Antibodies  >20 publications with F12 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >19 publications with F12 and Liver Diseases
 Angioedemas, Hereditary Antibodies  >18 publications with F12 and Angioedemas, Hereditary
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >107 publications with F12 and Brain
 Embryonic Tissue Antibodies  >90 publications with F12 and Embryonic Tissue
 Kidney Antibodies  >72 publications with F12 and Kidney
 Liver Antibodies  >70 publications with F12 and Liver
 Connective Tissue Antibodies  >54 publications with F12 and Connective Tissue
 Testis Antibodies  >47 publications with F12 and Testis
 Lung Antibodies  >46 publications with F12 and Lung
 Uterus Antibodies  >21 publications with F12 and Uterus
 Intestine Antibodies  >21 publications with F12 and Intestine
 Prostate Antibodies  >13 publications with F12 and Prostate
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