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anti-FADD antibody :: Rabbit Fas Associating Death Domain Containing Protein (FADD) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004183 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $185 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $825 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fas Associating Death Domain Containing Protein (FADD), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Fas Associating Death Domain Containing Protein (FADD)

 Product Gene Name   

anti-FADD antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- LLHS LSGSLSGNDL MELKFLCRER VSKRKLERVQ SGLDLFTVLL EQNDLERGHT GLLRELLASL RRHDLLQRLD DFEAGTATAA PPGEADLQVA FDIVCDNVGR DWKRLARELK VSEAKMDGIE EKYPRSLSER VRESLKVWKN AEKKNASVAG LVKALRTCRL NLVADLVE
 3D Structure    ModBase 3D Structure for Q61160
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mus musculus (Mouse)
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 Specificity    The antibody is a rabbit polyclonal antibody raised against FADD. It has been selected for its ability to recognize FADD in immunohistochemical staining andwestern blotting.
 Purity/Purification    Antigen-specific Affinity Chromatography.
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant Fas Associating Death Domain Containing Protein (FADD)
 Source    Polyclonal antibody preparation
 Traits    Liquid
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2081991
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-FADD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FADD antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB),IP, IF, FCM.

 Application Notes for anti-FADD antibody    Western blotting: 0.5-2ug/ml
Immunocytochemistry in formalin fixed cells: 5-20ug/ml
Immunohistochemistry in formalin fixed frozen section: 5-20ug/ml
Immunohistochemistry in paraffin section: 5-20ug/ml
Enzyme-linked Immunosorbent Assay: 0.05-2ug/ml
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-FADD antibody    (Figure. Western Blot; Sample: Human Serum.)
anti-FADD antibody Western Blot (WB) (WB) image
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 Testing Data of anti-FADD antibody    (Knockout Varification: Lane 1: Wild-type RaW264.7 cell lysate;;Lane 2: FADD knockout RaW264.7 cell lysate;;Predicted MW: 23kDa;Observed MW: 27kDa;Primary Ab: 1ug/ml Rabbit Anti-mouse FADD Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;)
anti-FADD antibody Testing Data image
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 Western Blot (WB) of anti-FADD antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-FADD antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FADD antibody    (Used in DAB staining on formalin fixed paraffin- embedded kidney tissue)
anti-FADD antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FADD. It may not necessarily be applicable to this product.
 NCBI GI #    6753812
 NCBI GeneID    14082
 NCBI Accession #    NP_034305.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_010175.5 [Other Products]
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 UniProt Primary Accession #    Q61160 [Other Products]
 UniProt Secondary Accession #    Q3TC37; Q61082 [Other Products]
 UniProt Related Accession #    Q61160 [Other Products]
 Molecular Weight    22,960 Da
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 NCBI Official Full Name    FAS-associated death domain protein
 NCBI Official Synonym Full Names    Fas (TNFRSF6)-associated via death domain
 NCBI Official Symbol    Fadd [Similar Products]
 NCBI Official Synonym Symbols   
Mort1/FADD
[Similar Products]
 NCBI Protein Information    FAS-associated death domain protein
 UniProt Protein Name    FAS-associated death domain protein
 UniProt Synonym Protein Names   
FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; Protein FADD
 Protein Family    Fas-associated death domain protein
 UniProt Gene Name    Fadd [Similar Products]
 UniProt Synonym Gene Names    Mort1 [Similar Products]
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 UniProt Comments for FADD    FADD: an adaptor molecule that mediates apoptosis. Recruited through its C-terminal death domain by Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TRAIL-receptor, participating in the death signaling initiated by these receptors. Interaction with the receptors unmasks the N-terminal effector domain of this protein, which recruits caspase-8, and thereby activates the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Protein type: Adaptor/scaffold; Apoptosis

Chromosomal Location of Human Ortholog: 7 F5|7 88.85 cM

Cellular Component: CD95 death-inducing signaling complex; cell body; cytoplasm; cytosol; membrane raft; neuron projection; nucleus; plasma membrane; protein complex

Molecular Function: caspase binding; death receptor binding; identical protein binding; protease binding; protein binding; protein complex binding; receptor serine/threonine kinase binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; cardiac muscle tissue development; defense response to virus; immune system process; innate immune response; lymph node development; positive regulation of activated T cell proliferation; positive regulation of adaptive immune response; positive regulation of apoptosis; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of interferon-gamma production; positive regulation of interleukin-8 production; positive regulation of macrophage differentiation; positive regulation of proteolysis; positive regulation of T cell mediated cytotoxicity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of apoptosis; response to morphine; signal transduction; spleen development; T cell differentiation; T cell differentiation in thymus; T cell homeostasis; thymus development; TRAIL-activated apoptotic signaling pathway
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 Research Articles on FADD    1. The authors conclude that FADD is a master regulator of glucose and fat metabolism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FADD antibodyPathways associated with anti-FADD antibody
 Reference Product  PubMed Publications
 Nol3 antibody  >6 publications with FADD and Nol3
 Products by Pathway  Pathway Diagram
 Activation Of Pro-Caspase 8 Pathway antibodies  Activation Of Pro-Caspase 8 Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Caspase-8 Is Formed From Procaspase-8 Pathway antibodies  Caspase-8 Is Formed From Procaspase-8 Pathway Diagram
Diseases associated with anti-FADD antibodyOrgans/Tissues associated with anti-FADD antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1060 publications with FADD and Necrosis
 Neoplasms Antibodies  >912 publications with FADD and Neoplasms
 Adenocarcinoma Antibodies  >127 publications with FADD and Adenocarcinoma
 Inflammation Antibodies  >114 publications with FADD and Inflammation
 Skin Diseases Antibodies  >110 publications with FADD and Skin Diseases
 Nervous System Diseases Antibodies  >94 publications with FADD and Nervous System Diseases
 Drug Toxicity Antibodies  >94 publications with FADD and Drug Toxicity
 Prostatic Diseases Antibodies  >76 publications with FADD and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >75 publications with FADD and Prostatic Neoplasms
 Liver Diseases Antibodies  >75 publications with FADD and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >511 publications with FADD and Blood
 Liver Antibodies  >121 publications with FADD and Liver
 Brain Antibodies  >101 publications with FADD and Brain
 Lung Antibodies  >95 publications with FADD and Lung
 Kidney Antibodies  >66 publications with FADD and Kidney
 Skin Antibodies  >64 publications with FADD and Skin
 Bone Antibodies  >57 publications with FADD and Bone
 Heart Antibodies  >50 publications with FADD and Heart
 Bone Marrow Antibodies  >38 publications with FADD and Bone Marrow
 Lymph Node Antibodies  >38 publications with FADD and Lymph Node
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