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anti-FAIM3 antibody :: Rabbit anti-Human Fas apoptotic inhibitory molecule 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1496626
Immunohistochemistry (IHC)
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fas apoptotic inhibitory molecule 3 (FAIM3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Fas apoptotic inhibitory molecule 3 polyclonal Antibody(FAIM3)

 Product Synonym Names    Regulator of Fas-induced apoptosis Toso; FAIM3; TOSO
 Product Gene Name   

anti-FAIM3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606015
 3D Structure    ModBase 3D Structure for O60667
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Fas apoptotic inhibitory molecule 3 protein (18-251aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8263
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FAIM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FAIM3 antibody

   May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
 Applications Tested/Suitable for anti-FAIM3 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-FAIM3 antibody    Recommended dilution: IHC:1:20-1:200
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 Immunohistochemistry (IHC) of anti-FAIM3 antibody    Immunohistochemistry of paraffin-embedded human placenta using MBS1496626 at dilution 1:100
anti-FAIM3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FAIM3. It may not necessarily be applicable to this product.
 NCBI GI #    216547554
 NCBI GeneID    9214
 NCBI Accession #    NP_001135945.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142473.1 [Other Products]
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 UniProt Primary Accession #    O60667 [Other Products]
 UniProt Secondary Accession #    A8K7J2; B7Z6Z0; D9MWM3 [Other Products]
 UniProt Related Accession #    O60667 [Other Products]
 Molecular Weight    33,828 Da
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 NCBI Official Full Name    fas apoptotic inhibitory molecule 3 isoform b
 NCBI Official Synonym Full Names    Fc fragment of IgM receptor
 NCBI Official Symbol    FCMR [Similar Products]
 NCBI Official Synonym Symbols   
TOSO; FAIM3
[Similar Products]
 NCBI Protein Information    fas apoptotic inhibitory molecule 3
 UniProt Protein Name    Fas apoptotic inhibitory molecule 3
 UniProt Synonym Protein Names   
IgM Fc fragment receptor
 Protein Family    Fas apoptotic inhibitory molecule
 UniProt Gene Name    FCMR [Similar Products]
 UniProt Entry Name    FAIM3_HUMAN
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 NCBI Summary for FAIM3    Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
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 UniProt Comments for FAIM3    FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: cellular defense response; immune system process; negative regulation of apoptosis
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 Research Articles on FAIM3    1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FAIM3 antibodyDiseases associated with anti-FAIM3 antibody
 Reference Product  PubMed Publications
 BCR antibody  >1 publications with FAIM3 and BCR
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with FAIM3 and Congenital Abnormalities
 Heart Diseases Antibodies  >1 publications with FAIM3 and Heart Diseases
 Disease Models, Animal Antibodies  >1 publications with FAIM3 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with FAIM3 and Kidney Diseases
 Chromosome Aberrations Antibodies  >1 publications with FAIM3 and Chromosome Aberrations
 Lung Diseases Antibodies  >1 publications with FAIM3 and Lung Diseases
Organs/Tissues associated with anti-FAIM3 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with FAIM3 and Blood
 Bone Marrow Antibodies  >1 publications with FAIM3 and Bone Marrow
 Spleen Antibodies  >1 publications with FAIM3 and Spleen
 Lymph Node Antibodies  >1 publications with FAIM3 and Lymph Node
 Lung Antibodies  >1 publications with FAIM3 and Lung
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