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anti-FBXL4 antibody :: Rabbit FbxL4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS177027
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

FbxL4, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-FbxL4 antibody

 Product Synonym Names    F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F box and leucine rich repeat protein 4 antibody; F box protein FBL4/FBL5 antibody; F box/LRR repeat protein 4 antibody; F-box and leucine-rich repeat protein 4 antibody; F-box protein FBL 4 antibody; F-box protein FBL4/FBL5 antibody; F-box/LRR-repeat protein 4 antibody; FBL 4 antibody; FBL 5 antibody; FBL4 antibody; FBL5 antibody; Fbxl4 antibody; FBXL4_HUMAN antibody
 Product Gene Name   

anti-FBXL4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 615471
 3D Structure    ModBase 3D Structure for Q9UKA2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Predicted: Human, Rat
Predicted to work with: Mouse
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 Specificity    No cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human FbxL4 (552-565aa DELASNCTRLQQLD), different from the related mouse and rat sequences by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FBXL4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-FBXL4 antibody

   Description: Rabbit IgG polyclonal antibody for F-box/LRR-repeat protein 4(FBXL4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: FBXL4, also known as FBL4 or FBL5 encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. This gene is mapped to 6q16.1. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A.
 Applications Tested/Suitable for anti-FBXL4 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-FBXL4 antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml
Tested Species: Hu
Predicted Species: Ms, Rat
Antigen Retrieval: By Heat

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sectsions in 10mM citrate buffer, pH6.0 for mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
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 Western Blot (WB) of anti-FBXL4 antibody    Anti-FbxL4 antibody, Western blotting
Lane 1: Rat Liver Tissue Lysate
Lane 2: Rat Lung Tissue Lysate
Lane 3: HELA Cell Lysate
Lane 4: PANC Cell Lysate
anti-FBXL4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FBXL4 antibody    Anti-FbxL4 antibody, IHC(P)
IHC(P): Human Lung Cancer Tissue
anti-FBXL4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FBXL4. It may not necessarily be applicable to this product.
 NCBI GI #    21263631
 NCBI GeneID    26235
 NCBI Accession #    Q9UKA2.2 [Other Products]
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 UniProt Primary Accession #    Q9UKA2 [Other Products]
 UniProt Secondary Accession #    O95919; Q5BJH0; Q9UJU0; B2R7Q5; E1P530 [Other Products]
 UniProt Related Accession #    Q9UKA2 [Other Products]
 Molecular Weight    70,097 Da
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 NCBI Official Full Name    F-box/LRR-repeat protein 4
 NCBI Official Synonym Full Names    F-box and leucine-rich repeat protein 4
 NCBI Official Symbol    FBXL4 [Similar Products]
 NCBI Official Synonym Symbols   
FBL4; FBL5; MTDPS13
[Similar Products]
 NCBI Protein Information    F-box/LRR-repeat protein 4
 UniProt Protein Name    F-box/LRR-repeat protein 4
 UniProt Synonym Protein Names   
F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5
 UniProt Gene Name    FBXL4 [Similar Products]
 UniProt Synonym Gene Names    FBL4; FBL5 [Similar Products]
 UniProt Entry Name    FBXL4_HUMAN
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 NCBI Summary for FBXL4    This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for FBXL4    FBXL4: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

Chromosomal Location of Human Ortholog: 6q16.1-q16.3

Cellular Component: nucleoplasm; mitochondrial intermembrane space; ubiquitin ligase complex

Biological Process: ubiquitin-dependent protein catabolic process

Disease: Mitochondrial Dna Depletion Syndrome 13 (encephalomyopathic Type)
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 Research Articles on FBXL4    1. These data strongly support a role for FBXL4 in controlling bioenergetic homeostasis and mtDNA maintenance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FBXL4 antibodyDiseases associated with anti-FBXL4 antibody
 Reference Product  PubMed Publications
 SKP1 antibody  >1 publications with FBXL4 and SKP1
 KDM4A antibody  >1 publications with FBXL4 and KDM4A
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with FBXL4 and Nervous System Diseases
 Atrophy Antibodies  >1 publications with FBXL4 and Atrophy
Organs/Tissues associated with anti-FBXL4 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with FBXL4 and Muscle
 Eye Antibodies  >1 publications with FBXL4 and Eye
 Blood Antibodies  >1 publications with FBXL4 and Blood
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