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anti-Fgf23 antibody :: Goat Fgf23 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422726
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fgf23, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Fgf23 (mouse) Antibody

 Product Synonym Names    Fgf23; fibroblast growth factor 23; ADHR; HPDR2; HYPF; PHPTC; FGF-23; phosphatonin; tumor-derived hypophosphatemia inducing factor; tumor-derived hypophosphatemia-inducing factor; ADHR antibody; FGF-23 antibody; fibroblast growth factor 23 antibody; HPDR2 antibody; HYPF antibody; phosphatonin antibody; PHPTC antibody; tumor-derived hypophosphatemia inducing factor antibody; tumor-derived hypophosphatemia-inducing factor antibody; Fgf23 antibody; Fgf23 (mouse)
 Product Gene Name   

anti-Fgf23 antibody

[Similar Products]
 Antibody/Peptide Pairs    Fgf23 peptide (MBS427488) is used for blocking the activity of Fgf23 antibody (MBS422726)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ENGYDVYLSQ KHH
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Mouse; Expected from sequence similarity: Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ENGYDVYLSQKHH, from the internal region of the protein sequence according to NP_073148.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-Fgf23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-Fgf23 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-Fgf23 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Approx 27+38kDa bands observed in Mouse Brain lysates (calculated MW of 27.7kDa according to NP_073148.1). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Garringer et al, Am J Physiol Endocrinol Metab.2008 Oct;295(4): E929-37. PMID: 18682534). Recommended concentration: 0.5-2ug/ml.
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 Western Blot (WB) of anti-Fgf23 antibody    (0.5ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-Fgf23 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Fgf23. It may not necessarily be applicable to this product.
 NCBI GI #    12083589
 NCBI GeneID    64654
 NCBI Accession #    NP_073148.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_022657.4 [Other Products]
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 UniProt Related Accession #    Q9EPC2 [Other Products]
 Molecular Weight    27,758 Da
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 NCBI Official Full Name    fibroblast growth factor 23
 NCBI Official Synonym Full Names    fibroblast growth factor 23
 NCBI Official Symbol    Fgf23 [Similar Products]
 NCBI Protein Information    fibroblast growth factor 23
 UniProt Protein Name    Fibroblast growth factor 23
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    Fgf23 [Similar Products]
 UniProt Synonym Gene Names    FGF-23 [Similar Products]
 UniProt Entry Name    FGF23_MOUSE
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 NCBI Summary for Fgf23    This gene encodes a member of the fibroblast growth factor family. The encoded protein regulates phosphate homeostasis and vitamin D metabolism. Mutation of the related gene in humans causes autosomal dominant hypophosphatemic rickets (ADHR). The secreted protein is further cleaved into N- and C-terminal chains, which results in loss of function. [provided by RefSeq, Mar 2013]
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 UniProt Comments for Fgf23    FGF23: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR). ADHR is characterized by low serum phosphorus concentrations, rickets, osteomalacia, leg deformities, short stature, bone pain and dental abscesses. Defects in FGF23 are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). HFTC is a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Belongs to the heparin-binding growth factors family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Cellular Component: extracellular region; extracellular space

Molecular Function: fibroblast growth factor receptor binding; growth factor activity; protein binding; type 1 fibroblast growth factor receptor binding

Biological Process: cell differentiation; cellular phosphate ion homeostasis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; phosphate ion homeostasis; positive regulation of transcription, DNA-dependent; regulation of bone mineralization; vitamin D catabolic process
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 Research Articles on Fgf23    1. findings revealed that FGF23 neutralization effectively improves bone quality and osseointegration of titanium implants in CKD mice, suggesting FGF23 as a key factor of CKD related bone diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Fgf23 antibodyPathways associated with anti-Fgf23 antibody
 Reference Product  PubMed Publications
 Fgfr1 antibody  >58 publications with Fgf23 and Fgfr1
 Fgfr4 antibody  >21 publications with Fgf23 and Fgfr4
 Fgfr3 antibody  >17 publications with Fgf23 and Fgfr3
 Fgfr2 antibody  >12 publications with Fgf23 and Fgfr2
 Fgf8 antibody  >7 publications with Fgf23 and Fgf8
 Fgf9 antibody  >7 publications with Fgf23 and Fgf9
 Fgf18 antibody  >5 publications with Fgf23 and Fgf18
 Fgf20 antibody  >4 publications with Fgf23 and Fgf20
 Fgf17 antibody  >2 publications with Fgf23 and Fgf17
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR1 Pathway antibodies  Downstream Signaling Of Activated FGFR1 Pathway Diagram
Diseases associated with anti-Fgf23 antibodyOrgans/Tissues associated with anti-Fgf23 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >577 publications with Fgf23 and Kidney Diseases
 Phosphorus Metabolism Disorders Antibodies  >319 publications with Fgf23 and Phosphorus Metabolism Disorders
 Rickets Antibodies  >312 publications with Fgf23 and Rickets
 Renal Insufficiency Antibodies  >274 publications with Fgf23 and Renal Insufficiency
 Hyperphosphatemia Antibodies  >186 publications with Fgf23 and Hyperphosphatemia
 Calcinosis Antibodies  >136 publications with Fgf23 and Calcinosis
 Hypertension Antibodies  >110 publications with Fgf23 and Hypertension
 Hypertrophy Antibodies  >62 publications with Fgf23 and Hypertrophy
 Death Antibodies  >59 publications with Fgf23 and Death
 Inflammation Antibodies  >47 publications with Fgf23 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >611 publications with Fgf23 and Blood
 Skin Antibodies  >35 publications with Fgf23 and Skin
 Spleen Antibodies  >6 publications with Fgf23 and Spleen
 Pancreas Antibodies  >5 publications with Fgf23 and Pancreas
 Inner Ear Antibodies  >1 publications with Fgf23 and Inner Ear
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