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anti-Fgfr1 antibody :: Rabbit anti-Human, mouse Fgfr1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9209911
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fgfr1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Mouse Fgfr1 Antibody (C-term)

 Product Synonym Names    Fibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD331; Fgfr1; Flg
 Product Gene Name   

anti-Fgfr1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Fgfr1 peptide (MBS9221153) is used for blocking the activity of Fgfr1 antibody (MBS9209911)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    756-784
 3D Structure    ModBase 3D Structure for P16092
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human, mouse
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 Specificity    This Mouse Fgfr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 756-784 amino acids from the C-terminal region of mouse Fgfr1.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    MOUSE
 Function    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity).
  Cellular Location    Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus Isoform 5: Cell membrane; Single-pass type I membrane protein
 Tissue Location    Widely expressed.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-Fgfr1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Fgfr1 antibody

   Receptor for basic fibroblast growth factor. A shorter form of the receptor could be a receptor for FGF1 (aFGF). Receptor for FGF23 in the presence of KL.
 Product Categories/Family for anti-Fgfr1 antibody    Cancer; Cardiovascular; Neuroscience; Signal Transduction
 Applications Tested/Suitable for anti-Fgfr1 antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-Fgfr1 antibody    WB~~1:1000
IHC-P~~1:10~50
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 Western Blot (WB) of anti-Fgfr1 antibody    Mouse Fgfr1 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the Fgfr1 antibody detected the Fgfr1 protein (arrow).
anti-Fgfr1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-Fgfr1 antibody    Mouse Fgfr1 Antibody (C-term) (MBS9209911)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse adrenal glands followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Fgfr1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Fgfr1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Fgfr1. It may not necessarily be applicable to this product.
 NCBI GI #    120952698
 NCBI GeneID    14182
 NCBI Accession #    NP_001073377.1 [Other Products]
 NCBI Related Accession #    NP_001073378.1; NP_034336.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079908.2 [Other Products]
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 UniProt Primary Accession #    P16092 [Other Products]
 UniProt Secondary Accession #    Q01736; Q60830; Q61562; Q80T10; Q8CFK8; Q9QZM7; E9Q2P4 [Other Products]
 UniProt Related Accession #    P16092 [Other Products]
 Molecular Weight    91981
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 NCBI Official Full Name    fibroblast growth factor receptor 1 isoform 2
 NCBI Official Synonym Full Names    fibroblast growth factor receptor 1
 NCBI Official Symbol    Fgfr1 [Similar Products]
 NCBI Official Synonym Symbols   
FLG; MFR; Eask; Hspy; Flt-2; c-fgr; Fgfr-1; AW208770; bFGF-R-1
[Similar Products]
 NCBI Protein Information    fibroblast growth factor receptor 1
 UniProt Protein Name    Fibroblast growth factor receptor 1
 UniProt Synonym Protein Names   
Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD_antigen: CD331
 Protein Family    FGFR1 oncogene partner
 UniProt Gene Name    Fgfr1 [Similar Products]
 UniProt Synonym Gene Names    Flg; FGFR-1; bFGF-R-1 [Similar Products]
 UniProt Entry Name    FGFR1_MOUSE
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 UniProt Comments for Fgfr1    FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; FGFR family

Cellular Component: membrane; cytoplasm; integral to membrane; plasma membrane; cytoplasmic vesicle; nucleus; receptor complex

Molecular Function: heparin binding; transferase activity; protein binding; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity

Biological Process: paraxial mesoderm development; peptidyl-tyrosine phosphorylation; cell maturation; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; orbitofrontal cortex development; protein amino acid phosphorylation; sensory perception of sound; ureteric bud development; induction of an organ; positive regulation of mesenchymal cell proliferation; midbrain development; positive regulation of cell proliferation; salivary gland morphogenesis; chondrocyte differentiation; angiogenesis; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; inner ear morphogenesis; fibroblast growth factor receptor signaling pathway; in utero embryonic development; outer ear morphogenesis; positive regulation of cell cycle; regulation of cell proliferation; neuroblast division in the ventricular zone; mesenchymal cell differentiation; generation of neurons; regulation of gene expression; auditory receptor cell development; blood vessel morphogenesis; brain development; phosphorylation; regulation of lateral mesodermal cell fate specification; lung development
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Product References and Citations for anti-Fgfr1 antibody

   Drogat, B., et al. Blood 116(12):2141-2151(2010)
Bowles, J., et al. Dev. Cell 19(3):440-449(2010)
Chung, W.C., et al. J. Neuroendocrinol. 22(8):944-950(2010)
Pond, A.C., et al. Cancer Res. 70(12):4868-4879(2010)
Maruyama, T., et al. Sci Signal 3 (123), RA40 (2010) :
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 Research Articles on Fgfr1    1. Endothelial cell-specific deletion of Fgfr1 enhanced endothelial-to-mesenchymal transition in knockout mice. FGFR1 is the key regulator of TGFbeta signaling and EndMT development.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Fgfr1 antibodyPathways associated with anti-Fgfr1 antibody
 Reference Product  PubMed Publications
 Fgf2 antibody  >727 publications with Fgfr1 and Fgf2
 Fgf1 antibody  >222 publications with Fgfr1 and Fgf1
 Fgf8 antibody  >117 publications with Fgfr1 and Fgf8
 Fgf7 antibody  >62 publications with Fgfr1 and Fgf7
 Fgf23 antibody  >52 publications with Fgfr1 and Fgf23
 Frs2 antibody  >46 publications with Fgfr1 and Frs2
 Fgf4 antibody  >39 publications with Fgfr1 and Fgf4
 Fgf9 antibody  >38 publications with Fgfr1 and Fgf9
 Fgf6 antibody  >12 publications with Fgfr1 and Fgf6
 Plcg1 antibody  >2 publications with Fgfr1 and Plcg1
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Diseases associated with anti-Fgfr1 antibodyOrgans/Tissues associated with anti-Fgfr1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >143 publications with Fgfr1 and Nervous System Diseases
 Myeloproliferative Disorders Antibodies  >139 publications with Fgfr1 and Myeloproliferative Disorders
 Disease Models, Animal Antibodies  >136 publications with Fgfr1 and Disease Models, Animal
 Craniofacial Abnormalities Antibodies  >132 publications with Fgfr1 and Craniofacial Abnormalities
 Kallmann Syndrome Antibodies  >129 publications with Fgfr1 and Kallmann Syndrome
 Breast Neoplasms Antibodies  >113 publications with Fgfr1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >96 publications with Fgfr1 and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >77 publications with Fgfr1 and Carcinoma, Squamous Cell
 TRIGONOCEPHALY 1 Antibodies  >69 publications with Fgfr1 and TRIGONOCEPHALY 1
 Small Cell Lung Carcinoma Antibodies  >63 publications with Fgfr1 and Small Cell Lung Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >340 publications with Fgfr1 and Brain
 Bone Antibodies  >326 publications with Fgfr1 and Bone
 Embryonic Tissue Antibodies  >226 publications with Fgfr1 and Embryonic Tissue
 Muscle Antibodies  >214 publications with Fgfr1 and Muscle
 Lung Antibodies  >186 publications with Fgfr1 and Lung
 Kidney Antibodies  >104 publications with Fgfr1 and Kidney
 Bone Marrow Antibodies  >102 publications with Fgfr1 and Bone Marrow
 Connective Tissue Antibodies  >91 publications with Fgfr1 and Connective Tissue
 Eye Antibodies  >87 publications with Fgfr1 and Eye
 Heart Antibodies  >85 publications with Fgfr1 and Heart
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