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anti-FBN1 antibody :: Fibrillin 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS8242354
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibrillin 1 (FBN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Fibrillin 1 Antibody

 Product Synonym Names    FBN; Fibrillin-1
 Product Gene Name   

anti-FBN1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Fibrillin 1 peptide (MBS8243440) is used for blocking the activity of Fibrillin 1 antibody (MBS8242354)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102370
 3D Structure    ModBase 3D Structure for P35555
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 Clonality    Polyclonal
 Species Reactivity    Human, Mouse, Rat, Bovine, Pig
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 Specificity    Recognizes endogenous levels of Fibrillin 1 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
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 Source    Rabbit
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Fibrillin 1. The exact sequence is proprietary.
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 Preparation and Storage    Shipped and store at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles
 Other Notes    Small volumes of anti-FBN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FBN1 antibody

   Rabbit polyclonal antibody to Fibrillin 1
 Applications Tested/Suitable for anti-FBN1 antibody   

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-FBN1 antibody    Western Blot: (1/500 - 1/1000); Immunofluorescence/Immunocytochemistry: (1/100 - 1/500)
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 Western Blot (WB) of anti-FBN1 antibody    Western blot analysis of Fibrillin 1 expression in Jurkat (A), NIH3T3 (B) whole cell lysates.
anti-FBN1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-FBN1 antibody    Immunofluorescent analysis of Fibrillin 1 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-FBN1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for FBN1. It may not necessarily be applicable to this product.
 NCBI GI #    311033452
 NCBI GeneID    2200
 NCBI Accession #    P35555.3 [Other Products]
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 UniProt Primary Accession #    P35555 [Other Products]
 UniProt Secondary Accession #    Q15972; Q75N87; B2RUU0; D2JYH6 [Other Products]
 UniProt Related Accession #    P35555 [Other Products]
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 NCBI Official Full Name    Fibrillin-1
 NCBI Official Synonym Full Names    fibrillin 1
 NCBI Official Symbol    FBN1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    fibrillin-1
 UniProt Protein Name    Fibrillin-1
 Protein Family    Fibrillin
 UniProt Gene Name    FBN1 [Similar Products]
 UniProt Synonym Gene Names    FBN [Similar Products]
 UniProt Entry Name    FBN1_HUMAN
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 NCBI Summary for FBN1    This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate a mature extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, and Shprintzen-Goldberg syndrome. [provided by RefSeq, Oct 2015]
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 UniProt Comments for FBN1    FBN1: a large, extracellular matrix glycoprotein of the fibrillin family that serves as a structural component of 10-12 nm calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support in elastic and nonelastic connective tissue throughout the body. May regulate osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Defects in this protein are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome. Interacts with COL16A1.

Protein type: Secreted, signal peptide; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 15q21.1

Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; microfibril; proteinaceous extracellular matrix

Molecular Function: calcium ion binding; extracellular matrix constituent conferring elasticity; extracellular matrix structural constituent; integrin binding; protein binding; protein complex binding

Biological Process: camera-type eye development; embryonic eye morphogenesis; extracellular matrix disassembly; extracellular matrix organization and biogenesis; heart development; metanephros development; post-embryonic eye morphogenesis; skeletal development

Disease: Acromicric Dysplasia; Ectopia Lentis 1, Isolated, Autosomal Dominant; Geleophysic Dysplasia 2; Marfan Syndrome; Mass Syndrome; Stiff Skin Syndrome; Weill-marchesani Syndrome 2
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 Research Articles on FBN1    1. Left ventricular systolic dysfunction in asymptomatic Marfan syndrome patients is related to the severity of the FBN1 gene mutation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FBN1 antibodyPathways associated with anti-FBN1 antibody
 Reference Product  PubMed Publications
 FBN2 antibody  >102 publications with FBN1 and FBN2
 FBLN5 antibody  >18 publications with FBN1 and FBLN5
 ADAMTS10 antibody  >16 publications with FBN1 and ADAMTS10
 FURIN antibody  >14 publications with FBN1 and FURIN
 DCN antibody  >8 publications with FBN1 and DCN
 VCAN antibody  >6 publications with FBN1 and VCAN
 HSPG2 antibody  >3 publications with FBN1 and HSPG2
 MFAP5 antibody  >2 publications with FBN1 and MFAP5
 ITGB6 antibody  >1 publications with FBN1 and ITGB6
 MFAP2 antibody  >1 publications with FBN1 and MFAP2
 Products by Pathway  Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
Diseases associated with anti-FBN1 antibodyOrgans/Tissues associated with anti-FBN1 antibody
 Disease Name  Pubmed Publications
 Marfan Syndrome Antibodies  >525 publications with FBN1 and Marfan Syndrome
 Cardiovascular Diseases Antibodies  >460 publications with FBN1 and Cardiovascular Diseases
 Ectopia Lentis Antibodies  >102 publications with FBN1 and Ectopia Lentis
 Aortic Aneurysm, Thoracic Antibodies  >74 publications with FBN1 and Aortic Aneurysm, Thoracic
 Disease Models, Animal Antibodies  >51 publications with FBN1 and Disease Models, Animal
 Arachnodactyly Antibodies  >41 publications with FBN1 and Arachnodactyly
 Aortic Rupture Antibodies  >27 publications with FBN1 and Aortic Rupture
 Weill-Marchesani Syndrome Antibodies  >20 publications with FBN1 and Weill-Marchesani Syndrome
 Fibrosis Antibodies  >12 publications with FBN1 and Fibrosis
 Hypertension Antibodies  >11 publications with FBN1 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >235 publications with FBN1 and Connective Tissue
 Vascular Antibodies  >111 publications with FBN1 and Vascular
 Heart Antibodies  >77 publications with FBN1 and Heart
 Skin Antibodies  >70 publications with FBN1 and Skin
 Eye Antibodies  >52 publications with FBN1 and Eye
 Bone Antibodies  >48 publications with FBN1 and Bone
 Muscle Antibodies  >47 publications with FBN1 and Muscle
 Lung Antibodies  >23 publications with FBN1 and Lung
 Embryonic Tissue Antibodies  >15 publications with FBN1 and Embryonic Tissue
 Kidney Antibodies  >10 publications with FBN1 and Kidney
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