P02676.2
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
53,340 Da
NCBI Official Full Name
Fibrinogen beta chain
NCBI Official Synonym Full Names
fibrinogen beta chain
NCBI Protein Information
fibrinogen beta chain
UniProt Protein Name
Fibrinogen beta chain
UniProt Comments for FGb
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
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Pathways associated with anti-FGb antibody
Organs/Tissues associated with anti-FGb antibody
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