EAX11354.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,954 Da
NCBI Official Full Name
fibroblast activation protein, alpha, isoform CRA_b
NCBI Official Synonym Full Names
fibroblast activation protein alpha
NCBI Protein Information
prolyl endopeptidase FAP
UniProt Protein Name
Prolyl endopeptidase FAP
UniProt Synonym Protein Names
170 kDa melanoma membrane-bound gelatinase
UniProt Synonym Gene Names
NCBI Summary for FAPa
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
UniProt Comments for FAPa
FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.14.5; EC 3.4.21.26; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 2q24.2
Cellular Component: cell surface; extracellular space; focal adhesion; lamellipodium; plasma membrane
Molecular Function: dipeptidyl-peptidase activity; endopeptidase activity; integrin binding; metalloendopeptidase activity; peptidase activity; protease binding; protein binding; protein homodimerization activity; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process: endothelial cell migration; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of fibrinolysis
Research Articles on FAPa
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Products associated with anti-FAPa antibody
Diseases associated with anti-FAPa antibody
Organs/Tissues associated with anti-FAPa antibody
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