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anti-FGF2 antibody :: Rabbit Fibroblast growth factor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1490134
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibroblast growth factor 2 (FGF2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Fibroblast growth factor 2 polyclonal Antibody

 Product Synonym Names    FGFB; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2; FGF-2
 Product Gene Name   

anti-FGF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    134920
 3D Structure    ModBase 3D Structure for P09038
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse. Other species are not tested. Please decide the specificity by homology
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Fibroblast growth factor 2 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1360 / sc-1390 / sc-79 / sc-7911
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-FGF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FGF2 antibody

   Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.
 Applications Tested/Suitable for anti-FGF2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-FGF2 antibody    All lanes: Fibroblast growth factor 2 antibody at 2ug/ml
Lane 1:mouse kidney tissue
Lane 2:mouse brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 31,23,18,22 kDa
Observed band size: 31 kDa

anti-FGF2 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-FGF2 antibody    Western blot
All lanes: FGF2 antibody at 4 ug/ml
Lane 1: HepG-2 whole cell lysate
Lane 2: Mouse heart tissue
Lane 3: Mouse liver tissue
Lane 4: Mouse lung tissue
Lane 5: Mouse kidney tissue
Lane 6: Mouse brain tissue
Lane 7: Mouse thymus tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 31,23,18,22 kDa
Observed band size: 30 kDa

anti-FGF2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FGF2 antibody    Immunohistochemistry of paraffin-embedded human prostate using MBS1490134 at dilution of 1:100
anti-FGF2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FGF2 antibody    Immunohistochemistry of paraffin-embedded mouse lung using MBS1490134 at dilution 1:100.
anti-FGF2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FGF2. It may not necessarily be applicable to this product.
 NCBI GI #    153285461
 NCBI GeneID    2247
 NCBI Accession #    NP_001997.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_002006.4 [Other Products]
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 UniProt Primary Accession #    P09038 [Other Products]
 UniProt Secondary Accession #    O00527; P78443; Q16443; Q5PY50; Q7KZ11; Q7KZ72; Q9UC54; Q9UCS5; Q9UCS6; A4LBB8 [Other Products]
 UniProt Related Accession #    P09038 [Other Products]
 Molecular Weight    21,203 Da
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 NCBI Official Full Name    fibroblast growth factor 2
 NCBI Official Synonym Full Names    fibroblast growth factor 2
 NCBI Official Symbol    FGF2 [Similar Products]
 NCBI Official Synonym Symbols   
BFGF; FGFB; FGF-2; HBGF-2
[Similar Products]
 NCBI Protein Information    fibroblast growth factor 2
 UniProt Protein Name    Fibroblast growth factor 2
 UniProt Synonym Protein Names   
Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
 Protein Family    Fibroblast growth factor
 UniProt Gene Name    FGF2 [Similar Products]
 UniProt Synonym Gene Names    FGFB; FGF-2; bFGF; HBGF-2 [Similar Products]
 UniProt Entry Name    FGF2_HUMAN
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 NCBI Summary for FGF2    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FGF2    FGF2: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation.

Protein type: Motility/polarity/chemotaxis; Activator

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: extracellular region; extracellular space; nucleus

Molecular Function: chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding

Biological Process: activation of MAPK activity; activation of MAPKK activity; axon guidance; cell migration during sprouting angiogenesis; chemotaxis; embryonic morphogenesis; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; growth factor dependent regulation of satellite cell proliferation; hyaluronan catabolic process; innate immune response; inositol phosphate biosynthetic process; insulin receptor signaling pathway; MAPKKK cascade; negative regulation of blood vessel endothelial cell migration; nerve growth factor receptor signaling pathway; nervous system development; organ morphogenesis; phosphatidylinositol biosynthetic process; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cardiac muscle cell proliferation; positive regulation of cell division; positive regulation of cell fate specification; positive regulation of cell proliferation; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; Ras protein signal transduction; regulation of angiogenesis; release of sequestered calcium ion into cytosol; signal transduction; small GTPase mediated signal transduction; somatic stem cell maintenance; ureteric bud branching; vascular endothelial growth factor receptor signaling pathway; wound healing
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 Research Articles on FGF2    1. The data suggest that breath condensate of patients with pulmonary hypertension is characterized by increased levels of the angiogenic factors angiogenin, VEGF and bFGF as well as TNF-alpha, but not IL-8.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FGF2 antibodyPathways associated with anti-FGF2 antibody
 Reference Product  PubMed Publications
 FGFR1 antibody  >750 publications with FGF2 and FGFR1
 FGFR2 antibody  >369 publications with FGF2 and FGFR2
 FGFR3 antibody  >141 publications with FGF2 and FGFR3
 FGFR4 antibody  >71 publications with FGF2 and FGFR4
 NANOG antibody  >62 publications with FGF2 and NANOG
 SDC1 antibody  >54 publications with FGF2 and SDC1
 SDC4 antibody  >34 publications with FGF2 and SDC4
 SDC2 antibody  >12 publications with FGF2 and SDC2
 HSPG2 antibody  >7 publications with FGF2 and HSPG2
 GPC1 antibody  >4 publications with FGF2 and GPC1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Constitutive Signaling By Aberrant PI3K In Cancer Pathway antibodies  Constitutive Signaling By Aberrant PI3K In Cancer Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
Diseases associated with anti-FGF2 antibodyOrgans/Tissues associated with anti-FGF2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1080 publications with FGF2 and Nervous System Diseases
 Necrosis Antibodies  >635 publications with FGF2 and Necrosis
 Wounds and Injuries Antibodies  >604 publications with FGF2 and Wounds and Injuries
 Inflammation Antibodies  >473 publications with FGF2 and Inflammation
 Heart Diseases Antibodies  >430 publications with FGF2 and Heart Diseases
 Disease Progression Antibodies  >357 publications with FGF2 and Disease Progression
 Myocardial Ischemia Antibodies  >354 publications with FGF2 and Myocardial Ischemia
 Lung Diseases Antibodies  >348 publications with FGF2 and Lung Diseases
 Hyperplasia Antibodies  >263 publications with FGF2 and Hyperplasia
 Lung Neoplasms Antibodies  >238 publications with FGF2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >4852 publications with FGF2 and Vascular
 Brain Antibodies  >2241 publications with FGF2 and Brain
 Bone Antibodies  >1931 publications with FGF2 and Bone
 Muscle Antibodies  >1840 publications with FGF2 and Muscle
 Embryonic Tissue Antibodies  >1300 publications with FGF2 and Embryonic Tissue
 Eye Antibodies  >1047 publications with FGF2 and Eye
 Skin Antibodies  >844 publications with FGF2 and Skin
 Connective Tissue Antibodies  >754 publications with FGF2 and Connective Tissue
 Bone Marrow Antibodies  >689 publications with FGF2 and Bone Marrow
 Heart Antibodies  >675 publications with FGF2 and Heart
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