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anti-FN antibody :: Rabbit anti-Rat Fibronectin (FN) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004823 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
1 mg  /  $785 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Fibronectin (FN), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Fibronectin (FN)

 Product Gene Name   

anti-FN antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
Biotin Conjugated Antibody: Fibronectin (FN) (MBS2006229)
 Matching Pairs    Antibody: Fibronectin (FN) (MBS2004823)
Antigen: Fibronectin (FN) (MBS2011508)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
FITC Conjugated Antibody: Fibronectin (FN) (MBS2015000)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
APC: Fibronectin (FN) (MBS2035702)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
PE Conjugated Antibody: Fibronectin (FN) (MBS2035703)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
APC: Fibronectin (FN) (MBS2035704)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
Cy3 Conjugated Antibody: Fibronectin (FN) (MBS2035705)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
HRP Conjugated Antibody: Fibronectin (FN) (MBS2035706)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
APC: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Fibronectin (FN) (MBS2004823)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG S- SNGEPC VLPFHYNGRT FYSCTTEGRQ DGHLWCSTTS NYEQDQKYSF CTDHAVLVQT RGGNSNGALC HFPFLYSNRN YSDCTSEGRR DNMKWCGTTQ NYDADQKFGF CPMAAHEEIC TTNEGVMYRI GDQWDKQHDL GHMMRCTCVG NGRGQWACIP YSQLRDQCIV DDITYNVNDT FHKRHEEGHM LNCTCFGQGR GRWKCDPI
 3D Structure    ModBase 3D Structure for P04937
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    The antibody is a rabbit polyclonal antibody raised against FN. It has been selected for its ability to recognize FN in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    FN, Rat
 Immunogen Information    Recombinant FN (Ser355~Ile558) with N-terminal His-Tag expressed in E.coli.
 Accession No.    RPA037Ra01
 UOM    100ug
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2035704
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-FN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FN antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FN antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-FN antibody    (Figure. Western Blot; Sample: Recombinant Fibronectin, Rat.)
anti-FN antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FN antibody    (Figure. DAB staining on IHC-P; Samples: Rat Testis Tissue.)
anti-FN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FN antibody    (Figure. DAB staining on IHC-P; Samples: Rat Kidney Tissue.)
anti-FN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FN antibody    (Figure. DAB staining on IHC-P; Samples: Rat Heart Tissue.)
anti-FN antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-FN antibody    (Figure. DAB staining on IHC-P; Samples: Rat Liver Tissue.)
anti-FN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FN. It may not necessarily be applicable to this product.
 NCBI GI #    120178
 NCBI GeneID    25661
 NCBI Accession #    P04937.2 [Other Products]
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 UniProt Primary Accession #    P04937 [Other Products]
 UniProt Secondary Accession #    Q6LDX9 [Other Products]
 UniProt Related Accession #    P04937 [Other Products]
 Molecular Weight    259,350 Da
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 NCBI Official Full Name    Fibronectin
 NCBI Official Synonym Full Names    fibronectin 1
 NCBI Official Symbol    Fn1 [Similar Products]
 NCBI Official Synonym Symbols   
fn-1; FIBNEC
[Similar Products]
 NCBI Protein Information    fibronectin
 UniProt Protein Name    Fibronectin
 Protein Family    Fibronectin
 UniProt Gene Name    Fn1 [Similar Products]
 UniProt Synonym Gene Names    FN [Similar Products]
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 NCBI Summary for FN    extracellular matrix component; may play a role in fibrosis and tumor metastasis [RGD, Feb 2006]
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 UniProt Comments for FN    FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: apical plasma membrane; basal lamina; basement membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular matrix; extracellular region; extracellular space; fibrinogen complex; proteinaceous extracellular matrix

Molecular Function: chaperone binding; enzyme binding; extracellular matrix structural constituent; heparin binding; identical protein binding; integrin binding; mercury ion binding; protease activator activity; protease binding; protein binding; protein C-terminus binding; receptor binding

Biological Process: acute-phase response; angiogenesis; calcium-independent cell-matrix adhesion; cell activation; cell adhesion; cell-matrix adhesion; cell-substrate junction assembly; extracellular matrix organization; glial cell migration; integrin activation; interaction with other organism via secreted substance during symbiotic interaction; interaction with symbiont; negative regulation of apoptosis; ossification; peptide cross-linking; positive regulation of axon extension; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of fibroblast proliferation; regulation of cell shape; regulation of protein amino acid phosphorylation; response to activity; response to drug; response to glucocorticoid stimulus; response to iron ion; response to ozone; response to wounding; wound healing
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 Research Articles on FN    1. PTH pretreatment prevented TGF-beta1 and high glucose-induced Smad2/3 phosphorylation and consequent upregulation of fibronectin and type IV collagen within 4 h.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-FN antibodyOrgans/Tissues associated with anti-FN antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Fibronectin Matrix Formation Pathway antibodies  Fibronectin Matrix Formation Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >27 publications with FN and Lung
 Muscle Antibodies  >24 publications with FN and Muscle
 Kidney Antibodies  >24 publications with FN and Kidney
 Liver Antibodies  >22 publications with FN and Liver
 Embryonic Tissue Antibodies  >19 publications with FN and Embryonic Tissue
 Brain Antibodies  >17 publications with FN and Brain
 Connective Tissue Antibodies  >15 publications with FN and Connective Tissue
 Colon Antibodies  >9 publications with FN and Colon
 Heart Antibodies  >8 publications with FN and Heart
 Prostate Antibodies  >7 publications with FN and Prostate
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