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anti-FCN1 antibody :: Rabbit anti-Human Ficolin 1 (FCN1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2017851 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-FCN1 antibody
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Ficolin 1 (FCN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

FITC-linked Antibody to Ficolin 1 (FCN1)

 Product Gene Name   

anti-FCN1 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Ficolin 1 (FCN1) (MBS2015772)
FITC Conjugated Antibody: Ficolin 1 (FCN1) (MBS2017851)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (137797711..137809849, complement). Location: 9q34
 OMIM    601252
 3D Structure    ModBase 3D Structure for O00602
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Supplied as solution from in PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol
 Concentration    200ug/ml (lot specific)
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 Source    Antibody labeling
 Label    FITC
 Traits    Liquid
 Immunogen    Recombinant FCN1 (Asp45~Thr249) expressed in E.coli
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 Preparation and Storage    Storage: Avoid reapeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined accelerated thermal degredation test, that is, incubate the protein at 37C for 48h, and no obvious degredation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition
Note: As fluorescence can photobleach when exposed to light, therefore the antibody must be protected from light.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-FCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-FCN1 antibody    FITC Antibody
 Applications Tested/Suitable for anti-FCN1 antibody   

WB; IHC; ICC; IF

 Application Notes for anti-FCN1 antibody    Western Blotting: 0.5-2 ug/ml
Immunohistochemistry: 5-20 ug/ml
Immunocytochemistry: 5-20 ug/ml
Optimal working dilutions must be determined by end user.
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NCBI/Uniprot data below describe general gene information for FCN1. It may not necessarily be applicable to this product.
 NCBI GI #    8051584
 NCBI GeneID    2219
 NCBI Accession #    NP_001994.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002003.3 [Other Products]
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 UniProt Primary Accession #    O00602 [Other Products]
 UniProt Secondary Accession #    Q5VYV5; Q92596 [Other Products]
 UniProt Related Accession #    O00602 [Other Products]
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 NCBI Official Full Name    ficolin-1
 NCBI Official Synonym Full Names    ficolin (collagen/fibrinogen domain containing) 1
 NCBI Official Symbol    FCN1 [Similar Products]
 NCBI Official Synonym Symbols   
FCNM
[Similar Products]
 NCBI Protein Information    ficolin-1; M-ficolin; ficolin-A; ficolin-alpha; collagen/fibrinogen domain-containing protein 1; ficolin (collagen/fibrinogen domain-containing) 1
 UniProt Protein Name    Ficolin-1
 UniProt Synonym Protein Names   
Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin
 Protein Family    Ficolin
 UniProt Gene Name    FCN1 [Similar Products]
 UniProt Synonym Gene Names    FCNM [Similar Products]
 UniProt Entry Name    FCN1_HUMAN
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 NCBI Summary for FCN1    The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FCN1    FCN1: Complement-activating lectin and pattern recognition receptor. Binds GlcNAc. Binds preferentially to 9-O-acetylated 2- 6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. Belongs to the ficolin lectin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: collagen; extrinsic to external side of plasma membrane; extracellular region

Molecular Function: protein binding; G-protein-coupled receptor binding; metal ion binding; carbohydrate binding; pattern recognition receptor activity; sialic acid binding

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of virion penetration into host cell; cell surface pattern recognition receptor signaling pathway; innate immune response; complement activation, lectin pathway; recognition of apoptotic cell; complement activation
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 Research Articles on FCN1    1. Data show that a photodynamic therapy (PDT) dose-dependent upregulation of CRP gene, as well as of PTX3 and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K/Akt/AP-1 pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FCN1 antibodyPathways associated with anti-FCN1 antibody
 Reference Product  PubMed Publications
 MASP1 antibody  >2 publications with FCN1 and MASP1
 CD14 antibody  >1 publications with FCN1 and CD14
 Products by Pathway  Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies  Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Lectin Pathway Of Complement Activation antibodies  Lectin Pathway Of Complement Activation Diagram
Diseases associated with anti-FCN1 antibodyOrgans/Tissues associated with anti-FCN1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with FCN1 and Inflammation
 Inflammatory Bowel Diseases Antibodies  >1 publications with FCN1 and Inflammatory Bowel Diseases
 Gastrointestinal Diseases Antibodies  >1 publications with FCN1 and Gastrointestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with FCN1 and Blood
 Bone Antibodies  >1 publications with FCN1 and Bone
 Brain Antibodies  >1 publications with FCN1 and Brain
 Bone Marrow Antibodies  >1 publications with FCN1 and Bone Marrow
 Intestine Antibodies  >1 publications with FCN1 and Intestine
 Lung Antibodies  >1 publications with FCN1 and Lung
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