AAW56076.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,813 Da
NCBI Official Full Name
flavin containing monooxygenase 1
NCBI Official Synonym Full Names
flavin containing monooxygenase 1
NCBI Protein Information
dimethylaniline monooxygenase [N-oxide-forming] 1
UniProt Protein Name
Dimethylaniline monooxygenase [N-oxide-forming] 1
UniProt Synonym Protein Names
Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; FMO 1
UniProt Synonym Gene Names
NCBI Summary for FMO1
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for FMO1
FMO1: This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines. Belongs to the FMO family.
Protein type: EC 1.14.13.8; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: 1q24.3
Cellular Component: endoplasmic reticulum lumen
Molecular Function: flavin-containing monooxygenase activity; monooxygenase activity
Biological Process: organic acid metabolic process; toxin metabolic process; xenobiotic metabolic process
Research Articles on FMO1
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Products associated with anti-FMO1 antibody
Pathways associated with anti-FMO1 antibody
Diseases associated with anti-FMO1 antibody
Organs/Tissues associated with anti-FMO1 antibody
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