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anti-FSHR antibody :: Rabbit anti-Human Follicle Stimulating Hormone Receptor (FSHR) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2001444 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $235 +1 FREE 8GB USB
0.1 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Follicle Stimulating Hormone Receptor (FSHR), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Follicle Stimulating Hormone Receptor (FSHR)

 Product Gene Name   

anti-FSHR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-CHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INP
 Chromosome Location    Chromosome: 2; NC_000002.11 (49189296..49381666, complement). Location: 2p21-p16
 OMIM    136435
 3D Structure    ModBase 3D Structure for P23945
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against FSHR. It has been selected for its ability to recognize FSHR in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant FSHR (Cys18~Pro113) expressed in E.coli.
 Quality Control    Content: The quality control contains recombinant MUC5B (Lys5366~Val5444) disposed in loading buffer.
Usage: 10uL per well when 3,3'-Diaminobenzidine(DAB) as the substrate.
                5uL per well when used in enhanced chemilumescent (ECL).
Note: The quality control is specifically manufactured as the positive control.Not used for other purposes.
Loading Buffer: 100mM Tris(pH8.8), 2% SDS, 200mM NaCl, 50% glycerol,BPB 0.01%, NaN3 0.02%.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-FSHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-FSHR antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-FSHR antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-FSHR antibody    anti-FSHR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for FSHR. It may not necessarily be applicable to this product.
 NCBI GI #    300073
 NCBI GeneID    2492
 NCBI Accession #    AAB26480.1 [Other Products]
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 UniProt Primary Accession #    P23945 [Other Products]
 UniProt Secondary Accession #    Q05AH0; Q16225; Q4QRJ3; Q4ZFZ2; Q53RW2; A8K947; G5CBS7; G5E967; J3KQ00 [Other Products]
 UniProt Related Accession #    P23945 [Other Products]
 Molecular Weight    78,265 Da
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 NCBI Official Full Name    follicle stimulating hormone receptor
 NCBI Official Synonym Full Names    follicle stimulating hormone receptor
 NCBI Official Symbol    FSHR [Similar Products]
 NCBI Official Synonym Symbols   
LGR1; ODG1; FSHRO
[Similar Products]
 NCBI Protein Information    follicle-stimulating hormone receptor; FSH receptor; follitropin receptor
 UniProt Protein Name    Follicle-stimulating hormone receptor
 UniProt Synonym Protein Names   
Follitropin receptor
 Protein Family    Follicle-stimulating hormone receptor
 UniProt Gene Name    FSHR [Similar Products]
 UniProt Synonym Gene Names    LGR1; FSH-R [Similar Products]
 UniProt Entry Name    FSHR_HUMAN
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 NCBI Summary for FSHR    The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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 UniProt Comments for FSHR    FSHR: Receptor for follicle-stimulating hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Defects in FSHR are a cause of ovarian dysgenesis type 1 (ODG1); also known as premature ovarian failure or gonadal dysgenesis XX type or XX gonadal dysgenesis (XXGD) or hereditary hypergonadotropic ovarian failure or hypergonadotropic ovarian dysgenesis with normal karyotype. ODG1 is an autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Defects in FSHR are a cause of ovarian hyperstimulation syndrome (OHSS). OHSS is a disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p21-p16

Cellular Component: plasma membrane; integral to membrane

Molecular Function: protein binding; follicle-stimulating hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; follicle-stimulating hormone signaling pathway; gonad development; male gonad development; female gamete generation; spermatogenesis; female gonad development

Disease: Ovarian Hyperstimulation Syndrome; Twinning, Dizygotic; Ovarian Dysgenesis 1
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 Research Articles on FSHR    1. Serum FSH levels are affected by the combination of genetic polymorphisms in FSHR and FSHB
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FSHR antibodyPathways associated with anti-FSHR antibody
 Reference Product  PubMed Publications
 FSHB antibody  >20 publications with FSHR and FSHB
 GDF9 antibody  >7 publications with FSHR and GDF9
 CGA antibody  >5 publications with FSHR and CGA
 APPL1 antibody  >4 publications with FSHR and APPL1
 POMC antibody  >2 publications with FSHR and POMC
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-FSHR antibodyOrgans/Tissues associated with anti-FSHR antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >68 publications with FSHR and Neoplasms
 Infertility, Female Antibodies  >64 publications with FSHR and Infertility, Female
 Infertility, Male Antibodies  >48 publications with FSHR and Infertility, Male
 Genital Diseases, Male Antibodies  >42 publications with FSHR and Genital Diseases, Male
 Polycystic Ovary Syndrome Antibodies  >31 publications with FSHR and Polycystic Ovary Syndrome
 Ovarian Neoplasms Antibodies  >29 publications with FSHR and Ovarian Neoplasms
 Ovarian Hyperstimulation Syndrome Antibodies  >28 publications with FSHR and Ovarian Hyperstimulation Syndrome
 Carcinoma Antibodies  >14 publications with FSHR and Carcinoma
 Disorders of Sex Development Antibodies  >12 publications with FSHR and Disorders of Sex Development
 Oligospermia Antibodies  >8 publications with FSHR and Oligospermia
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >127 publications with FSHR and Testis
 Mixed Antibodies  >1 publications with FSHR and Mixed
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