NP_001186276.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
47,346 Da
NCBI Official Full Name
forkhead box protein P3
NCBI Official Synonym Full Names
forkhead box P3
NCBI Protein Information
forkhead box protein P3
UniProt Protein Name
Forkhead box protein P3
UniProt Synonym Protein Names
Scurfin
NCBI Summary for FOXP3
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Comments for FOXP3
FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: X A1.1|X 3.41 cM
Cellular Component: cytoplasm; intracellular; nucleoplasm; nucleus
Molecular Function: DNA binding; DNA binding transcription factor activity; histone acetyltransferase binding; histone deacetylase binding; metal ion binding; NFAT protein binding; nucleic acid binding; protein binding; protein homodimerization activity; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Biological Process: anatomical structure morphogenesis; B cell homeostasis; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; cytokine production; inhibition of CREB transcription factor; myeloid cell homeostasis; negative regulation of cell proliferation; negative regulation of chronic inflammatory response; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone acetylation; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of inflammatory response; negative regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of interleukin-6 production; negative regulation of isotype switching to IgE isotypes; negative regulation of lymphocyte proliferation; negative regulation of NF-kappaB transcription factor activity; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of immature T cell proliferation in the thymus; positive regulation of interleukin-4 production; positive regulation of peripheral T cell tolerance induction; positive regulation of regulatory T cell differentiation; positive regulation of T cell anergy; positive regulation of T cell tolerance induction; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta1 production; regulation of immunoglobulin production; regulation of isotype switching to IgG isotypes; regulation of T cell anergy; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; regulatory T cell differentiation; T cell activation; T cell mediated immunity; T cell receptor signaling pathway; tolerance induction; tolerance induction to self antigen; transcription, DNA-dependent
Research Articles on FOXP3
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Pathways associated with anti-FOXP3 antibody
Diseases associated with anti-FOXP3 antibody
Disease Name |
Pubmed Publications |
Inflammation Antibodies |
>1962 publications with FOXP3 and Inflammation |
Disease Models, Animal Antibodies |
>1442 publications with FOXP3 and Disease Models, Animal |
Necrosis Antibodies |
>680 publications with FOXP3 and Necrosis |
Nervous System Diseases Antibodies |
>647 publications with FOXP3 and Nervous System Diseases |
Liver Diseases Antibodies |
>389 publications with FOXP3 and Liver Diseases |
Encephalomyelitis, Autoimmune, Experimental Antibodies |
>353 publications with FOXP3 and Encephalomyelitis, Autoimmune, Experimental |
Diabetes Mellitus, Type 1 Antibodies |
>332 publications with FOXP3 and Diabetes Mellitus, Type 1 |
Cardiovascular Diseases Antibodies |
>327 publications with FOXP3 and Cardiovascular Diseases |
Neoplasms, Experimental Antibodies |
>308 publications with FOXP3 and Neoplasms, Experimental |
Adenocarcinoma Antibodies |
>281 publications with FOXP3 and Adenocarcinoma |
Organs/Tissues associated with anti-FOXP3 antibody
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