NP_001166237.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,840 Da
NCBI Official Full Name
forkhead box protein P2 isoform V
NCBI Official Synonym Full Names
forkhead box P2
NCBI Protein Information
forkhead box protein P2
UniProt Protein Name
Forkhead box protein P2
UniProt Synonym Protein Names
CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
UniProt Synonym Gene Names
UniProt Entry Name
FOXP2_HUMAN
NCBI Summary for FOXP2
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
UniProt Comments for FOXP2
FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: nucleus
Molecular Function: DNA binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: alveolus development; anatomical structure morphogenesis; camera-type eye development; caudate nucleus development; cell differentiation; cerebellum development; cerebral cortex development; growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of mesenchymal cell proliferation; post-embryonic development; putamen development; righting reflex; skeletal muscle development; smooth muscle development; transcription, DNA-dependent; vocal learning
Disease: Speech-language Disorder 1
Research Articles on FOXP2
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Products associated with anti-FOXP2 antibody
Diseases associated with anti-FOXP2 antibody
Organs/Tissues associated with anti-FOXP2 antibody
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