NP_001107849.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,407 Da
NCBI Official Full Name
forkhead box protein P3 isoform b
NCBI Official Synonym Full Names
forkhead box P3
NCBI Official Synonym Symbols
JM2; AIID; IPEX; PIDX; XPID; DIETER [Similar Products]
NCBI Protein Information
forkhead box protein P3
UniProt Protein Name
Forkhead box protein P3
UniProt Synonym Protein Names
Scurfin
UniProt Synonym Gene Names
UniProt Entry Name
FOXP3_HUMAN
NCBI Summary for FOXP3
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for FOXP3
FOXP3: Probable transcription factor. Plays a critical role in the control of immune response. Interacts with IKZF3. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Cell cycle regulation; Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: cytoplasm; nucleus; protein complex
Molecular Function: histone acetyltransferase binding; histone deacetylase binding; metal ion binding; NF-kappaB binding; NFAT protein binding; protein binding; protein homodimerization activity; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: anatomical structure morphogenesis; B cell homeostasis; CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment; chromatin remodeling; cytokine production; inhibition of CREB transcription factor; inhibition of NF-kappaB transcription factor; myeloid cell homeostasis; negative regulation of activated T cell proliferation; negative regulation of cell proliferation; negative regulation of chronic inflammatory response; negative regulation of cytokine biosynthetic process; negative regulation of cytokine secretion; negative regulation of histone acetylation; negative regulation of histone deacetylation; negative regulation of immune response; negative regulation of interferon-gamma biosynthetic process; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of interleukin-17 production; negative regulation of interleukin-2 biosynthetic process; negative regulation of interleukin-2 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of interleukin-6 production; negative regulation of isotype switching to IgE isotypes; negative regulation of T cell cytokine production; negative regulation of T cell proliferation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; positive regulation of histone acetylation; positive regulation of immature T cell proliferation in the thymus; positive regulation of interleukin-4 production; positive regulation of peripheral T cell tolerance induction; positive regulation of T cell anergy; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor-beta1 production; regulation of isotype switching to IgG isotypes; regulation of T cell anergy; regulation of transcription, DNA-dependent; response to virus; T cell activation; T cell homeostasis; T cell mediated immunity; T cell receptor signaling pathway; tolerance induction to self antigen; transcription, DNA-dependent
Disease: Diabetes Mellitus, Insulin-dependent; Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-linked
Research Articles on FOXP3
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Products associated with anti-FOXP3 antibody
Pathways associated with anti-FOXP3 antibody
Diseases associated with anti-FOXP3 antibody
Disease Name |
Pubmed Publications |
Inflammation Antibodies |
>2302 publications with FOXP3 and Inflammation |
Disease Models, Animal Antibodies |
>1647 publications with FOXP3 and Disease Models, Animal |
Necrosis Antibodies |
>768 publications with FOXP3 and Necrosis |
Nervous System Diseases Antibodies |
>750 publications with FOXP3 and Nervous System Diseases |
Lung Diseases Antibodies |
>676 publications with FOXP3 and Lung Diseases |
Liver Diseases Antibodies |
>447 publications with FOXP3 and Liver Diseases |
Cardiovascular Diseases Antibodies |
>392 publications with FOXP3 and Cardiovascular Diseases |
Encephalomyelitis, Autoimmune, Experimental Antibodies |
>392 publications with FOXP3 and Encephalomyelitis, Autoimmune, Experimental |
Diabetes Mellitus, Type 1 Antibodies |
>379 publications with FOXP3 and Diabetes Mellitus, Type 1 |
Neoplasms, Experimental Antibodies |
>317 publications with FOXP3 and Neoplasms, Experimental |
Organs/Tissues associated with anti-FOXP3 antibody
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