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anti-FYN antibody :: Rabbit Fyn (Phospho-Tyr530) Polyclonal Antibody

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 Product Name   

Fyn (Phospho-Tyr530), Polyclonal Antibody

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 Also Known As   

Fyn (Phospho-Tyr530) Antibody

 Product Synonym Names    Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn; FYN
 Product Gene Name   

anti-FYN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137025
 3D Structure    ModBase 3D Structure for P06241
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Antigen Type    synthetic peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-FYN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-FYN antibody

   Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
 Product Categories/Family for anti-FYN antibody    Phospho Antibodies
 Applications Tested/Suitable for anti-FYN antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-FYN antibody    WB~~1:1000
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 Western Blot (WB) of anti-FYN antibody    Western blot analysis of extracts from LOVO cells, using Fyn (Phospho-Tyr530) antibody (#A0430).
anti-FYN antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-FYN antibody    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Fyn (Phospho-Tyr530) antibody (#A0430).
anti-FYN antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FYN. It may not necessarily be applicable to this product.
 NCBI GI #    4503823
 NCBI GeneID    2534
 NCBI Accession #    NP_002028.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002037.5 [Other Products]
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 UniProt Primary Accession #    P06241 [Other Products]
 UniProt Secondary Accession #    Q16248; Q5R3A6; Q5R3A7; Q8N5D7; B5BU57; E1P557; H0UI48 [Other Products]
 UniProt Related Accession #    P06241 [Other Products]
 Molecular Weight    60762
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 NCBI Official Full Name    tyrosine-protein kinase Fyn isoform a
 NCBI Official Synonym Full Names    FYN proto-oncogene, Src family tyrosine kinase
 NCBI Official Symbol    FYN [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Fyn
 UniProt Protein Name    Tyrosine-protein kinase Fyn
 UniProt Synonym Protein Names   
Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    FYN [Similar Products]
 UniProt Synonym Gene Names    SLK [Similar Products]
 UniProt Entry Name    FYN_HUMAN
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 NCBI Summary for FYN    This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FYN    Fyn: a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy.

Protein type: Protein kinase, TK; EC; Protein kinase, tyrosine (non-receptor); Oncoprotein; Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: extrinsic to internal side of plasma membrane; mitochondrion; postsynaptic density; plasma membrane; actin filament; nucleus; cytosol; endosome; lipid raft

Molecular Function: tubulin binding; CD8 receptor binding; ephrin receptor binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; G-protein-coupled receptor binding; peptide hormone receptor binding; protein-tyrosine kinase activity; T cell receptor binding; phosphoinositide 3-kinase binding; glycoprotein binding; CD4 receptor binding; ATP binding

Biological Process: axon guidance; central nervous system development; viral reproduction; T cell activation; nerve growth factor receptor signaling pathway; neuron migration; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of apoptosis; regulation of cell shape; calcium ion transport; forebrain development; ephrin receptor signaling pathway; feeding behavior; negative regulation of neuron apoptosis; cell differentiation; response to drug; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; dendrite morphogenesis; activated T cell proliferation; learning; regulation of defense response to virus by virus; regulation of cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; detection of mechanical stimulus involved in sensory perception of pain; response to ethanol; T cell costimulation; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; negative regulation of protein catabolic process; leukocyte migration; transmembrane receptor protein tyrosine kinase signaling pathway
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Product References and Citations for anti-FYN antibody

   Kawakami T.,et al.Mol. Cell. Biol. 6:4195-4201(1986).
Semba K.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5459-5463(1986).
Rigley K.,et al.J. Immunol. 154:1136-1145(1995).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Mungall A.J.,et al.Nature 425:805-811(2003).
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 Research Articles on FYN    1. Results indicate that FYN has an important role in tamoxifen resistance, and its subcellular localization in breast tumor cells may be an important novel biomarker of response to endocrine therapy in breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-FYN antibodyDiseases associated with anti-FYN antibody
 Reference Product  PubMed Publications
 CBL antibody  >67 publications with FYN and CBL
 FYB antibody  >48 publications with FYN and FYB
 CTNNB1 antibody  >26 publications with FYN and CTNNB1
 CD36 antibody  >24 publications with FYN and CD36
 SHC1 antibody  >15 publications with FYN and SHC1
 BCAR1 antibody  >14 publications with FYN and BCAR1
 KHDRBS1 antibody  >12 publications with FYN and KHDRBS1
 SNCA antibody  >2 publications with FYN and SNCA
 GRIN2B antibody  >1 publications with FYN and GRIN2B
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >188 publications with FYN and Nervous System Diseases
 Inflammation Antibodies  >87 publications with FYN and Inflammation
 Cell Transformation, Neoplastic Antibodies  >49 publications with FYN and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >48 publications with FYN and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >48 publications with FYN and Breast Neoplasms
 Necrosis Antibodies  >43 publications with FYN and Necrosis
 Kidney Diseases Antibodies  >30 publications with FYN and Kidney Diseases
 Lung Diseases Antibodies  >30 publications with FYN and Lung Diseases
 Neoplasm Metastasis Antibodies  >22 publications with FYN and Neoplasm Metastasis
 Heart Diseases Antibodies  >20 publications with FYN and Heart Diseases
Organs/Tissues associated with anti-FYN antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >790 publications with FYN and Blood
 Brain Antibodies  >465 publications with FYN and Brain
 Nerve Antibodies  >212 publications with FYN and Nerve
 Vascular Antibodies  >109 publications with FYN and Vascular
 Bone Antibodies  >94 publications with FYN and Bone
 Muscle Antibodies  >93 publications with FYN and Muscle
 Kidney Antibodies  >85 publications with FYN and Kidney
 Thymus Antibodies  >75 publications with FYN and Thymus
 Lung Antibodies  >66 publications with FYN and Lung
 Liver Antibodies  >55 publications with FYN and Liver
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