NP_001004056.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,216 Da
NCBI Official Full Name
G protein-coupled receptor kinase 4 isoform beta
NCBI Official Synonym Full Names
G protein-coupled receptor kinase 4
NCBI Protein Information
G protein-coupled receptor kinase 4
UniProt Protein Name
G protein-coupled receptor kinase 4
UniProt Synonym Protein Names
G protein-coupled receptor kinase GRK4; ITI1
UniProt Synonym Gene Names
NCBI Summary for GRK4
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Comments for GRK4
GRK4: Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cell cortex; cell soma; cytosol; dendrite
Molecular Function: ATP binding; G-protein coupled receptor kinase activity; rhodopsin kinase activity
Biological Process: G-protein coupled receptor internalization; protein amino acid phosphorylation; receptor internalization; regulation of G-protein coupled receptor protein signaling pathway; regulation of rhodopsin mediated signaling; signal transduction
Research Articles on GRK4
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Products associated with anti-GRK4 antibody
Pathways associated with anti-GRK4 antibody
Diseases associated with anti-GRK4 antibody
Organs/Tissues associated with anti-GRK4 antibody
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