Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TDG rightarrow Polyclonal TDG  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Fructose-bisphosphate aldolase A (ALDOA) Antibody
 • CRH cDNA Clone
 • INSR-beta ELISA Kit
 • Glargine ELISA Kit
 • SERPINE2 Antibody
 • Nucleoprotein Antibody
 • Coronin 1A (CORO1A) Antibody
 • CBFA2T2 Antibody
 • IL-13 (IL13) ELISA Kit
 • Visceral Adipose Specific Serine Protease Inhibitor (VASPIN) ELISA Kit
 • deoxypyridinoline, DPD ELISA Kit
 • MRPS9 Antibody
 • CP4-EPSPS Antibody
 • Meteorin-like protein (Metrnl) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TDG antibody :: Rabbit anti-Human, Mouse G/T mismatch-specific thymine DNA glycosylase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1498143
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G/T mismatch-specific thymine DNA glycosylase (TDG), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human G/T mismatch-specific thymine DNA glycosylase polyclonal Antibody(TDG)

 Product Synonym Names    Thymine-DNA glycosylase; hTDG; TDG
 Product Gene Name   

anti-TDG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    601423
 3D Structure    ModBase 3D Structure for Q13569
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
Section Bar
 Purity/Purification    Antigen Affinity Purified
Section Bar
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human G/T mismatch-specific thymine DNA glycosylase protein(141-410aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22845 / sc-22847 / sc-292440
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TDG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-TDG antibody

   DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
 Applications Tested/Suitable for anti-TDG antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TDG antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
Section Bar
 Western Blot (WB) of anti-TDG antibody    All lanes: G/T mismatch-specific thymine DNA glycosylase antibody at 6ug/ml+mouse brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 46kDa
Observed band size: 46kDa

anti-TDG antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-TDG antibody    Immunohistochemistry of paraffin-embedded human heart using MBS1498143 at dilution 1:100
anti-TDG antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-TDG antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS1498143 at dilution 1:100
anti-TDG antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TDG. It may not necessarily be applicable to this product.
 NCBI GI #    59853162
 NCBI GeneID    6996
 NCBI Accession #    NP_003202.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003211.4 [Other Products]
Section Bar
 UniProt Primary Accession #    Q13569 [Other Products]
 UniProt Secondary Accession #    Q8IUZ6; Q8IZM3 [Other Products]
 UniProt Related Accession #    Q13569 [Other Products]
 Molecular Weight    46,053 Da
Table BarTOPTable Bar
 NCBI Official Full Name    G/T mismatch-specific thymine DNA glycosylase
 NCBI Official Synonym Full Names    thymine DNA glycosylase
 NCBI Official Symbol    TDG [Similar Products]
 NCBI Official Synonym Symbols   
hTDG
[Similar Products]
 NCBI Protein Information    G/T mismatch-specific thymine DNA glycosylase
 UniProt Protein Name    G/T mismatch-specific thymine DNA glycosylase
 UniProt Synonym Protein Names   
Thymine-DNA glycosylase; hTDG
 Protein Family    G/T mismatch-specific thymine DNA glycosylase
 UniProt Gene Name    TDG [Similar Products]
 UniProt Synonym Gene Names    hTDG [Similar Products]
 UniProt Entry Name    TDG_HUMAN
Section Bar
 NCBI Summary for TDG    The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for TDG    TDG: In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar- phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. Belongs to the TDG/mug DNA glycosylase family.

Protein type: EC 3.2.2.29; Hydrolase; DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q24.1

Cellular Component: nucleoplasm; nucleus; plasma membrane; PML body

Molecular Function: damaged DNA binding; DNA N-glycosylase activity; double-stranded DNA binding; mismatched DNA binding; protein binding; protein homodimerization activity; protein kinase C binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; structure-specific DNA binding; SUMO binding; uracil DNA N-glycosylase activity

Biological Process: base-excision repair; base-excision repair, AP site formation; cellular protein metabolic process; chromatin modification; depyrimidination; DNA repair; embryonic development; gene expression; mismatch repair; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; post-translational protein modification; protein sumoylation; regulation of gene expression, epigenetic; transcription, DNA-dependent
Table BarTOPTable Bar
 Research Articles on TDG    1. these results suggest that individuals harboring the G199S in Thymine DNA glycosylase variant may have increased risk for developing cancer.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TDG antibodyPathways associated with anti-TDG antibody
 Reference Product  PubMed Publications
 SUMO1 antibody  >10 publications with TDG and SUMO1
 LGALS1 antibody  >9 publications with TDG and LGALS1
 PML antibody  >3 publications with TDG and PML
 XPC antibody  >3 publications with TDG and XPC
 SUMO3 antibody  >2 publications with TDG and SUMO3
 SUMO2 antibody  >2 publications with TDG and SUMO2
 CREBBP antibody  >1 publications with TDG and CREBBP
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Cleavage Of The Damaged Pyrimidine Pathway antibodies  Cleavage Of The Damaged Pyrimidine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depyrimidination Pathway antibodies  Depyrimidination Pathway Diagram
 Displacement Of DNA Glycosylase By APEX1 Pathway antibodies  Displacement Of DNA Glycosylase By APEX1 Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
Diseases associated with anti-TDG antibodyOrgans/Tissues associated with anti-TDG antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >11 publications with TDG and Adenocarcinoma
 Lung Diseases Antibodies  >8 publications with TDG and Lung Diseases
 Neoplasms, Experimental Antibodies  >7 publications with TDG and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >7 publications with TDG and Disease Models, Animal
 Lung Neoplasms Antibodies  >7 publications with TDG and Lung Neoplasms
 Hyperplasia Antibodies  >4 publications with TDG and Hyperplasia
 Adenoma Antibodies  >4 publications with TDG and Adenoma
 Prenatal Exposure Delayed Effects Antibodies  >4 publications with TDG and Prenatal Exposure Delayed Effects
 Liver Neoplasms Antibodies  >3 publications with TDG and Liver Neoplasms
 Inflammation Antibodies  >3 publications with TDG and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >42 publications with TDG and Blood
 Liver Antibodies  >16 publications with TDG and Liver
 Lung Antibodies  >14 publications with TDG and Lung
 Brain Antibodies  >14 publications with TDG and Brain
 Thyroid Antibodies  >12 publications with TDG and Thyroid
 Kidney Antibodies  >11 publications with TDG and Kidney
 Bone Antibodies  >10 publications with TDG and Bone
 Skin Antibodies  >10 publications with TDG and Skin
 Vascular Antibodies  >9 publications with TDG and Vascular
 Heart Antibodies  >9 publications with TDG and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions