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anti-G6PC antibody :: Rabbit anti-Human G6PC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000964
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G6PC, Polyclonal Antibody

★Popular Item★
 Also Known As   

G6PC Antibody

 Product Synonym Names    Glucose-6-phosphatase; G-6-Pase; G6Pase; Glucose-6-phosphatase alpha; G6Pase-alpha; G6PC; G6PT
 Product Gene Name   

anti-G6PC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    232200
 3D Structure    ModBase 3D Structure for P35575
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%,Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Glucose-6-phosphatase protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27196 / sc-27198 / sc-25840
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-G6PC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-G6PC antibody

   Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
 Applications Tested/Suitable for anti-G6PC antibody   

ELISA (EIA), Immunohistochemistry (IHC)

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 Immunohistochemistry (IHC) of anti-G6PC antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7000964 at dilution of 1:100
anti-G6PC antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for G6PC. It may not necessarily be applicable to this product.
 NCBI GI #    393537031
 NCBI GeneID    2538
 NCBI Accession #    NP_000142.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000151.3 [Other Products]
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 UniProt Primary Accession #    P35575 [Other Products]
 UniProt Secondary Accession #    A1L4C0; B4E1C3; K7EL82 [Other Products]
 UniProt Related Accession #    P35575 [Other Products]
 Molecular Weight    20,209 Da
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 NCBI Official Full Name    glucose-6-phosphatase isoform 1
 NCBI Official Synonym Full Names    glucose-6-phosphatase, catalytic subunit
 NCBI Official Symbol    G6PC [Similar Products]
 NCBI Official Synonym Symbols   
G6PT; GSD1; G6PC1; GSD1a
[Similar Products]
 NCBI Protein Information    glucose-6-phosphatase
 UniProt Protein Name    Glucose-6-phosphatase
 UniProt Synonym Protein Names   
Glucose-6-phosphatase alpha; G6Pase-alpha
 Protein Family    Glucose-6-phosphatase
 UniProt Gene Name    G6PC [Similar Products]
 UniProt Synonym Gene Names    G6PT; G-6-Pase; G6Pase; G6Pase-alpha [Similar Products]
 UniProt Entry Name    G6PC_HUMAN
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 NCBI Summary for G6PC    Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]
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 UniProt Comments for G6PC    G6PC: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A). A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Belongs to the glucose-6-phosphatase family.

Protein type: Endoplasmic reticulum; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); Membrane protein, multi-pass; Transporter, SLC family; Transporter; Carbohydrate Metabolism - galactose; EC 3.1.3.9; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to membrane

Molecular Function: glucose-6-phosphatase activity; phosphate binding; phosphotransferase activity, alcohol group as acceptor

Biological Process: carbohydrate metabolic process; cholesterol homeostasis; gluconeogenesis; glucose 6-phosphate metabolic process; glucose homeostasis; glucose transport; glucose-6-phosphate transport; glycogen catabolic process; glycogen metabolic process; hexose transport; multicellular organism growth; phosphorylated carbohydrate dephosphorylation; regulation of gene expression; response to food; steroid metabolic process; transmembrane transport; triacylglycerol metabolic process; urate metabolic process

Disease: Glycogen Storage Disease Ia
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 Research Articles on G6PC    1. By direct DNA sequencing, three novel G6PC variations were identified which expanded the G6PC mutation spectrum, and provided conclusive genetic evidences for the definitive diagnosis of the Chinese patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-G6PC antibodyPathways associated with anti-G6PC antibody
 Reference Product  PubMed Publications
 FOXO1 antibody  >14 publications with G6PC and FOXO1
 CREB1 antibody  >1 publications with G6PC and CREB1
 PGM1 antibody  >1 publications with G6PC and PGM1
 HNF1A antibody  >1 publications with G6PC and HNF1A
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 FoxO Family Signaling Pathway antibodies  FoxO Family Signaling Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
Diseases associated with anti-G6PC antibodyOrgans/Tissues associated with anti-G6PC antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >39 publications with G6PC and Insulin Resistance
 Hepatorenal form of glycogen storage disease Antibodies  >35 publications with G6PC and Hepatorenal form of glycogen storage disease
 Glycogen Storage Disease Type I Antibodies  >35 publications with G6PC and Glycogen Storage Disease Type I
 Liver Diseases Antibodies  >31 publications with G6PC and Liver Diseases
 Fatty Liver Antibodies  >27 publications with G6PC and Fatty Liver
 Hyperglycemia Antibodies  >21 publications with G6PC and Hyperglycemia
 Disease Models, Animal Antibodies  >20 publications with G6PC and Disease Models, Animal
 Hepatomegaly Antibodies  >13 publications with G6PC and Hepatomegaly
 Liver Neoplasms Antibodies  >10 publications with G6PC and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >10 publications with G6PC and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >113 publications with G6PC and Liver
 Kidney Antibodies  >21 publications with G6PC and Kidney
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