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anti-G6PD antibody :: Goat G6PD Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420736
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

G6PD, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-G6PD (aa 308 - 320) Antibody

 Product Synonym Names    Goat Anti-G6PD (aa 305 - 318) Antibody; G6PD; glucose-6-phosphate dehydrogenase; G6PD1; glucose-6-phosphate 1-dehydrogenase; glucose-6-phosphate dehydrogenase; G6PD; G6PD antibody; glucose-6-phosphate dehydrogenase antibody; G6PD1 antibody; glucose-6-phosphate 1-dehydrogenase antibody; glucose-6-phosphate dehydrogenase antibody; G6PD antibody; G6PD (aa 308 - 320)
 Product Gene Name   

anti-G6PD antibody

[Similar Products]
 Antibody/Peptide Pairs    G6PD peptide (MBS425310) is used for blocking the activity of G6PD antibody (MBS420736)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    STNSDDVRDE KVK
 OMIM    300908
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-STNSDDVRDEKVK, from the internal region of the protein sequence according to NP_000393.4 ; NP_001035810.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise both reported isoforms (NP_000393.4 and NP_001035810.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-G6PD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-G6PD antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-G6PD antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Testis shows strong cytoplasm staining in spermatogonia. Recommended concentration, 2-4ug/ml.
Western Blot: Approx 55-60kDa double band observed in Human Testis, Thyroid and Tonsil lysates (calculated MW of 62.5kDa according to NP_000393.4 and 59.3kDa accordiong to NP_001035810.1). Recommended concentration: 0. 03-0.1ug/ml.
Enzyme immunoassay: Sandwich-type ELISA with increasing amount of recombinant G6PD captured by a rabbit antibody. Recommended reporter concentration: 5-10ug/ml.
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 Western Blot (WB) of anti-G6PD antibody    (0. 03ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-G6PD antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-G6PD antibody    (2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-G6PD antibody Immunohistochemistry (IHC) (IHC) image
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 Testing Data of anti-G6PD antibody    (5ug/ml) as the reporter with as the capture rabbit antibody (5ug/ml).
anti-G6PD antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for G6PD. It may not necessarily be applicable to this product.
 NCBI GI #    109389365
 NCBI GeneID    2539
 NCBI Accession #    NP_000393.4 [Other Products]
 NCBI Related Accession #    NP_001035810.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000402.4 [Other Products]
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 UniProt Secondary Accession #    Q16000; Q16765; Q8IU70; Q8IU88; Q8IUA6; Q96PQ2; D3DWX9 [Other Products]
 UniProt Related Accession #    P11413 [Other Products]
 Molecular Weight    62,468 Da
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 NCBI Official Full Name    glucose-6-phosphate 1-dehydrogenase isoform a
 NCBI Official Synonym Full Names    glucose-6-phosphate dehydrogenase
 NCBI Official Symbol    G6PD [Similar Products]
 NCBI Official Synonym Symbols   
G6PD1
[Similar Products]
 NCBI Protein Information    glucose-6-phosphate 1-dehydrogenase
 UniProt Protein Name    Glucose-6-phosphate 1-dehydrogenase
 UniProt Gene Name    G6PD [Similar Products]
 UniProt Synonym Gene Names    G6PD [Similar Products]
 UniProt Entry Name    G6PD_HUMAN
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 NCBI Summary for G6PD    This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for G6PD    G6PD: glucose-6-phosphate dehydrogenase. A cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two splice variant isoforms have been described. The long isoform is found in lymphoblasts, granulocytes and sperm.

Protein type: Other Amino Acids Metabolism - glutathione; Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.49; Oxidoreductase; Cell development/differentiation

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: centrosome; cytoplasm; cytosol; internal side of plasma membrane; intracellular membrane-bound organelle; membrane; microtubule organizing center; nucleus

Molecular Function: glucose binding; glucose-6-phosphate dehydrogenase activity; identical protein binding; NADP binding; protein binding; protein homodimerization activity

Biological Process: cholesterol biosynthetic process; erythrocyte maturation; glucose 6-phosphate metabolic process; glucose metabolic process; glutathione metabolic process; lipid metabolic process; NADP metabolic process; NADPH regeneration; pentose biosynthetic process; pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; regulation of neuron apoptosis; response to ethanol; response to food; response to organic cyclic substance; ribose phosphate biosynthetic process; substantia nigra development

Disease: Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency; Favism, Susceptibility To; Malaria, Susceptibility To
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 Research Articles on G6PD    1. G6PD glycosylation is increased in human lung cancers. Glycosylation activates G6PD activity and increases glucose flux through the PPP, thereby providing precursors for nucleotide and lipid biosynthesis, and reducing equivalents for antioxidant defense.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-G6PD antibodyPathways associated with anti-G6PD antibody
 Reference Product  PubMed Publications
 PGD antibody  >60 publications with G6PD and PGD
 GPI antibody  >59 publications with G6PD and GPI
 PGM1 antibody  >23 publications with G6PD and PGM1
 LDHB antibody  >15 publications with G6PD and LDHB
 H6PD antibody  >4 publications with G6PD and H6PD
 HK1 antibody  >3 publications with G6PD and HK1
 UBC antibody  >2 publications with G6PD and UBC
 TALDO1 antibody  >1 publications with G6PD and TALDO1
 PGLS antibody  >1 publications with G6PD and PGLS
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with anti-G6PD antibodyOrgans/Tissues associated with anti-G6PD antibody
 Disease Name  Pubmed Publications
 Glucosephosphate Dehydrogenase Deficiency Antibodies  >5197 publications with G6PD and Glucosephosphate Dehydrogenase Deficiency
 Anemia Antibodies  >4975 publications with G6PD and Anemia
 Anemia, Hemolytic Antibodies  >4867 publications with G6PD and Anemia, Hemolytic
 Hemolysis Antibodies  >1003 publications with G6PD and Hemolysis
 Poisoning Antibodies  >685 publications with G6PD and Poisoning
 Favism Antibodies  >615 publications with G6PD and Favism
 Nervous System Diseases Antibodies  >406 publications with G6PD and Nervous System Diseases
 Liver Diseases Antibodies  >254 publications with G6PD and Liver Diseases
 Anemia, Hemolytic, Congenital Nonspherocytic Antibodies  >218 publications with G6PD and Anemia, Hemolytic, Congenital Nonspherocytic
 Chromosome Aberrations Antibodies  >167 publications with G6PD and Chromosome Aberrations
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3767 publications with G6PD and Blood
 Liver Antibodies  >584 publications with G6PD and Liver
 Kidney Antibodies  >215 publications with G6PD and Kidney
 Muscle Antibodies  >150 publications with G6PD and Muscle
 Bone Antibodies  >144 publications with G6PD and Bone
 Brain Antibodies  >140 publications with G6PD and Brain
 Skin Antibodies  >118 publications with G6PD and Skin
 Bone Marrow Antibodies  >101 publications with G6PD and Bone Marrow
 Lung Antibodies  >91 publications with G6PD and Lung
 Vascular Antibodies  >82 publications with G6PD and Vascular
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