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anti-GA45G antibody :: Rabbit anti-Human GA45G Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9408260
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GA45G, Polyclonal Antibody

★Popular Item★
 Also Known As   

GA45G Antibody

 Product Synonym Names    Growth arrest and DNA-damage-inducible protein GADD45 gamma; Cytokine-responsive protein CR6; DNA-damage-inducible transcript 2; DDIT-2; GADD45G
 Product Gene Name   

anti-GA45G antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604949
 3D Structure    ModBase 3D Structure for O95257
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous levels of total GA45G protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthesized peptide derived from internal of human GA45G.
 Target Name    GA45G
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-GA45G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GA45G antibody

   Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.Takekawa M., Cell 95:521-530(1998).Fan W., Oncogene 18:6573-6582(1999).Gong R., Cytogenet. Cell Genet. 88:95-96(2000).
 Product Categories/Family for anti-GA45G antibody    Total protein Ab
 Applications Tested/Suitable for anti-GA45G antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-GA45G antibody    Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
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 Western Blot (WB) of anti-GA45G antibody    Western blot analysis of extracts from HepG2 cells and K562 cells, using GA45G antiobdy.
anti-GA45G antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GA45G antibody    Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using GA45G antibody.
anti-GA45G antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-GA45G antibody    Immunofluorescence analysis of A549 cells, using GA45G antibody.
anti-GA45G antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GA45G. It may not necessarily be applicable to this product.
 NCBI GI #    5729836
 NCBI GeneID    10912
 NCBI Accession #    NP_006696.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006705.3 [Other Products]
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 UniProt Primary Accession #    O95257 [Other Products]
 UniProt Secondary Accession #    Q5VZ87; Q9C076 [Other Products]
 UniProt Related Accession #    O95257 [Other Products]
 Molecular Weight    17,121 Da
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 NCBI Official Full Name    growth arrest and DNA damage-inducible protein GADD45 gamma
 NCBI Official Synonym Full Names    growth arrest and DNA-damage-inducible, gamma
 NCBI Official Symbol    GADD45G [Similar Products]
 NCBI Official Synonym Symbols   
CR6; DDIT2; GRP17; GADD45gamma
[Similar Products]
 NCBI Protein Information    growth arrest and DNA damage-inducible protein GADD45 gamma
 UniProt Protein Name    Growth arrest and DNA damage-inducible protein GADD45 gamma
 UniProt Synonym Protein Names   
Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2
 UniProt Gene Name    GADD45G [Similar Products]
 UniProt Synonym Gene Names    CR6; DDIT2; DDIT-2 [Similar Products]
 UniProt Entry Name    GA45G_HUMAN
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 NCBI Summary for GA45G    This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GA45G    GADD45G: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.

Protein type: Nuclear receptor co-regulator; DNA repair, damage; Apoptosis

Chromosomal Location of Human Ortholog: 9q22.1-q22.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: activation of MAPKK activity; regulation of cell cycle; positive regulation of apoptosis; apoptosis; multicellular organismal development; activation of MAPKKK activity; response to stress; negative regulation of protein kinase activity; positive regulation of JNK cascade; cell differentiation
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 Research Articles on GA45G    1. demonstrate for the first time that miR-383 can specifically regulates the expression of Gadd45g by directly targeting to the 3-UTR region of Gadd45g mRNA, a regulatory process conserved in human tumor cells and mouse embryonic stem cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GA45G antibodyPathways associated with anti-GA45G antibody
 Reference Product  PubMed Publications
 GADD45B antibody  >35 publications with GA45G and GADD45B
 GADD45A antibody  >33 publications with GA45G and GADD45A
 PCNA antibody  >9 publications with GA45G and PCNA
 CDK1 antibody  >4 publications with GA45G and CDK1
 CCNB1 antibody  >3 publications with GA45G and CCNB1
 MAP3K4 antibody  >3 publications with GA45G and MAP3K4
 TYK2 antibody  >1 publications with GA45G and TYK2
 JAK2 antibody  >1 publications with GA45G and JAK2
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 P38 MAPK Signaling Pathway antibodies  P38 MAPK Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
Diseases associated with anti-GA45G antibodyOrgans/Tissues associated with anti-GA45G antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >10 publications with GA45G and Nervous System Diseases
 Liver Diseases Antibodies  >9 publications with GA45G and Liver Diseases
 Disease Models, Animal Antibodies  >9 publications with GA45G and Disease Models, Animal
 Brain Diseases Antibodies  >8 publications with GA45G and Brain Diseases
 Adenocarcinoma Antibodies  >7 publications with GA45G and Adenocarcinoma
 Liver Neoplasms Antibodies  >6 publications with GA45G and Liver Neoplasms
 Inflammation Antibodies  >6 publications with GA45G and Inflammation
 Neoplasms, Experimental Antibodies  >6 publications with GA45G and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >6 publications with GA45G and Carcinoma, Hepatocellular
 Necrosis Antibodies  >5 publications with GA45G and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with GA45G and Liver
 Lung Antibodies  >10 publications with GA45G and Lung
 Brain Antibodies  >10 publications with GA45G and Brain
 Prostate Antibodies  >6 publications with GA45G and Prostate
 Testis Antibodies  >5 publications with GA45G and Testis
 Heart Antibodies  >4 publications with GA45G and Heart
 Ovary Antibodies  >3 publications with GA45G and Ovary
 Bone Antibodies  >3 publications with GA45G and Bone
 Kidney Antibodies  >2 publications with GA45G and Kidney
 Muscle Antibodies  >2 publications with GA45G and Muscle
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