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anti-GAB2 antibody :: Goat GAB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420041
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GAB2, Polyclonal Antibody

 Also Known As   

Goat anti-GAB2 Antibody

 Product Synonym Names    GAB2; GRB2-associated binding protein 2; KIAA0571; Grb2-associated binder 2; GAB2 antibody; GRB2-associated binding protein 2 antibody; KIAA0571 antibody; Grb2-associated binder 2 antibody
 Product Gene Name   

anti-GAB2 antibody

[Similar Products]
 Antibody/Peptide Pairs    GAB2 peptide (MBS425540) is used for blocking the activity of GAB2 antibody (MBS420041)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QVDKEKTQAL QN
 OMIM    606203
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QVDKEKTQALQN, from the internal region (near the C Terminus) of the protein sequence according to NP_536739.1; NP_036428.1.
 Epitope    Internal region (near the C Terminus)
 Note    This antibody is expected to recognize both reported isoforms (NP_536739.1; NP_036428.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GAB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GAB2 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GAB2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Approx 80kDa band observed in lysates of cell line K562 (calculated MW of 74.5kDa according to NP_536739.1). Recommended concentration: 0.5-1.5ug/ml.
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 Western Blot (WB) of anti-GAB2 antibody    (0.5ug/ml) staining of K562 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GAB2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GAB2. It may not necessarily be applicable to this product.
 NCBI GI #    18105042
 NCBI GeneID    9846
 NCBI Accession #    NP_536739.1 [Other Products]
 NCBI Related Accession #    NP_036428.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_080491.2 [Other Products]
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 UniProt Secondary Accession #    O60317; A2RRM2; A6NEW9; A7MD36 [Other Products]
 UniProt Related Accession #    Q9UQC2 [Other Products]
 Molecular Weight    69,968 Da
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 NCBI Official Full Name    GRB2-associated-binding protein 2 isoform a
 NCBI Official Synonym Full Names    GRB2 associated binding protein 2
 NCBI Official Symbol    GAB2 [Similar Products]
 NCBI Protein Information    GRB2-associated-binding protein 2
 UniProt Protein Name    GRB2-associated-binding protein 2
 UniProt Synonym Protein Names   
GRB2-associated binder 2; Growth factor receptor bound protein 2-associated protein 2; pp100
 Protein Family    GRB2-associated-binding protein
 UniProt Gene Name    GAB2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0571 [Similar Products]
 UniProt Entry Name    GAB2_HUMAN
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 NCBI Summary for GAB2    This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
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 UniProt Comments for GAB2    GAB2: an adaptor protein of the GRB2-associated binding protein family. Plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: cytoplasm; cytosol; plasma membrane

Molecular Function: phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor protein activity

Biological Process: osteoclast differentiation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of mast cell degranulation; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on GAB2    1. GAB2, GSPT1, TFDP2 and ZFPM1 are four new susceptibility loci for testicular germ cell tumor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GAB2 antibodyPathways associated with anti-GAB2 antibody
 Reference Product  PubMed Publications
 GRB2 antibody  >145 publications with GAB2 and GRB2
 PTPN11 antibody  >45 publications with GAB2 and PTPN11
 SYK antibody  >41 publications with GAB2 and SYK
 LYN antibody  >38 publications with GAB2 and LYN
 BCR antibody  >34 publications with GAB2 and BCR
 MAPK1 antibody  >10 publications with GAB2 and MAPK1
 SHC1 antibody  >10 publications with GAB2 and SHC1
 CRKL antibody  >8 publications with GAB2 and CRKL
 GRAP2 antibody  >2 publications with GAB2 and GRAP2
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Of Signal Transduction Pathway antibodies  Diseases Of Signal Transduction Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 FGFR1 Mutant Receptor Activation Pathway antibodies  FGFR1 Mutant Receptor Activation Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
Diseases associated with anti-GAB2 antibodyOrgans/Tissues associated with anti-GAB2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >34 publications with GAB2 and Nervous System Diseases
 Brain Diseases Antibodies  >34 publications with GAB2 and Brain Diseases
 Breast Neoplasms Antibodies  >20 publications with GAB2 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >19 publications with GAB2 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >16 publications with GAB2 and Inflammation
 Necrosis Antibodies  >11 publications with GAB2 and Necrosis
 Neoplasm Metastasis Antibodies  >11 publications with GAB2 and Neoplasm Metastasis
 Neoplasm Invasiveness Antibodies  >8 publications with GAB2 and Neoplasm Invasiveness
 Melanoma Antibodies  >5 publications with GAB2 and Melanoma
 Disease Models, Animal Antibodies  >4 publications with GAB2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >67 publications with GAB2 and Blood
 Bone Antibodies  >57 publications with GAB2 and Bone
 Brain Antibodies  >23 publications with GAB2 and Brain
 Spleen Antibodies  >13 publications with GAB2 and Spleen
 Lung Antibodies  >11 publications with GAB2 and Lung
 Skin Antibodies  >7 publications with GAB2 and Skin
 Lymph Node Antibodies  >5 publications with GAB2 and Lymph Node
 Muscle Antibodies  >4 publications with GAB2 and Muscle
 Intestine Antibodies  >4 publications with GAB2 and Intestine
 Eye Antibodies  >4 publications with GAB2 and Eye
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