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| Product Name
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GABA A RECEPTOR GAMMA 2 (Gabrg2), Polyclonal Antibody
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| Also Known As
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RABBIT ANTI RAT GABA A RECEPTOR GAMMA 2
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| 3D Structure
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ModBase 3D Structure for P18508
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Chicken (Expected from Sequence), Human (Expected from Sequence), Monkey (Expected from Sequence), Mouse (Expected from Sequence), Zebrafish (Expected from Sequence)
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| Specificity
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This item is specific for the gamma 2 subunit of rat gamma-aminobutyric acid A (GABAA) receptor.
GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell.
GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression.
GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).
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| Form/Format
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Serum
Serum - liquid
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| Perservative Stabilisers
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0.09% Sodium Azide
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| Immunogen
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Synthetic peptide corresponding to a region within rat GABAA receptor gamma 2 subunit.
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| Antiserum Preparation
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Antisera to GABAA receptor were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
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| Target Species
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Rat
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| Preparation and Storage
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Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of despatch.
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| Other Notes
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Small volumes of anti-Gabrg2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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MBS222479 is specific for the gamma 2 subunit of rat gamma-aminobutyric acid A (GABAA) receptor. GABAA receptors are GABA gated chloride channels, which are important mediators of neuronal inhibition in the mammalian central nervous system. Activation of the GABAA site results in increased intracellular chloride concentration and hyperpolarization of the cell. GABAA receptors are pentameric structures assembled from a family of distinct subunits. At least fourteen distinct subunits have been identified, which show distinct patterns of temporal and spatial expression. GABAA receptors may be modulated by several drug types including benzodiazepines and barbiturates, and by phosphorylation by protein kinase C (PKC) and protein kinase A (PKA).
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| Applications Tested/Suitable for anti-Gabrg2 antibody
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Western Blot (WB)
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| Application Notes for anti-Gabrg2 antibody
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Western Blot: This item detects a band of approximately 44 to 47 kDa in rat hippocampus cell lysates.
Western Blotting: Maximum Dilution: 1/1000
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TOP
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| NCBI/Uniprot data below describe general gene information for Gabrg2. It may not necessarily be applicable to this product. |
| NCBI GI #
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34328527
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| NCBI GeneID
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29709
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| NCBI Accession #
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NP_899156.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_183327.1
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[Other Products]
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| UniProt Primary Accession #
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P18508
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[Other Products]
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| UniProt Related Accession #
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P18508
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[Other Products]
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| Molecular Weight
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54,077 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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gamma-aminobutyric acid receptor subunit gamma-2
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| NCBI Official Synonym Full Names
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gamma-aminobutyric acid (GABA) A receptor, gamma 2
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| NCBI Official Symbol
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Gabrg2
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[Similar Products]
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| NCBI Protein Information
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gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2; gamma-aminobutyric acid A receptor, gamma 2
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| UniProt Protein Name
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Gamma-aminobutyric acid receptor subunit gamma-2
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| UniProt Synonym Protein Names
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GABA(A) receptor subunit gamma-2
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| Protein Family
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Gamma-aminobutyric acid receptor
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| UniProt Gene Name
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Gabrg2
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[Similar Products]
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| UniProt Entry Name
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GBRG2_RAT
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| NCBI Summary for Gabrg2
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subunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD, Feb 2006]
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| UniProt Comments for Gabrg2
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GABRG2 iso2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2). ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions. Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8). A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients. Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI); also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Transporter, ion channel; Transporter
Cellular Component: postsynaptic membrane; axon; integral to plasma membrane; cytoplasm; cell junction
Molecular Function: protein binding; chloride channel activity; GABA-A receptor activity; GABA receptor activity; inhibitory extracellular ligand-gated ion channel activity
Biological Process: synaptic transmission; adult behavior; synaptic transmission, GABAergic; chloride transport; signal transduction; gamma-aminobutyric acid signaling pathway; post-embryonic development
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| Research Articles on Gabrg2
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1. RNF34 regulates postsynaptic gamma2-GABAAR clustering and GABAergic synaptic innervation by interacting with and ubiquitinating the gamma2-GABAAR subunit promoting GABAAR degradation
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Pathways associated with anti-Gabrg2 antibody | Diseases associated with anti-Gabrg2 antibody |
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| Organs/Tissues associated with anti-Gabrg2 antibody |
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Antibody 
