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anti-GABRG2 antibody :: Rabbit GABA Receptor A, gamma 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS630080 anti-GABRG2 antibody
Unit / Price
0.1 mL  /  $720 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABA Receptor A, gamma 2 (GABRG2), Polyclonal Antibody

 Also Known As   

GABA Receptor A, gamma 2 (GAG2)

 Product Synonym Names    Anti -GABA Receptor A, gamma 2 (GAG2)
 Product Gene Name   

anti-GABRG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (161494648..161582545). Location: 5q34
 OMIM    137164
 3D Structure    ModBase 3D Structure for P18507
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Bovine, Human, Mouse, Rat
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 Specificity    Recognizes GABA receptor A, Gama 2. The 30 AA rat control peptide is 100% conserved in bovine, human and mouse GAG2 (2). It is ~80% conserved in chicken GAB2. Significant homology is also seen with rat GAG1 (64%), ratGAG3 (55%). It is not clear if anti-GAG21 actually reacts with other gamma subunits. No significant homology is observed with other GAA subunits (alpha, beta etc.). Antibody crossreactivity of anti-GAG21 in various species has also not been studied.
 Purity/Purification    Serum
 Form/Format    Supplied as a liquid, neat serum, 0.05% sodium azide, 40% glycerol.
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 Immunogen    A 30 AA peptide sequence near the N-terminus of rat GAG2 subunit (2). The peptide was coupled to KLH. Location of epitope is extrcellular.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-GABRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GABRG2 antibody

   GABA (g-amino butyric acid) is the most abundant neurotransmitter in mammalian brain. GABA exerts its effects through ionotropic ligand-gated GABAA, GABAC and GABAB receptors (GABABRs). A family of GABA-A receptors subtypes exists, which are generated by alternative splicing of alpha 1-6, beta 1-4, gamma 1-4, delta, epsilon, pie, theta, and rho1-3 to form a heteromeric (pentameric) protein complexes. Various GABA-A subunits show distinct patterns of temporal and spatial expression that may imply its tissue specific physiological role (1). GABA A (GAA) receptor proteins (450-627 aa) are characterized by the presence of a cleavable signal peptide, a large extracellular N-terminus, 3 TM (transmembrane) domains, a large cytoplasmic domain followed by TM4 and C-terminal extracellular domain. The regions between TM3-4 and the large cytoplasmic loop are least conserved among various GAA subunits, which may confer subunit specific functionality. GAA genes are distributed as clusters throughout the human genome (chromosomes 4, 5, 15, and X; delta subunit on chromosome 1). GAA in the brain are the targets of many clinically important drugs.
 Product Categories/Family for anti-GABRG2 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-GABRG2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-GABRG2 antibody    Suitable for use in ELISA, Western Blotting.
Dilution: Western Blotting: 1:1000-1:5000 for neat serum and 1-10ug/ml for affinity pure antibody using ECL.

Control peptide can be used to coat ELISA plates at 1ug/ml and detected with antibodies (1:10-50K for neat serum and 0.5-1ug/ml for affinity pure).
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NCBI/Uniprot data below describe general gene information for GABRG2. It may not necessarily be applicable to this product.
 NCBI GI #    38788135
 NCBI GeneID    2566
 NCBI Accession #    NP_000807.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000816.3 [Other Products]
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 UniProt Primary Accession #    P18507 [Other Products]
 UniProt Secondary Accession #    Q6GRL6; Q6PCC3; Q9UDB3; Q9UN15 [Other Products]
 UniProt Related Accession #    P18507 [Other Products]
 Molecular Weight    54,162 Da [Similar Products]
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit gamma-2 isoform 2
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, gamma 2
 NCBI Official Symbol    GABRG2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit gamma-2; OTTHUMP00000160873; OTTHUMP00000160874; OTTHUMP00000224398; OTTHUMP00000224400; GABA(A) receptor subunit gamma-2
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit gamma-2
 UniProt Synonym Protein Names   
GABA(A) receptor subunit gamma-2
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    GABRG2 [Similar Products]
 UniProt Entry Name    GBRG2_HUMAN
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 NCBI Summary for GABRG2    This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
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 UniProt Comments for GABRG2    GABRG2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2). ECA2 is a subtype of idiopathic generalized epilepsy (IGE) characterized by an onset at age 6-7 years, frequent absence seizures (several per day) and bilateral, synchronous, symmetric 3-Hz spike waves on EEG. During adolescence, tonic-clonic and myoclonic seizures develop. Some individuals manifest ECA2 occurring in combination with febrile convulsions. Defects in GABRG2 are the cause of familial febrile convulsions type 8 (FEB8). A febrile convulsion is defined as a seizure event in infancy or childhood, usually occurring between 6 months and 6 years of age, associated with fever but without any evidence of intracranial infection or defined pathologic or traumatic cause. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients. Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI); also called Dravet syndrome. SMEI is a rare disorder characterized by generalized tonic, clonic, and tonic-clonic seizures that are initially induced by fever and begin during the first year of life. Later, patients also manifest other seizure types, including absence, myoclonic, and simple and complex partial seizures. Psychomotor development delay is observed around the second year of life. SMEI is considered to be the most severe phenotype within the spectrum of generalized epilepsies with febrile seizures-plus. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, chloride; Transporter; Channel, ligand-gated; Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: postsynaptic membrane; axon; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: protein binding; chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; adult behavior; synaptic transmission, GABAergic; transmembrane transport; gamma-aminobutyric acid signaling pathway; post-embryonic development

Disease: Epilepsy, Childhood Absence, Susceptibility To, 2; Generalized Epilepsy With Febrile Seizures Plus, Type 3
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 Research Articles on GABRG2    1. Internalization of GABA(A) receptor gamma2 is not associated with the cellular mechanism underlying febrile seizure genesis in patients with a missense mutation at this receptor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GABRG2 antibodyPathways associated with anti-GABRG2 antibody
 Reference Product  PubMed Publications
 GABARAP antibody  >3 publications with GABRG2 and GABARAP
 DRD5 antibody  >1 publications with GABRG2 and DRD5
 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram
 Synaptic Transmission Pathway antibodies  Synaptic Transmission Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
Diseases associated with anti-GABRG2 antibodyOrgans/Tissues associated with anti-GABRG2 antibody
 Disease Name  Pubmed Publications
 Epilepsy Antibodies  >86 publications with GABRG2 and Epilepsy
 Seizures Antibodies  >63 publications with GABRG2 and Seizures
 Epilepsy, Absence Antibodies  >22 publications with GABRG2 and Epilepsy, Absence
 DRAVET SYNDROME Antibodies  >21 publications with GABRG2 and DRAVET SYNDROME
 Epilepsies, Partial Antibodies  >8 publications with GABRG2 and Epilepsies, Partial
 Alcoholism Antibodies  >6 publications with GABRG2 and Alcoholism
 Anxiety Disorders Antibodies  >5 publications with GABRG2 and Anxiety Disorders
 Substance Withdrawal Syndrome Antibodies  >4 publications with GABRG2 and Substance Withdrawal Syndrome
 Ataxia Antibodies  >3 publications with GABRG2 and Ataxia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >63 publications with GABRG2 and Brain
 Nerve Antibodies  >34 publications with GABRG2 and Nerve
 Kidney Antibodies  >13 publications with GABRG2 and Kidney
 Muscle Antibodies  >1 publications with GABRG2 and Muscle
 Eye Antibodies  >1 publications with GABRG2 and Eye
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