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anti-GABRA4 antibody :: Rabbit anti-Rat GABAA Receptor a 4, Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502045
Testing Data
Unit / Price
0.1 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABAA Receptor a 4, (GABRA4), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-GABAA Receptor, alpha4-Subunit

 Product Gene Name   

anti-GABRA4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_005113.3 (38966016..39040606). Location: 14p11
 3D Structure    ModBase 3D Structure for P28471
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Specific for the ~64k alpha4-subunit of the GABAA receptor in Western blots.
 Purity/Purification    Affinity Purified (Prepared from rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.)
 Form/Format    100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
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 Antigen    Fusion protein from the cytoplasmic loop of the alpha4-subunit of rat GABAA receptor.
 Immunogen Information    Fusion protein from the cytoplasmic loop of the alpha 4 subunit
 Immunogen Species    Rat
 Species Reactivity Note    The antibody has been directly tested for reactivity in Western blots with rat tissue.
 Biological Significance    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003).
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 Preparation and Storage    For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.
 Other Notes    Small volumes of anti-GABRA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GABRA4 antibody

   Affinity purified rabbit polyclonal antibody
 Applications Tested/Suitable for anti-GABRA4 antibody   

Western Blot (WB)

 Application Notes for anti-GABRA4 antibody    Quality Control: Western blots performed on each lot.
WB: 1:1000
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 Testing Data of anti-GABRA4 antibody    anti-GABRA4 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GABRA4. It may not necessarily be applicable to this product.
 NCBI GI #    94400793
 NCBI GeneID    140675
 NCBI Accession #    NP_542154.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_080587.3 [Other Products]
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 UniProt Primary Accession #    P28471 [Other Products]
 UniProt Related Accession #    P28471 [Other Products]
 Molecular Weight    64
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit alpha-4
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, alpha 4
 NCBI Official Symbol    Gabra4 [Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit alpha-4; GABA-A receptor alpha-4 subunit; GABA(A) receptor subunit alpha-4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit alpha-4
 UniProt Synonym Protein Names   
GABA(A) receptor subunit alpha-4
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    Gabra4 [Similar Products]
 UniProt Entry Name    GBRA4_RAT
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 NCBI Summary for GABRA4    alpha 4 subunit of the GABA-A receptor which binds gamma-aminobutyric acid; involved in mood and anxiety [RGD, Feb 2006]
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 UniProt Comments for GABRA4    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily. [View classification]
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Product References and Citations for anti-GABRA4 antibody

   • Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003) A kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor beta-subunits. Mol Cell Neurosci 22:87-97.
• McKernan RM, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1-subtype. Nature Neurosci 3:587-592.
• Mehta AK, Ticku MK (1998) Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: Lack of modulation by chronic ethanol administration. Mol Brain Res 67:194-199.
• Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor gamma2-subunit. Biochem Pharmacol 68:1621-1629.
• Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJS, Thompson SA, Wafford KA (1999) Molecular and functional diversity of the expanding GABAA receptor gene family. Ann NY Acad Sci 868:645-653.
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 Research Articles on GABRA4    1. Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABAA receptor alpha4 subunit at the plasma membrane of hippocampal CA1 spines
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GABRA4 antibodyPathways associated with anti-GABRA4 antibody
 Reference Product  PubMed Publications
 Gabrb1 antibody  >12 publications with GABRA4 and Gabrb1
 Gabrg2 antibody  >7 publications with GABRA4 and Gabrg2
 Gabrb3 antibody  >6 publications with GABRA4 and Gabrb3
 Gabre antibody  >2 publications with GABRA4 and Gabre
 Gabrd antibody  >2 publications with GABRA4 and Gabrd
 Gabrr1 antibody  >2 publications with GABRA4 and Gabrr1
 Gabrr3 antibody  >2 publications with GABRA4 and Gabrr3
 Egr3 antibody  >2 publications with GABRA4 and Egr3
 Gabrr2 antibody  >1 publications with GABRA4 and Gabrr2
 Products by Pathway  Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
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 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
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Diseases associated with anti-GABRA4 antibodyOrgans/Tissues associated with anti-GABRA4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >11 publications with GABRA4 and Nervous System Diseases
 Epilepsy Antibodies  >10 publications with GABRA4 and Epilepsy
 Seizures Antibodies  >8 publications with GABRA4 and Seizures
 Brain Diseases Antibodies  >7 publications with GABRA4 and Brain Diseases
 Status Epilepticus Antibodies  >5 publications with GABRA4 and Status Epilepticus
 Autistic Disorder Antibodies  >4 publications with GABRA4 and Autistic Disorder
 Movement Disorders Antibodies  >3 publications with GABRA4 and Movement Disorders
 Amnesia Antibodies  >2 publications with GABRA4 and Amnesia
 Substance Withdrawal Syndrome Antibodies  >2 publications with GABRA4 and Substance Withdrawal Syndrome
 Tremor Antibodies  >2 publications with GABRA4 and Tremor
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >48 publications with GABRA4 and Brain
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