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anti-GABRG2 antibody :: Rabbit anti-Rat GABAA Receptor, g 2 (Ser327) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502056
Testing Data
Unit / Price
0.1 mL  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABAA Receptor, g 2 (Ser327) (GABRG2), Polyclonal Antibody

 Also Known As   

Anti-Phospho-Ser327 GABAA Receptor, gamma2 subunit

 Product Gene Name   

anti-GABRG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_005109.3 (26934991..27024440, complement). Location: 10q21
 3D Structure    ModBase 3D Structure for P18508
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Specific for ~45k GABAA receptor gamma y2 subunit phosphorylated at Ser327 in Western Blots of rat brain homogenate.
 Purity/Purification    Affinity Purified (Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephospho-peptide affinity columns.)
 Form/Format    100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
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 Antigen    Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser327 of the GABAA receptor, gamma2 subunit.
 Immunogen Information    Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 conjugated to KLH
 Immunogen Species    Rat
 Species Reactivity Note    The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, mouse, human and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
 Biological Significance    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. It has recently been suggested that PKCepsilon regulates the sensitivity of GABAA alpha1beta2gamma2 receptors to ethanol and benzodiazepines through phosphorylation of serine 327 in the large intracellular loop of gamma2 (Qi et al., 2007)
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 Preparation and Storage    For long term storage ~80 degree C is recommended, but shorter term storage at ~20 degree C is also acceptable as aliquots maybe taken without freeze/thawing due to the presence of 50% glycerol. Stock solutions are stable for a minimum of 1 year at -20 degree C.
 Other Notes    Small volumes of anti-GABRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-GABRG2 antibody

   Affinity purified rabbit polyclonal antibody
 Applications Tested/Suitable for anti-GABRG2 antibody   

Dot Blots (DB), Western Blot (WB)

 Application Notes for anti-GABRG2 antibody    Quality Control:
DB: 1:1000
WB: 1:1000

Quality Control Tests: Western Blots performed on each lot.
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 Testing Data of anti-GABRG2 antibody    anti-GABRG2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GABRG2. It may not necessarily be applicable to this product.
 NCBI GI #    34328527
 NCBI GeneID    29709
 NCBI Accession #    NP_899156.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_183327.1 [Other Products]
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 UniProt Primary Accession #    P18508 [Other Products]
 UniProt Related Accession #    P18508 [Other Products]
 Molecular Weight    45
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit gamma-2
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, gamma 2
 NCBI Official Symbol    Gabrg2 [Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit gamma-2
 UniProt Synonym Protein Names   
GABA(A) receptor subunit gamma-2
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    Gabrg2 [Similar Products]
 UniProt Entry Name    GBRG2_RAT
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 NCBI Summary for GABRG2    subunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD, Feb 2006]
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 UniProt Comments for GABRG2    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Post-translational modification: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability

By similarity.

Miscellaneous: This subunit carries the benzodiazepine binding site.

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. [View classification]
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Product References and Citations for anti-GABRG2 antibody

   • Olsen RW, Tobin AJ (1990) Molecular biology of GABAA receptors. FASEB 4:1469-1480.
• Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJS, Thompson SA, Wafford KA (1999) Molecular and functional diversity of the expanding GABAA receptor gene family. Ann NY Acad Sci 868:645-653
• Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor gamma2-subunit. Biochem Pharmacol 68:1621-1629.
• Qi ZH, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Chou WH, Zhang C, Shokat KM, Messing RO (2007) Protein kinase Cepsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem 282(45):33052-63.
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 Research Articles on GABRG2    1. Data indicate there was an inverse correlation between depressive-like behaviors and GABA(A)R alpha1 subunit mRNA expression in the right hemisphere in female and progesterone decreased the GABA(A)R gamma2 mRNA expression only in the left hemisphere of male.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GABRG2 antibodyDiseases associated with anti-GABRG2 antibody
 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Epilepsy Antibodies  >109 publications with GABRG2 and Epilepsy
 Nervous System Diseases Antibodies  >104 publications with GABRG2 and Nervous System Diseases
 Brain Diseases Antibodies  >101 publications with GABRG2 and Brain Diseases
 Seizures Antibodies  >79 publications with GABRG2 and Seizures
 Epilepsy, Absence Antibodies  >32 publications with GABRG2 and Epilepsy, Absence
 Epilepsies, Myoclonic Antibodies  >23 publications with GABRG2 and Epilepsies, Myoclonic
 Substance-Related Disorders Antibodies  >13 publications with GABRG2 and Substance-Related Disorders
 Alcoholism Antibodies  >9 publications with GABRG2 and Alcoholism
 Generalized Epilepsy With Febrile Seizures Plus, Type 1 Antibodies  >7 publications with GABRG2 and Generalized Epilepsy With Febrile Seizures Plus, Type 1
 Anxiety Disorders Antibodies  >6 publications with GABRG2 and Anxiety Disorders
Organs/Tissues associated with anti-GABRG2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >88 publications with GABRG2 and Brain
 Eye Antibodies  >1 publications with GABRG2 and Eye
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