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anti-GABRG2 antibody :: Rabbit anti-Rat GABAA Receptor g2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS502054
Testing Data
Unit / Price
0.05 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABAA Receptor g2 (GABRG2), Polyclonal Antibody

 Also Known As   

Anti-GABAA Receptor, gamma2-Subunit

 Product Gene Name   

anti-GABRG2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_005109.3 (26934991..27024440, complement). Location: 10q21
 3D Structure    ModBase 3D Structure for P18508
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Specific for the ~46k gamma2-subunit of the GABAA receptor in Western blots of rat brain extracts.
 Purity/Purification    Neat Serum (Unpurified neat serum.)
 Form/Format    50 ul neat serum. Adequate material to conduct 10 mini-Western blots.
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 Antigen    Peptide representing a sequence that is specific for the gamma2-subunit of rat GABAA receptor. The sequence of the immunogen has no homology with any other GABAA R-subunit.
 Immunogen Information    Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit conjugated to KLH
 Immunogen Species    Rat
 Reactivity Assumed Based on 100% Sequence Homology    Chicken, human, mouse, non-human primates and zebra fish
 Species Reactivity Note    The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with bovine, chicken, human, mouse, non-human primate and zebra fish tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
 Biological Significance    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). Lastly, phosphorylation of beta-subunits of the receptor has been shown to modulate GABAA-R function (Brandon et al., 2003).
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 Preparation and Storage    For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.
 Other Notes    Small volumes of anti-GABRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GABRG2 antibody

   Rabbit polyclonal antibody
 Applications Tested/Suitable for anti-GABRG2 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GABRG2 antibody    Quality Control: Western blots performed on each lot.
WB: 1:1000
IHC: 1:400
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 Testing Data of anti-GABRG2 antibody    anti-GABRG2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GABRG2. It may not necessarily be applicable to this product.
 NCBI GI #    34328527
 NCBI GeneID    29709
 NCBI Accession #    NP_899156.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_183327.1 [Other Products]
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 UniProt Primary Accession #    P18508 [Other Products]
 UniProt Related Accession #    P18508 [Other Products]
 Molecular Weight    46
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit gamma-2
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) A receptor, gamma 2
 NCBI Official Symbol    Gabrg2 [Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid A receptor, gamma 2; gamma-aminobutyric acid (GABA-A) receptor, subunit gamma 2
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit gamma-2
 UniProt Synonym Protein Names   
GABA(A) receptor subunit gamma-2
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    Gabrg2 [Similar Products]
 UniProt Entry Name    GBRG2_RAT
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 NCBI Summary for GABRG2    subunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD, Feb 2006]
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 UniProt Comments for GABRG2    Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Subunit structure: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Subcellular location: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Post-translational modification: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability

By similarity.

Miscellaneous: This subunit carries the benzodiazepine binding site.

Sequence similarities: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily. [View classification]
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Product References and Citations for anti-GABRG2 antibody

   • Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003) A kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor beta-subunits. Mol Cell Neurosci 22:87-97
• McKernan RM, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor alpha1-subtype. Nature Neurosci 3:587-592.
• Mehta AK, Ticku MK (1998) Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: Lack of modulation by chronic ethanol administration. Mol Brain Res 67:194-199.
• Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor gamma2-subunit. Biochem Pharmacol 68:1621-1629.
• Olsen RW, Tobin AJ (1990) Molecular biology of GABAA receptors. FASEB 4:1469-1480.
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 Research Articles on GABRG2    1. Data indicate there was an inverse correlation between depressive-like behaviors and GABA(A)R alpha1 subunit mRNA expression in the right hemisphere in female and progesterone decreased the GABA(A)R gamma2 mRNA expression only in the left hemisphere of male.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GABRG2 antibodyDiseases associated with anti-GABRG2 antibody
 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Epilepsy Antibodies  >109 publications with GABRG2 and Epilepsy
 Nervous System Diseases Antibodies  >104 publications with GABRG2 and Nervous System Diseases
 Brain Diseases Antibodies  >101 publications with GABRG2 and Brain Diseases
 Seizures Antibodies  >79 publications with GABRG2 and Seizures
 Epilepsy, Absence Antibodies  >32 publications with GABRG2 and Epilepsy, Absence
 Epilepsies, Myoclonic Antibodies  >23 publications with GABRG2 and Epilepsies, Myoclonic
 Substance-Related Disorders Antibodies  >13 publications with GABRG2 and Substance-Related Disorders
 Alcoholism Antibodies  >9 publications with GABRG2 and Alcoholism
 Generalized Epilepsy With Febrile Seizures Plus, Type 1 Antibodies  >7 publications with GABRG2 and Generalized Epilepsy With Febrile Seizures Plus, Type 1
 Anxiety Disorders Antibodies  >6 publications with GABRG2 and Anxiety Disorders
Organs/Tissues associated with anti-GABRG2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >88 publications with GABRG2 and Brain
 Eye Antibodies  >1 publications with GABRG2 and Eye
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