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anti-GABBR1 antibody :: Rabbit GABBR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2523048
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABBR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

GABBR1 Polyclonal Antibody

 Product Synonym Names    GB1; GPRC3A; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2
 Product Gene Name   

anti-GABBR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603540
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1.6mg/mL (lot specific)
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 Immunogen    Synthetic peptide of human GABBR1
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GABBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GABBR1 antibody

   Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21. 3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants.
 Product Categories/Family for anti-GABBR1 antibody    Neuroscience
 Applications Tested/Suitable for anti-GABBR1 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-GABBR1 antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-GABBR1 antibody    Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using GABBR1 Polyclonal Antibody at dilution 1:30
anti-GABBR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GABBR1. It may not necessarily be applicable to this product.
 NCBI GI #    167000400
 NCBI GeneID    2550
 NCBI Accession #    NP_068704.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_021904.2 [Other Products]
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 UniProt Secondary Accession #    O95375; O95468; O95975; O96022; Q5STL4; Q5SUJ8; Q5SUL3; Q71SG6; Q86W60; Q9UQQ0; B0UXY7 [Other Products]
 UniProt Related Accession #    Q9UBS5 [Other Products]
 Molecular Weight    65,082 Da
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 NCBI Official Full Name    gamma-aminobutyric acid type B receptor subunit 1 isoform c
 NCBI Official Synonym Full Names    gamma-aminobutyric acid (GABA) B receptor, 1
 NCBI Official Symbol    GABBR1 [Similar Products]
 NCBI Official Synonym Symbols   
GB1; GPRC3A; GABABR1; GABBR1-3; dJ271M21.1.1; dJ271M21.1.2
[Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid type B receptor subunit 1; GABA-BR1; GABAB, subunit 1c; seven transmembrane helix receptor
 UniProt Protein Name    Gamma-aminobutyric acid type B receptor subunit 1
 Protein Family    Gamma-aminobutyric acid type B receptor
 UniProt Gene Name    GABBR1 [Similar Products]
 UniProt Synonym Gene Names    GPRC3A; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1 [Similar Products]
 UniProt Entry Name    GABR1_HUMAN
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 NCBI Summary for GABBR1    Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jun 2009]
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 UniProt Comments for GABBR1    GABBR1: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; GPCR, family 3; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: presynaptic membrane; postsynaptic membrane; integral to plasma membrane; cytoplasm; dendrite; extracellular region; plasma membrane; cell junction

Molecular Function: protein binding; GABA-B receptor activity

Biological Process: synaptic transmission; negative regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase inhibiting pathway; gamma-aminobutyric acid signaling pathway
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 Research Articles on GABBR1    1. Chronic alcohol altered exon/intron expression and splice junction levels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GABBR1 antibodyPathways associated with anti-GABBR1 antibody
 Reference Product  PubMed Publications
 GABBR2 antibody  >9 publications with GABBR1 and GABBR2
 GAD2 antibody  >3 publications with GABBR1 and GAD2
 UBD antibody  >1 publications with GABBR1 and UBD
 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
Diseases associated with anti-GABBR1 antibodyOrgans/Tissues associated with anti-GABBR1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with GABBR1 and Nervous System Diseases
 Brain Diseases Antibodies  >11 publications with GABBR1 and Brain Diseases
 Seizures Antibodies  >6 publications with GABBR1 and Seizures
 Alcoholism Antibodies  >3 publications with GABBR1 and Alcoholism
 Memory Disorders Antibodies  >2 publications with GABBR1 and Memory Disorders
 Movement Disorders Antibodies  >2 publications with GABBR1 and Movement Disorders
 Autistic Disorder Antibodies  >2 publications with GABBR1 and Autistic Disorder
 Fibrosis Antibodies  >1 publications with GABBR1 and Fibrosis
 Disease Models, Animal Antibodies  >1 publications with GABBR1 and Disease Models, Animal
 Weight Loss Antibodies  >1 publications with GABBR1 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with GABBR1 and Brain
 Blood Antibodies  >6 publications with GABBR1 and Blood
 Liver Antibodies  >1 publications with GABBR1 and Liver
 Adrenal Gland Antibodies  >1 publications with GABBR1 and Adrenal Gland
 Nerve Antibodies  >1 publications with GABBR1 and Nerve
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