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anti-GABRB2 antibody :: Goat GABRB2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421790 anti-GABRB2 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABRB2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-GABRB2 Antibody

 Product Synonym Names    GABRB2; gamma-aminobutyric acid (GABA) A receptor, beta 2; MGC119386; MGC119388; MGC119389; OTTHUMP00000160872; GABRB2 antibody; gamma-aminobutyric acid (GABA) A receptor; beta 2 antibody; MGC119386 antibody; MGC119388 antibody; MGC119389 antibody; OTTHUMP00000160872 antibody
 Product Gene Name   

anti-GABRB2 antibody

[Similar Products]
 Antibody/Peptide Pairs    GABRB2 peptide (MBS426270) is used for blocking the activity of GABRB2 antibody (MBS421790)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    HSFGRNALER HVAQ
 OMIM    600232
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-HSFGRNALERHVAQ, from the internal region of the protein sequence according to NP_068711.1; NP_000804.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both reported isoforms (NP_068711.1; NP_000804.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GABRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GABRB2 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-GABRB2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments gave an approx 80kDa band in Mouse Brain lysates after 0.2 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 59.2kDa according to Human NP_068711.1 and 54.6kDa according to Mouse NP_032096.1. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for GABRB2. It may not necessarily be applicable to this product.
 NCBI GI #    12548785
 NCBI GeneID    2561
 NCBI Accession #    NP_068711.1 [Other Products]
 NCBI Related Accession #    NP_000804.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021911.2 [Other Products]
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 UniProt Secondary Accession #    Q16323; Q4FZB2; A8K115; A8K1A0; D1LYT0; D1LYT1 [Other Products]
 UniProt Related Accession #    P47870 [Other Products]
 Molecular Weight    42,741 Da
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit beta-2 isoform 1
 NCBI Official Synonym Full Names    gamma-aminobutyric acid type A receptor beta2 subunit
 NCBI Official Symbol    GABRB2 [Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit beta-2
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit beta-2
 UniProt Synonym Protein Names   
GABA(A) receptor subunit beta-2
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    GABRB2 [Similar Products]
 UniProt Entry Name    GBRB2_HUMAN
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 NCBI Summary for GABRB2    The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GABRB2    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
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 Research Articles on GABRB2    1. Deletion of the N-terminal extension and putative alpha-helix in heteromeric alpha1beta2gamma2 GABAA receptors in the beta2 subunit affected GABA sensitivity and desensitization.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GABRB2 antibodyPathways associated with anti-GABRB2 antibody
 Reference Product  PubMed Publications
 GABRA1 antibody  >65 publications with GABRB2 and GABRA1
 GABRG2 antibody  >52 publications with GABRB2 and GABRG2
 GABRA6 antibody  >18 publications with GABRB2 and GABRA6
 GABRB1 antibody  >12 publications with GABRB2 and GABRB1
 GABRA2 antibody  >11 publications with GABRB2 and GABRA2
 GABRA4 antibody  >11 publications with GABRB2 and GABRA4
 GABRA5 antibody  >10 publications with GABRB2 and GABRA5
 GABRG3 antibody  >5 publications with GABRB2 and GABRG3
 GABRA3 antibody  >3 publications with GABRB2 and GABRA3
 Products by Pathway  Pathway Diagram
 GABA A Receptor Activation Pathway antibodies  GABA A Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
Diseases associated with anti-GABRB2 antibodyOrgans/Tissues associated with anti-GABRB2 antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >30 publications with GABRB2 and Schizophrenia
 Nervous System Diseases Antibodies  >19 publications with GABRB2 and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >18 publications with GABRB2 and Central Nervous System Diseases
 Brain Diseases Antibodies  >16 publications with GABRB2 and Brain Diseases
 Epilepsy Antibodies  >14 publications with GABRB2 and Epilepsy
 Seizures Antibodies  >13 publications with GABRB2 and Seizures
 Substance-Related Disorders Antibodies  >8 publications with GABRB2 and Substance-Related Disorders
 Disease Models, Animal Antibodies  >5 publications with GABRB2 and Disease Models, Animal
 Ataxia Antibodies  >2 publications with GABRB2 and Ataxia
 Movement Disorders Antibodies  >2 publications with GABRB2 and Movement Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >64 publications with GABRB2 and Brain
 Kidney Antibodies  >13 publications with GABRB2 and Kidney
 Eye Antibodies  >4 publications with GABRB2 and Eye
 Muscle Antibodies  >3 publications with GABRB2 and Muscle
 Intestine Antibodies  >2 publications with GABRB2 and Intestine
 Thyroid Antibodies  >1 publications with GABRB2 and Thyroid
 Blood Antibodies  >1 publications with GABRB2 and Blood
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