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anti-GABRR1 antibody :: Rabbit anti-Human, Mouse GABRR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7043674
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GABRR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

GABRR1 Antibody

 Product Synonym Names    Gamma-aminobutyric acid receptor subunit rho-1; GABA(A) receptor subunit rho-1; GABA(C) receptor; GABRR1
 Product Gene Name   

anti-GABRR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137161
 3D Structure    ModBase 3D Structure for P24046
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen Affinity Purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Gamma-aminobutyric acid receptor subunit rho-1 protein (365-465AA)
 Conjugate    Non-conjugated
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22960 / sc-21336 / sc-31452 / sc-16879 / sc-21338 / sc-25707
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GABRR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GABRR1 antibody

   GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
 Applications Tested/Suitable for anti-GABRR1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-GABRR1 antibody    Western blot
All lanes: GABRR1 antibody at 1.25ug/ml+mouse eye tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 56,54,46 kDa
Observed band size: 56 kDa

anti-GABRR1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GABRR1 antibody    Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7043674 at dilution 1:100
anti-GABRR1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-GABRR1 antibody    Immunohistochemistry of paraffin-embedded human thymus using MBS7043674 at dilution 1:100
anti-GABRR1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GABRR1. It may not necessarily be applicable to this product.
 NCBI GI #    375493570
 NCBI GeneID    2569
 NCBI Accession #    NP_001243632.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256703.1 [Other Products]
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 UniProt Primary Accession #    P24046 [Other Products]
 UniProt Secondary Accession #    Q9BX06; A1L401; B4DJK8; B4DQT5; B7ZBQ7 [Other Products]
 UniProt Related Accession #    P24046 [Other Products]
 Molecular Weight    45,516 Da
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 NCBI Official Full Name    gamma-aminobutyric acid receptor subunit rho-1 isoform b
 NCBI Official Synonym Full Names    gamma-aminobutyric acid type A receptor rho1 subunit
 NCBI Official Symbol    GABRR1 [Similar Products]
 NCBI Protein Information    gamma-aminobutyric acid receptor subunit rho-1
 UniProt Protein Name    Gamma-aminobutyric acid receptor subunit rho-1
 UniProt Synonym Protein Names   
GABA(A) receptor subunit rho-1; GABA(C) receptor
 Protein Family    Gamma-aminobutyric acid receptor
 UniProt Gene Name    GABRR1 [Similar Products]
 UniProt Entry Name    GBRR1_HUMAN
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 NCBI Summary for GABRR1    GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for GABRR1    GABRR1: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass; Channel, ligand-gated; Transporter, ion channel; Channel, chloride

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: gamma-aminobutyric acid signaling pathway; synaptic transmission; transport
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 Research Articles on GABRR1    1. Both GABAAalpha1 and GABAArho1 mRNAs and proteins were identified in cultured retinal pigment epithelial cells; antibody staining was mainly localized to the cell membrane and was also present in the cytoplasm but not in the nucleus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GABRR1 antibodyDiseases associated with anti-GABRR1 antibody
 Products by Pathway  Pathway Diagram
 GABA A (rho) Receptor Activation Pathway antibodies  GABA A (rho) Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 GABAergic Synapse Pathway antibodies  GABAergic Synapse Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Morphine Addiction Pathway antibodies  Morphine Addiction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with GABRR1 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with GABRR1 and Brain Diseases
Organs/Tissues associated with anti-GABRR1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with GABRR1 and Brain
 Eye Antibodies  >8 publications with GABRR1 and Eye
 Connective Tissue Antibodies  >1 publications with GABRR1 and Connective Tissue
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