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anti-GAD67 antibody :: Rabbit GAD67 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9408409
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GAD67, Polyclonal Antibody

 Also Known As   

GAD67 Antibody

 Product Synonym Names    4.1.1.15; GLUTAMATE DECARBOXYLASE; BRAIN; 67-KD; glutamate decarboxylase 1 (brain
 Product Gene Name   

anti-GAD67 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603513
 3D Structure    ModBase 3D Structure for Q99259
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous levels of total GAD67 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthesized peptide derived from human GAD67.
 Target Name    GAD67
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-GAD67 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GAD67 antibody

   Catalyzes the production of GABA.Jamil Kanaani, J. Biol. Chem., Dec 1999; 274: 37200.Susan M. Murphy, J. Histochem. Cytochem., Nov 1998; 46: 1261.M. Gierdalski, Cereb Cortex, Sep 2001; 11: 806 - 815.Kyung Soo Kim, Diabetes, Sep 2002; 51: 2764.
 Product Categories/Family for anti-GAD67 antibody    Total protein Ab
 Applications Tested/Suitable for anti-GAD67 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GAD67 antibody    Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
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 Immunohistochemistry (IHC) of anti-GAD67 antibody    Immunohistochemical analysis of paraffin-embedded human brain tissue using GAD67 antibody.
anti-GAD67 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-GAD67 antibody    Western blot analysis of extracts from LOVO cells, using GAD67 antibody.
anti-GAD67 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-GAD67 antibody    Western blot analysis of extracts from A549 cells (Lane 2) and HepG2 cells (Lane 3), using GAD67 antiobdy. The lane on the left is treated with systhesized peptide.
anti-GAD67 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GAD67. It may not necessarily be applicable to this product.
 NCBI GI #    58331246
 NCBI GeneID    2571
 NCBI Accession #    NP_000808.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000817.2 [Other Products]
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 UniProt Primary Accession #    Q99259 [Other Products]
 UniProt Secondary Accession #    Q49AK1; Q53TQ7; Q9BU91; Q9UHH4 [Other Products]
 UniProt Related Accession #    Q99259 [Other Products]
 Molecular Weight    47,440 Da
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 NCBI Official Full Name    glutamate decarboxylase 1 isoform GAD67
 NCBI Official Synonym Full Names    glutamate decarboxylase 1 (brain, 67kDa)
 NCBI Official Symbol    GAD1 [Similar Products]
 NCBI Official Synonym Symbols   
GAD; SCP; CPSQ1
[Similar Products]
 NCBI Protein Information    glutamate decarboxylase 1
 UniProt Protein Name    Glutamate decarboxylase 1
 UniProt Synonym Protein Names   
67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
 UniProt Gene Name    GAD1 [Similar Products]
 UniProt Synonym Gene Names    GAD; GAD67; GAD-67 [Similar Products]
 UniProt Entry Name    DCE1_HUMAN
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 NCBI Summary for GAD67    This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GAD67    GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Carbohydrate Metabolism - butanoate; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine; EC 4.1.1.15; Lyase; Amino Acid Metabolism - alanine, aspartate and glutamate

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: intracellular; plasma membrane; presynaptic active zone; vesicle membrane

Molecular Function: glutamate binding; glutamate decarboxylase activity; protein binding; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding

Biological Process: gamma-aminobutyric acid biosynthetic process; glutamate catabolic process; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; response to drug; synaptic transmission

Disease: Cerebral Palsy, Spastic Quadriplegic, 1
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 Research Articles on GAD67    1. These results suggest a link between altered inhibitory mechanisms and synchrony and, therefore point to potential mechanisms via which a disruption in neurodevelopmental processes might lead to pathophysiology associated with schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GAD67 antibodyPathways associated with anti-GAD67 antibody
 Reference Product  PubMed Publications
 RELN antibody  >9 publications with GAD67 and RELN
 SLC32A1 antibody  >2 publications with GAD67 and SLC32A1
 GLUL antibody  >2 publications with GAD67 and GLUL
 GLS antibody  >1 publications with GAD67 and GLS
 ABAT antibody  >1 publications with GAD67 and ABAT
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Diseases associated with anti-GAD67 antibodyOrgans/Tissues associated with anti-GAD67 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >63 publications with GAD67 and Mental Disorders
 Schizophrenia Antibodies  >44 publications with GAD67 and Schizophrenia
 Nervous System Diseases Antibodies  >30 publications with GAD67 and Nervous System Diseases
 Brain Diseases Antibodies  >24 publications with GAD67 and Brain Diseases
 Disease Models, Animal Antibodies  >18 publications with GAD67 and Disease Models, Animal
 Anxiety Disorders Antibodies  >9 publications with GAD67 and Anxiety Disorders
 Seizures Antibodies  >9 publications with GAD67 and Seizures
 Depressive Disorder Antibodies  >8 publications with GAD67 and Depressive Disorder
 Autistic Disorder Antibodies  >6 publications with GAD67 and Autistic Disorder
 Cognition Disorders Antibodies  >4 publications with GAD67 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >110 publications with GAD67 and Brain
 Embryonic Tissue Antibodies  >2 publications with GAD67 and Embryonic Tissue
 Muscle Antibodies  >2 publications with GAD67 and Muscle
 Eye Antibodies  >2 publications with GAD67 and Eye
 Kidney Antibodies  >2 publications with GAD67 and Kidney
 Bone Antibodies  >1 publications with GAD67 and Bone
 Thymus Antibodies  >1 publications with GAD67 and Thymus
 Uncharacterized Tissue Antibodies  >1 publications with GAD67 and Uncharacterized Tissue
 Intestine Antibodies  >1 publications with GAD67 and Intestine
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