NP_003848.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,700 Da
NCBI Official Full Name
galanin receptor type 2
NCBI Official Synonym Full Names
galanin receptor 2
NCBI Protein Information
galanin receptor type 2
UniProt Protein Name
Galanin receptor type 2
UniProt Synonym Gene Names
UniProt Entry Name
GALR2_HUMAN
NCBI Summary for GALR2
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Comments for GALR2
GALR2: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; peptide hormone binding; galanin receptor activity
Biological Process: multicellular organismal development; negative regulation of adenylate cyclase activity; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; elevation of cytosolic calcium ion concentration; learning and/or memory; cell surface receptor linked signal transduction; muscle contraction; neuropeptide signaling pathway; digestion; positive regulation of transcription from RNA polymerase II promoter; feeding behavior; neurite development
Research Articles on GALR2
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Products associated with anti-GALR2 antibody
Pathways associated with anti-GALR2 antibody
Diseases associated with anti-GALR2 antibody
Organs/Tissues associated with anti-GALR2 antibody
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